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Vol. 14 No. 1 (2026)

October 2025

What Emergency Medicine Specialists Need to Know about Hantavirus: A Letter to the Editor

  • Mostafa Alavi-Moghaddam

Archives of Academic Emergency Medicine, Vol. 14 No. 1 (2026), 1 October 2025 , Page e28
https://doi.org/10.22037/aaem.v14i1.3073 Published: 2026-07-15

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Abstract

Hantavirus infection is an uncommon but potentially life-threatening zoonotic disease that requires early recognition in the emergency department. This letter summarizes the epidemiology, transmission, clinical manifestations, diagnostic approaches, and current management of hantavirus pulmonary syndrome (HPS) and hemorrhagic fever with renal syndrome (HFRS). Although the initial presentation is often nonspecific, rapid progression to respiratory failure, shock, or acute kidney injury may occur, necessitating prompt diagnosis and aggressive supportive care. Serologic testing remains the primary diagnostic modality, while treatment is largely supportive, with extracorporeal membrane oxygenation reserved for selected patients with severe HPS. Increased awareness among emergency physicians and timely implementation of infection-control measures are essential to improve patient outcomes and reduce mortality.

Keywords:
  • Hantavirus Pulmonary Syndrome
  • , emergency department
  • Hantavirus
  • pdf

How to Cite

1.
Alavi-Moghaddam M. What Emergency Medicine Specialists Need to Know about Hantavirus: A Letter to the Editor. Arch Acad Emerg Med [Internet]. 2026 Jul. 15 [cited 2026 Jul. 27];14(1):e28. Available from: https://journals.sbmu.ac.ir/aaem/index.php/AAEM/article/view/3073
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References

1. World Health Organization. Hantavirus disease outbreak update.[Available at: https://www.who.int/news-room/fact-sheets/detail/hantavirus; 2026.]

2. MacNeil A, Nichol ST, Spiropoulou CF. Hantavirus pulmonary syndrome. Virus Res. 2011;162(1-2):138-147.

3. Centers for Disease Control and Prevention. Hantavirus pulmonary syndrome (HPS).[Available at: https://www.cdc.gov/han/php/notices/han00528.html; 2025.]

4. Vaheri A, Strandin T, Hepojoki J, Sironen T, Henttonen H, Mäkelä S, et al. Uncovering the mysteries of hantavirus infections. Nat Rev Microbiol. 2013;11(8):539-550.

5. Jonsson CB, Figueiredo LT, Vapalahti O. A global perspective on hantavirus ecology, epidemiology, and disease. Clin Microbiol Rev. 2010;23(2):412-441.

6. Heyman P, Vaheri A. Situation of hantavirus infections and haemorrhagic fever with renal syndrome in European countries. Emerg Infect Dis. 2008;14(12):1887-1891.

7. Schmaljohn C, Hjelle B. Hantaviruses: a global disease problem. Emerg Infect Dis. 1997;3(2):95-104.

8. Mertz GJ, Hjelle BL, Bryan RT. Hantavirus infection. Adv Intern Med. 1997;42:369-421.

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