Archives of Academic Emergency Medicine

Vol. 11 No. 1 (2023)

Piperonylbutoxide as a Dubious Cause of Cardiac Manifestations in Pyrethroid Insecticide Poisoning; a Letter to Editor

Archives of Academic Emergency Medicine, Vol. 11 No. 1 (2023), 15 November 2022 , Page e10
https://doi.org/10.22037/aaem.v11i1.1848

Abstract

There is little evidence regarding pyrethroid poisoning manifesting with cardiac problems in the literature. Many authors, however, adopted that pyrethroids have a direct effect on heart tissue and can cause cardiotoxicity. Interestingly, no experimental studies have yet determined its mechanism of toxicity on cardiac muscle cells. This letter aims to describe the probable cause of clinical manifestations attributed to piperonylbutoxide, an ignored ingredient in pesticide poisoning, which is added to many pesticide products to increase their insecticidal potency. We think that cardiac manifestations in some cases of pyrethroid poisoning are due to the concomitant piperonylbutoxide toxicity and its possible effect on norepinephrine release from adrenal gland, which might explain changes in cardiac findings. Thus, it is necessary for all clinical toxicologists to determine suspicious ingredients when they are facing a doubtful manifestation.

Keywords:
  • Piperonylbutoxide
  • pyrethroid
  • poisoning
  • cardiotoxicity

How to Cite

1.
Faress F, Ameri M, Vasheghani Farahani M, Marashi SM. Piperonylbutoxide as a Dubious Cause of Cardiac Manifestations in Pyrethroid Insecticide Poisoning; a Letter to Editor. Arch Acad Emerg Med [Internet]. 2023 Jan. 1 [cited 2025 Dec. 7];11(1):e10. Available from: https://journals.sbmu.ac.ir/aaem/index.php/AAEM/article/view/1848

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