Lactate/Albumin Ratio vs. NEWS-Lactate in Sepsis-Induced Acute Kidney Injury Prognosis; Comment on Le Xuan at al. Study
Archives of Academic Emergency Medicine,
Vol. 13 No. 1 (2025),
6 September 2025
,
Page e72
https://doi.org/10.22037/aaem.v13i1.2878
Abstract
A study by Le Xuan et al. suggested that the lactate/albumin ratio (LAR) may aid in predicting sepsis-associated acute kidney injury. However, overlapping receiver operating characteristic (ROC) curve confidence intervals, creatinine-only acute kidney injury (AKI) definitions, and single-point biomarker assessments limit interpretation. Given its single-centre retrospective design, broader validation with dynamic biomarkers and kidney-specific comparators is needed before the LAR can be integrated into sepsis risk stratification.
- Sepsis
- Acute kidney injury
- Prognosis
- Biomarkers
- Risk assessment
- Validation study
How to Cite
References
Le Xuan D, Nguyen Hai G, Vu Anh D, Do Thanh H. Prognostic Value of Lactate/Albumin Ratio and NEWS-Lactate in Predicting Sepsis-Associated Acute Kidney Injury: A Retrospective Analysis. Arch Acad Emerg Med. 2025;13(1):e61.
Singer M, Deutschman CS, Seymour CW, Shankar-Hari M, Annane D, Bauer M, et al. The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3). JAMA. 2016;315(8):801-10.
Khwaja A. KDIGO clinical practice guidelines for acute kidney injury. Nephron Clin Pract. 2012;120(4):c179-84.
Zarbock A, Nadim MK, Pickkers P, Gomez H, Bell S, Joannidis M, et al. Sepsis-associated acute kidney injury: consensus report of the 28th Acute Disease Quality Initiative workgroup. Nat Rev Nephrol. 2023;19(6):401-17.
Zhang Z, Xu X. Lactate clearance is a useful biomarker for the prediction of all-cause mortality in critically ill patients: a systematic review and meta-analysis*. Crit Care Med. 2014;42(9):2118-25.
Wang H, Kang X, Shi Y, Bai ZH, Lv JH, Sun JL, et al. SOFA score is superior to APACHE-II score in predicting the prognosis of critically ill patients with acute kidney injury undergoing continuous renal replacement therapy. Ren Fail. 2020;42(1):638-45.
Bagshaw SM, George C, Bellomo R, Committee ADM. Early acute kidney injury and sepsis: a multicentre evaluation. Crit Care. 2008;12(2):R47.
Park SW, Yeo NY, Kang S, Ha T, Kim TH, Lee D, et al. Early Prediction of Mortality for Septic Patients Visiting Emergency Room Based on Explainable Machine Learning: A Real-World Multicenter Study. J Korean Med Sci. 2024;39(5):e53.
Hwang TS, Park HW, Park HY, Park YS. Prognostic Value of Severity Score Change for Septic Shock in the Emergency Room. Diagnostics (Basel). 2020;10(10).
Li H, Ren Q, Shi M, Ma L, Fu P. Lactate metabolism and acute kidney injury. Chin Med J (Engl). 2025;138(8):916-24.
- Abstract Viewed: 208 times
- pdf Downloaded: 415 times
Download Statastics
Make a Submission
SJR
COPE
