Propofol + Granisetron vs. Propofol + Metoclopramide in Symptom Management of Acute Migraine Headache; a Double-Blind Randomized Clinical Trial
学术急诊医学档案,
卷 10 编号 1 (2022),
1 一月 2022
,
第 e19 页
https://doi.org/10.22037/aaem.v10i1.1561
摘要
Introduction: Acute headache is one of the most common reasons for emergency department (ED) visits. This study aimed to compare the combination of propofol and granisetron with propofol and metoclopramide in symptom management of acute migraine headache.
Methods: In this double-blind randomized clinical trial, 60 adult patients with acute migraine headache who referred to ED were randomly divided into two groups of propofol + metoclopramide and propofol + granisetron. Pain and nausea/vomiting severity as well as blood pressure were compared between groups 30, 45, and 60 minutes after treatment.
Results: The two groups had similar situation regarding mean age (p = 0.606), sex distribution (p = 0.793), baseline severity of pain (p = 0.642), frequency of nausea/vomiting (p = 0.488), and vital signs (p > 0.05). The severity of pain was similar in the two groups 30 (p = 0.731), 45 (p = 0.460), and 60 (p = 0.712) minutes after treatment. The number of patients with resistant nausea and vomiting 60 minutes after treatment was significantly higher in metoclopramide group (30.0% versus 10.0%; p = 0.033). Diastolic pressure 60 minutes after treatment (81.43 ±8.94 vs. 74.97 ± 4.8; p = 0.001) and heart rate 30 minutes after treatment (68.87 ±6.52 vs. 73.57± 7.62; p = 0.013) had statistically significant differences between the groups.
Conclusion: The combination of propofol and granisetron was superior to propofol and metoclopramide in case of controlling nausea and vomiting of cases with acute migraine headache; meanwhile, no differences were observed in case of pain relief and hemodynamic status between the two groups.
- Propofol
- granisetron
- metoclopramide
- migraine disorders
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参考
Ballantyne J, Fishman S, Abdi S. The massachusetts general hospital handbook of pain management: Lippincott Williams & Wilkins; 2002.
Togha M, Rahmat M, Nilavary K, Ashrafian H, Razeghi S. Efficacy of Cinnarizine and Sodium Valproate in migraine prophylaxis: a clinical trial. Tehran University Medical Journal TUMS Publications. 2006;64(6):121-30.
Levis P, Rowland MD. Merritt,s neurology. 11th ed. NewYork: Lippincolt Williams & Wilkins; 2005.
Holroyd K, Drew J, Cottrell C, Romanek K, Heh V. Impaired functioning and quality of life in severe migraine: the role of catastrophizing and associated symptoms. Cephalalgia. 2007;27(10):1156-65.
Sadovsky R. Using migraine prophylaxis in adult patients. American Family Physician. 2001;63(12):2441.
Calhoun AH, Ford S, Pruitt AP, Fisher KG. The point prevalence of dizziness or vertigo in migraine–and factors that influence presentation. Headache: The Journal of Head and Face Pain. 2011;51(9):1388-92.
Kostic MA, Gutierrez FJ, Rieg TS, Moore TS, Gendron RT. A prospective, randomized trial of intravenous prochlorperazine versus subcutaneous sumatriptan in acute migraine therapy in the emergency department. Annals of emergency medicine. 2010;56(1):1-6.
Callan JE, Kostic MA, Bachrach EA, Rieg TS. Prochlorperazine vs. promethazine for headache treatment in the emergency department: a randomized controlled trial. The Journal of emergency medicine. 2008;35(3):247-53.
Friedman BW, Esses D, Solorzano C, Dua N, Greenwald P, Radulescu R, et al. A randomized controlled trial of prochlorperazine versus metoclopramide for treatment of acute migraine. Annals of emergency medicine. 2008;52(4):399-406.
Friedman B, Corbo J, Lipton R, Bijur P, Esses D, Solorzano C, et al. A trial of metoclopramide vs sumatriptan for the emergency department treatment of migraines. Neurology. 2005;64(3):463-8.
ALBIBI R, McCALLUM RW. Metoclopramide: pharmacology and clinical application. Annals of Internal Medicine. 1983;98(1):86-95.
The internet drug index, kytril (granisetron) drug; 2010. http://www.rxlist.com/reglan-drug/clinical-pharmacology.htm.].
Krusz JC, Scott V, Belanger J. Intravenous propofol: unique effectiveness in treating intractable migraine. Headache: The Journal of Head and Face Pain. 2000;40(3):224-30.
Melchart D, Linde K, Streng A, Reitmayr S, Hoppe A, Brinkhaus B, et al. Acupuncture Randomized Trials (ART) in patients with migraine or tension-type headache--design and protocols. Forschende Komplementarmedizin und klassische Naturheilkunde = Research in complementary and natural classical medicine. 2003;10(4):179-84.
Wen L, Badgett R, Cornell J. Number needed to treat: a descriptor for weighing therapeutic options. American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists. 2005;62(19):2031-6.
Amiri H, Ghodrati N, Nikuyeh M, Shams-Vahdati S, Jalilzadeh-Binazar M. Comparison of granisetron and metoclopramide in the treatment of pain and emesis in migraine patients: A randomized controlled trial study. Turkish Journal of Emergency Medicine. 2017;17(2):61-4.
Sharafkhah M, Alamdar MA, Massoudifar A, Abdolrazaghnejad A, Ebrahimi-Monfared M, Saber R, et al. Comparing the efficacy of ondansetron and granisetron augmentation in treatment-resistant obsessive-compulsive disorder: a randomized double-blind placebo-controlled study. International clinical psychopharmacology. 2019;34(5):222-33.
Aleyasin A, Hayatshahi A, Saffarieh E, Torkamandi H, Aghahosseini M, Hanafi S, et al. No superiority of granisetron over metoclopramide in prevention of post-operative nausea and vomiting: a randomized clinical trial. The Journal of Obstetrics and Gynecology of India. 2014;64(1):59-62.
Bagi B, Bagi T, Bagi D, Tucić-Nemet K, Maljanović M, Kalezić N, et al. Dexasone and metoclopramide vs. granisetron in the prevention of postoperative nausea and vomiting. Srpski arhiv za celokupno lekarstvo. 2019;147(7-8):432-8.
Akerman S, Williamson DJ, Hill RG, Goadsby PJ. The effect of adrenergic compounds on neurogenic dural vasodilatation. European journal of pharmacology. 2001;424(1):53-8.
Riad W, Marouf H. Combination therapy in the prevention of PONV after strabismus surgery in children: granisetron, ondansetron, midazolam with dexamethasone. Middle East J Anesthesiol. 2009;20(3):431-6.
Bhattacharya D, Banerjee A. Comparison of ondansetron and granisetron for prevention of nausea and vomiting following day care gynaecological laparoscopy. Indian journal of Anaesthesia. 2003;47(4):279-82.
Ommid M, Ahmad M, Jehan N, Shiekh F, Nazir S, Nissa G. Comparative evaluation of ondansetron and granisetron in prevention of postoperative nausea and vomiting following laparoscopic cholecystectomy in females. IOSR. 2013; 4: 15-20.
Gauchan S, Thapa C, Shakya P, Bhattarai R, Shakya S. Ondansetron and Granisetron for prevention of postoperative nausea and vomiting following laparoscopic cholecystectomy. Journal of Nepal Medical Association. 2014;52(193):682-6.
Savant K, Khandeparker RVS, Berwal V, Khandeparker PV, Jain H. Comparison of ondansetron and granisetron for antiemetic prophylaxis in maxillofacial surgery patients receiving general anesthesia: a prospective, randomised, and double blind study. Journal of the Korean Association of Oral and Maxillofacial Surgeons. 2016;42(2):84-9.
Abdul Kareem Mohammed Z, Ahmed Jawad S, Salih Mahdi M, Fowzi Ibrahim W. A Comparative Study for the effect of ondansetron and metoclopramide in prevention of postoperative nausea and vomiting. journal of kerbala university. 2017;13(3):20-7.
Malekshoar M, Jarineshin H, Kalani N, Vatankhah M. Comparing the effect of metoclopramide and promethazine on preventing nausea and vomiting after laparoscopic cholecystectomy: A double-blind clinical trial. Koomesh journal. 2021;23(2):203-10.
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