学术急诊医学档案

卷 10 编号 1 (2022)

Distinguishing Characteristics of COVID-19-Associated Mucormycosis; a Case Series

学术急诊医学档案, 卷 10 编号 1 (2022), 1 一月 2022 , 第 e66 页
https://doi.org/10.22037/aaem.v10i1.1644

摘要

Introduction: Since the emergence of COVID-19 pandemic, several articles have reported the co-existence of mucormycosis and COVID-19. This study aimed to distinguish the characteristics of COVID-19-associated rhinocerebral mucormycosis.

Methods: In this case series, 18 patients with COVID-19-associated rhinocerebral mucormycosis and unique clinical manifestations and outcomes, who were referred to Amiralam Hospital, a tertiary otorhinolaryngology center, Tehran, Iran, during the COVID-19 era, were reported.

Results: Eighteen patients with the mean age of 62.0 ± 11.6 (range: 42 – 83) years were studied (50% males). The mean time interval between diagnosis of COVID-19 and first manifestation of mucormycosis was 15.5 ± 9.7 days. The most common presenting symptom was facial paresthesia (72.2%). Fifty percent of patients developed frozen eye. Palatal necrosis was seen in 7 cases (38.8%). Remarkably, facial paralysis was observed in 5 (27.7%) patients. Another notable clinical picture was cavernous sinus thrombosis, seen in 7 patients. We also had two cases of carotid artery occlusion. Three patients, unfortunately, passed away.

Conclusion: Rhinocerebral mucormycosis is one of the most important complications of COVID-19 patients, especially those with underlying diseases. It seems that the key to proper management of mucormycosis is early diagnosis and timely intervention, which could give a patient a chance to live more.

关键词:
  • COVID-19
  • Mycoses
  • mucormycosis
  • paranasal sinuses

参考

deShazo, R.D., K. Chapin, and R.E. Swain, Fungal sinusitis. N Engl J Med, 1997. 337(4): p. 254-9.

Shafer, W., M. Hine, and B. Levy, Shafer's Textbook of Oral Pathology. 5 [sup] th ed. 2006, Amsterdam: Elsevier Health Sciences.

Singh, J. and N.M. Prasanna, Phycomycosis in an apparently normal host. J Otolaryngol, 1977. 6(1): p. 37-42.

Sachdeva, K., Rhino-oculo Cerebral Mucormycosis with Multiple Cranial Nerve Palsy in Diabetic Patient: Review of Six Cases. Indian J Otolaryngol Head Neck Surg, 2013. 65(4): p. 375-9.

Hosseini, S.M. and P. Borghei, Rhinocerebral mucormycosis: pathways of spread. Eur Arch Otorhinolaryngol, 2005. 262(11): p. 932-8.

Kemper, J., et al., Recovery from rhinocerebral mucormycosis in a ketoacidotic diabetic patient: a case report. J Laryngol Otol, 1993. 107(3): p. 233-5.

Bigner, S., P. Burger, and P. Dubois, Diagnosis of cerebral mucormycosis by needle aspiration biopsy. A case report. Acta cytologica, 1982. 26(5): p. 699-704.

Saldanha, M., R. Reddy, and M.J. Vincent, Title of the Article: Paranasal Mucormycosis in COVID-19 Patient. Indian J Otolaryngol Head Neck Surg, 2021: p. 1-4.

Moorthy, A., et al., SARS-CoV-2, Uncontrolled Diabetes and Corticosteroids-An Unholy Trinity in Invasive Fungal Infections of the Maxillofacial Region? A Retrospective, Multi-centric Analysis. J Maxillofac Oral Surg, 2021. 20(3): p. 418-425.

Bayram, N., et al., Susceptibility of severe COVID-19 patients to rhino-orbital mucormycosis fungal infection in different clinical manifestations. Jpn J Ophthalmol, 2021. 65(4): p. 515-525.

Patel, A., et al., Multicenter Epidemiologic Study of Coronavirus Disease-Associated Mucormycosis, India. Emerg Infect Dis, 2021. 27(9): p. 2349-2359.

Ahmadikia, K., et al., The double-edged sword of systemic corticosteroid therapy in viral pneumonia: A case report and comparative review of influenza-associated mucormycosis versus COVID-19 associated mucormycosis. Mycoses, 2021. 64(8): p. 798-808.

Pakdel, F., et al., Mucormycosis in patients with COVID-19: A cross-sectional descriptive multicentre study from Iran. Mycoses, 2021. 64(10): p. 1238-1252.

Raj, A., N. Kaur, and N. Kaur, Cavernous sinus thrombosis with central retinal artey occlusion in COVID-19: A case report and review of literature. Indian J Ophthalmol, 2021. 69(5): p. 1327-1329.

Khacha, A., et al., Cavernous sinus thrombosis in a COVID-19 patient: A case report. Radiol Case Rep, 2021. 16(3): p. 480-482.

Selvadurai, S. and J.S. Virk, Cavernous sinus thrombosis secondary to sphenoid mycetoma following COVID-19 infection. Qjm, 2021. 114(8): p. 594-595.

Cancer-Perez, S., et al., Symptomatic Common Carotid Free-Floating Thrombus in a COVID-19 Patient, Case Report and Literature Review. Ann Vasc Surg, 2021. 73: p. 122-128.

Álvarez Moreno, Y., et al., Internal carotid artery thrombosis in COVID 19. Colomb Med (Cali), 2020. 51(3): p. e504560.

Pisano, T.J., I. Hakkinen, and I. Rybinnik, Large Vessel Occlusion Secondary to COVID-19 Hypercoagulability in a Young Patient: A Case Report and Literature Review. J Stroke Cerebrovasc Dis, 2020. 29(12): p. 105307.

Little, J.S., et al., Invasive Fungal Carotiditis: A Rare Manifestation of Cranial Invasive Fungal Disease: Case Series and Systematic Review of the Literature. Open Forum Infect Dis, 2019. 6(10): p. ofz392.

Patil, A., et al., Angioinvasive rhinocerebral mucormycosis with complete unilateral thrombosis of internal carotid artery-case report and review of literature. BJR Case Rep, 2016. 2(2): p. 20150448.

Cornely, O.A., et al., Global guideline for the diagnosis and management of mucormycosis: an initiative of the European Confederation of Medical Mycology in cooperation with the Mycoses Study Group Education and Research Consortium. Lancet Infect Dis, 2019. 19(12): p. e405-e421.

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