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Vol. 10 No. 1 (2022)

January 2022

Clinical Features and Outcomes of Acute Chlorine Gas Inhalation; a Brief Report

  • Taymmia Ejaz
  • Sheema Saadia
  • Safia Akhlaq
  • Adil Aziz
  • Muhammad Arslan Ahmed
  • Aisha Fareed Siddiqui

Archives of Academic Emergency Medicine, Vol. 10 No. 1 (2022), 1 January 2022 , Page e15
https://doi.org/10.22037/aaem.v10i1.1448 Published: 2022-02-14

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Abstract

Methods: This retrospective cross-sectional study, evaluated the clinical features and outcomes (length of hospital stay, complications, and mechanical ventilation requirement) of patients presenting to ED of Aga Khan University Hospital, Karachi, Pakistan, with history of chlorine gas exposure at the Engro Plant from 6th March to 14th March 2020.

Results: 38 patients with mean age of 33.1 ± 8.1 years presented to ED with history of chlorine gas exposure (100% male).  4 (10.5%) cases had comorbid diseases. Most common presenting symptom was dyspnea, observed in 33 (86.8%) cases, followed by cough, seen in 27 (71.1%) subjects. 13.2% (5/38) patients had infiltration on chest x-ray and 33 (86.8 %) required hospitalization. 6 (15.8%) patients had repeat presentation requiring hospitalization or ED visit. 18 (47.4%) were managed with high flow oxygen therapy, 9 (23.7%) required non-invasive ventilation and one patient was intubated due to development of pneumo-mediastinum. Mean length of stay was 1.55 ± 1.58 days and no patients died. Presence of tachycardia was the only finding significantly associated with need for oxygen (p = 0.033) and non-invasive ventilation (p = 0.012).

Conclusion: The majority of patients presenting with acute chlorine gas exposure showed good clinical outcomes and rapid recovery, however, a high index of suspicion and vigilance should be maintained for complications such as pneumomediastinum and acute respiratory distress syndrome in these patients.

Keywords:
  • chlorine gas
  • outcomes
  • poisoning
  • industrial accident
  • inhalation exposure
  • accidents
  • occupational
  • gas poisoning
  • outcome assessment
  • health care
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How to Cite

1.
Ejaz T, Saadia S, Akhlaq S, Aziz A, Ahmed MA, Siddiqui AF. Clinical Features and Outcomes of Acute Chlorine Gas Inhalation; a Brief Report. Arch Acad Emerg Med [Internet]. 2022 Feb. 14 [cited 2026 Jul. 7];10(1):e15. Available from: https://journals.sbmu.ac.ir/aaem/index.php/AAEM/article/view/1448
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References

Carlisle M, Lam A, Svendsen ER, Aggarwal S, Matalon S. Chlorine-induced cardiopulmonary injury. Annals of the New York Academy of Sciences. 2016;1374:159-67.

Govier P, Coulson JM. Civilian exposure to chlorine gas: A systematic review. Toxicol Lett. 2018;293:249-52.

Zellner T, Eyer F. Choking agents and chlorine gas - History, pathophysiology, clinical effects and treatment. Toxicol Lett. 2020;320:73-9.

Huynh Tuong A, Despreaux T, Loeb T, Salomon J, Megarbane B, Descatha A. Emergency management of chlorine gas exposure - a systematic review. Clin Toxicol (Phila). 2019;57(2):77-98.

Balte PP, Clark KA, Mohr LC, Karmaus WJ, Van Sickle D, Svendsen ER. The Immediate Pulmonary Disease Pattern following Exposure to High Concentrations of Chlorine Gas. Pulm Med. 2013;2013:325869.

Hoyle GW, Svendsen ER. Persistent effects of chlorine inhalation on respiratory health. Annals of the New York Academy of Sciences. 2016;1378:33-40.

Ammoura AM, S.Aqqad A, T.Hamdan MA. Chlorine Gas Poisoning. Journal of The Royal Medical Services2004.

Güloğlu C, Kara İH, Erten PG. Acute Accidental Exposure to Chlorine Gas in the Southeast of Turkey: A study of 106 Cases. Environmental Research. 2002;88:89-93.

Khilji MF. Clinical Presentations and Outcomes of Industrial Chlorine Gas Exposure Incidence in Oman. Prehospital and Disaster Medicine. 2021;36:18-24.

Masoumi G, Maniey M, Aghababaeian H, Ostadtaghizadeh A, Araghi Ahvazi L. Lessons Learned From a Chlorine Gas Leakage in Dezful City, Iran. Disaster Medicine and Public Health Preparedness. 2020:1-7.

Sever M, Mordeniz C, Sever F, Dokur M. Accidental Chlorine Gas Intoxication: Evaluation of 39 Patients. Journal of Clinical Medicine Research. 2009.

Van Sickle D, Wenck MA, Belflower A, Drociuk D, Ferdinands J, Holguin F, et al. Acute health effects after exposure to chlorine gas released after a train derailment. Am J Emerg Med. 2009;27(1):1-7.

Bhatti MW. 137 faint in Port Qasim industrial gas leakage. The News. 7th March 2020.

Kim J-A, Yoon S-Y, Cho S-Y, Yu J-H, Kim H-S, Lim G-I, et al. Acute health effects of accidental chlorine gas exposure. Ann Occup Environ Med. 2014;26.

Christensen BE, Duncan MA, King SC, Hunter C, Ruckart P, Orr MF. Challenges During a Chlorine Gas Emergency Response. Disaster Med Public Health Prep. 2016;10(4):553-6.

Clark KA, Karmaus WJ, Mohr LC, Cai B, Balte P, Gibson JJ, et al. Lung Function before and after a Large Chlorine Gas Release in Graniteville, South Carolina. Ann Am Thorac Soc. 2016;13(3):356-63.

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