Peganum Harmala (Aspand) Intoxication; a Case Report
Archives of Academic Emergency Medicine,
Vol. 4 No. 2 (2016),
1 May 2016
,
Page 106-107
https://doi.org/10.22037/aaem.v4i2.230
Abstract
There are several reports in the literature indicating a great variety of pharmacological effects for peganum harmala or aspand such as sedative anti-bacterial, anti-fungal, antiviral and antiprotozoal. Some people believe that can be used for treatment of some organic or psychiatric disorders. We introduce a woman with history of long time constipation that was disappointed in novel medical treatment and decided to use comminuted Aspand to relieve her problem. Two hours after use, the intoxication symptoms manifested as blurred vision, phonophobia, floating feeling, and tinnitus ringing. Here we report the treatment process and outcome of this case.- Peganum
- harmine
- poisoning
- emergency department
How to Cite
References
Bahmani M, Rafieian-Kopaei M, Parsaei P, Mohsenzadegan A. The anti-leech effect of Peganum harmala L. extract and some anti-parasite drugs on Limnatis nilotica. Afr J Microbiol Res. 2012;6(10):2586-90.
Mahmoudian M, Jalipour H, Dardashti PS. Toxicity of Peganum harmala: review and a case report. Iranian Journal of Pharmacology & Therapeutics. 2002;1(1):1-4.
Moloudizargari M, Mikaili P, Aghajanshakeri S, Asghari MH, Shayegh J. Pharmacological and therapeutic effects of Peganum harmala and its main alkaloids. Pharmacognosy reviews. 2013;7(14):199.
Berdai MA, Labib S, Harandou M. Peganum harmala L. Intoxication in a Pregnant Woman. Case reports in emergency medicine. 2014;2014.
Aqel M, Hadidi M. Direct relaxant effect of Peganum harmala seed extract on smooth muscles of rabbit and guinea pig. Pharmaceutical Biology. 1991;29(3):176-82.
Shi C-C, Chen S-Y, Wang G-J, Liao J-F, Chen C-F. Vasorelaxant effect of harman. European journal of pharmacology. 2000;390(3):319-25.
Aarons DH, Victor Rossi G, Orzechowski RF. Cardiovascular actions of three harmala alkaloids: harmine, harmaline, and harmalol. Journal of pharmaceutical sciences. 1977;66(9):1244-8.
Rhalem N, Khattabi A, Soulaymani A, Ouammi L, Soulaymani-Bencheikh R. Etude rétrospective des intoxications par les plantes au Maroc: Expérience du Centre Anti Poison et de Pharmacovigilance du Maroc (1980-2008). Toxicologie Maroc. 2010;5:5-8.
Casey R. 298 alleged anti-fertility plants of India. 1960.
Saha J, Savini E, Kasinathan S. Ecbolic properties of Indian medicinal plants. 1961.
Boulos L. Medicinal Plants of North Africa. Medicinal plants of North Africa. 1983.
Abdel-Fattah A, Matsumoto K, Murakami Y, El-Hady K, Mohamed M, Watanabe H. Inhibitory effects of Harmaline on the tryptophan induced 5-hvdroxyt syndrome and body tempeRature changes in pargyline-pretreated Rats. Jpn J Pharmacol. 1996;27:39-47.
Tahri N. Intoxication par le Harmel" Peganum harmala" N. Tahri, N. Rhalem, R. Soulaymani.
Achour S, Rhalem N, Khattabi A, et al. [Peganum harmala L. poisoning in Morocco: about 200 cases]. Therapie. 2011;67(1):53-8
- Abstract Viewed: 276 times
- PDF Downloaded: 3462 times
- HTML Downloaded: 48 times