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The Intravenous Laser Blood Irradiation in Chronic Pain and Fibromyalgia

Sirous Momenzadeh, Mohammadzaki Abbasi, Asghar Ebadifar, Mohammadreza Aryani, Jafar Bayrami, Fatemeh Nematollahi




Intravenous laser blood irradiation was first introduced into therapy by the Soviet scientists EN.Meschalkin and VS.Sergiewski in 1981. Originally this method was developed for the treatment of cardiovascular diseases. Improvement of rheologic properties of the blood as well as improvement of microcirculation and reduction of the area of infarction has been proved. Further, reduction of dysrhythmia and sudden cardiac death was achieved. At first, only the Helium-Neon laser (632.8 nm) was used in this therapy. For that, a power of 1-3mW and a period of exposure of 20-60 minutes were applied. The treatments were carried out once or twice a day up to ten appointments in all1. In the years after, many, and for the most part Russian studies showed  that helium-neon laser had various effects on many organs and on the hematologic and immunologic system. The studies were published mainly in Russian which were little known in the West because of decades of political separation, and were regarded with disapproval. Besides clinical research and application for patients, the cell biological basis was developed by the Estonian cell biologist Tiina Karuat the same time. An abstract is to be found in her work “The Science of Low-Power Laser-Therapy”


laser; pain; irradiation


Bakeeva L, Manteiffel V, Rodichev E, Karu T. Formation of gigantic mitochondria in human blood lymphocytes under the effect of an He-Ne laser. Mol-Biol-Mosk. 1993; 27 (3):608-17

Bodenburg R. Laser needle-acupuncture and intravascular laser blood-irradiation from a legal point of view. Pain Acupunct. 2007; 33,1:42-8.

Boev S, Selivonenko V. The impact of the intravenous He-Ne-Laser therapy on the antioxidant system in patients with stable insertion angina and postinfarkt cardiosclerosis. Klin-Med-Mosk. 1997; 75,12:30-3.

Brill G, Grigoriev S, Romanova T. Changes of leucocyte metabolism in He-Ne laser blood irradiation in vitro. Proc SPIE.

; 1981:204-9.

Dimitriev A, Iudin V, Aparov N, Matyrnov V. Effect of intravascular laser irradiation of the blood on blood cells in pancreatitis. Klin Med (Mosk.). 1989; 67, 5:108-10.

Driianskaia V. The clinico-immunological effects of immunotherapy in patients with acute pyelonephritis. Lik-Sprava. 1997;(4):89-92.

Dube A, Hausal H, Gupta PK. Modulation of macrophage structure and function by low level He-Ne irradiation. Photochem.

Photobiol. Sci. 2003; 2( 8):851-5.

Frick G, Dehmlow R. Practice Guideline UVBund HOT. Fundamentals and use of stimulus-reaction-therapy. Stuttgart: Hippokrates. 2001:77-9.

Funk J, Kruse A, Kirchner H. Cytokine production after helium-neon laser irradiation in cultures of human peripheral blood mononuclear cells. J Photochem. Photobiol. 1992; 16, 3-4: 347-55.

Gasparyan L. Laser Irradiation of the blood. Laser Partner - Clinixperience – First volume 2003:1-4.

Grubnik V, Dotsenko S, Chuev P, Basenke I, Salemekh A. Laser in the prevention of early postoperative complications in the surgical treatment of obesity. Klein-Khir. 1994; 8:25-7.

Gulsoy M, Ozer G, Bozkulak O, Tabakoglu H, Aktas E, Deniz G, et al. LLLT increases lymphocyte proliferation. J

Photochem. Photobiol. 2006; 82, 3:199-202.

Gür A, Karacoc M, Nas K, Cevik R, Sarac A, Ataoglu S. Effects of low power laser and low dose amitryptiline therapy on clinical symptoms and qualità of life in fibromyalgia: a single-blind, placebo-controlled trial. Rheumatol Int. 2002; 22, 5:188-93.

DOI: http://dx.doi.org/10.22037/2010.v6i1.7800