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学术急诊医学档案

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  4. Case Report

卷 10 编号 1 (2022)

一月 2022

Cocaine and Volatile Nitrite–Induced Methemoglobinemia; a Case Report and Treatment Approach Review

  • Milena Ribeiro Paixão
  • Tarso Augusto Duenhas Accorsi
  • Luis Felipe Lopes Prada
  • Lucas Zoboli Pocebon
  • Karine De Amicis Lima
  • Karen Francine Köhler
  • Leandro Santini Echenique
  • José Leão de Souza Júnior

学术急诊医学档案, 卷 10 编号 1 (2022), 1 一月 2022 , 第 e75 页
https://doi.org/10.22037/aaem.v10i1.1753 已出版: 2022-09-21

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摘要

Cyanosis is typically a sign of a potentially life-threatening condition in the emergency department and requires immediate workup and treatment. This case report highlights the diagnostic reasoning and clinical approach to cocaine- and volatile nitrite–induced methemoglobinemia (MHG). MHG is a rare, life-threatening cause of cyanosis. The diagnosis must be suspected in the emergency department in the presence of hypoxia and cyanosis disproportionate to cardiopulmonary repercussions and refractory to oxygen supplementation. Acquired causes are more prevalent than genetics, and recreational drugs should be highly suspected. Despite the rarity of this situation, cyanosis precipitants and the specificities of each hemoglobinopathy are reviewed in this article.

关键词:
  • Methemoglobinemia
  • Cocaine
  • Nitrites
  • Emergency Medicine
  • Case Report
  • pdf (English)

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Ribeiro Paixão M, Accorsi TAD, Prada LFL, Pocebon LZ, De Amicis Lima K, Köhler KF, 等. Cocaine and Volatile Nitrite–Induced Methemoglobinemia; a Case Report and Treatment Approach Review. Arch Acad Emerg Med [网际网络]. 2022年9月21日 [见引于 2026年7月7日];10(1):e75. 载于: https://journals.sbmu.ac.ir/aaem/index.php/AAEM/article/view/1753
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参考

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Sohn CH, Seo DW, Ryoo SM, Lee JH, Kim WY, Lim KS, et al. Life-threatening methemoglobinemia after unintentional ingestion of antifreeze admixtures containing sodium nitrite in the construction sites. Clin Toxicol (Phila). 2014;52(1):44-7.

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UNODC. Cocaine – a spectrum of products. Cocaine Insights 2. Vienna: UNODC; 2021.

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Filliatre L, Broséus J, Pissard S, Mekki C, Feugier P, Perrin J. Amyl nitrite inhalation, a "volatile" anemia. Am J Hematol. 2016;91(4):448.

Sonck E, Bourmanne E, Bruteyn J, Dolip W. Methemoglobinemia due to use of poppers: a case report. J Med Case Rep. 2022;16(1):244.

Le A, Yockey A. Use of "Poppers" among Adults in the United States, 2015-2017. J Psychoactive Drugs. 2020;52(5):433-9.

Sahu KK, Mishra AK, Lal A, George SV. Acetaminophen induced methemoglobinemia. Clin Toxicol (Phila). 2020;58(7):784-5.

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