• Logo
  • SBMUJournals

A Low-Cost Method for Optical Tomography

Mohsen Erfanzadeh, Saied Alikhani, Mohammad Ali Ansari, Ezeddin Mohajerani
404

Views

PDF

Abstract

INTRODUCTION: In this study, arrangement of a low-cost optical tomography device compared to other methods such as frequency domain diffuse tomography or time domain diffuse tomography is reported. This low-cost diffuse optical imaging technique is based on the detection of light after propagation in tissue. These detected signals are applied to predict the location of in-homogeneities inside phantoms. The device is assessed for phantoms representing homogenous healthy breast tissues as well as those representing healthy breast tissues with a lesion inside.

METHODS: A diode laser at 780nm and 50 mW is used as the light source. The scattered light is then collected from the outer surface of the phantom by a detector. Both laser and detector are fiber coupled. The detector fiber may turn around the phantom to collect light scattered at different angles. Phantoms made of intralipid as the scattering medium and ink as the absorbing medium are used as samples. Light is collected after propagation in the phantoms and the capability of the device in collecting data and detecting lesions inside the phantoms is assessed. The fact that the detection fiber orbits around the sample and detects light from various angles has eliminated the need to use several detectors and optical fibers. The results obtained from experiments are compared with the results obtained from a finite element method (FEM) solution of diffusion equation in cylindrical geometry written in FORTRAN.

RESULTS: The graphs obtained experimentally and numerically are in good accordance with each other. The device has been able to detect lesions up to 13 mm inside the biological phantom.

CONCLUSION: The data achieved by the optical tomography device is compared with the data achieved via a FEM code written in FORTRAN. The results indicate that the presented device is capable of providing the correct pattern of diffusely backscattered and transmitted light. The data achieved from the device is in excellent correlation with the numerical solution of the diffusion equation. Therefore, results indicate the applicability of the reported device. This device may be used as a base for an optical imaging. It is also capable of detecting lesions inside the phantoms


Keywords

optical tomography; diode laser; biological phantom.

References

The cancer cure foundation [Internet].California:The fondation; C2002-2012, Available from http://www. cancure.org/statistics.htm

Breast cancer: incidence rises while death continues to fall. Available via http://www.statistics.gov.uk. Dec 2006

Tabar L, Yen MF, Vitak B, Chen HH, Smith RA, Duffy SW. Mammography service screening and mortality in breast cancer patients: 20-year follow-up before and after introduction of screening. Lancet 2003; 361(9367):1405- 10.

Huynh PT, Jarolimek AM, Daye S. The false-negative mammogram. Radiographics 1998; 18(5):1137-54.

Elmore JG, Barton MB, Moceri VM, Polk S, Arena PJ, Fletcher SW. Ten-year risk of false positive screening mammograms and clinical breast examinations. N Engl J Med 1998; 338(16):1089-96.

Lucassen A, Watson E, Eccles D. Evidence based case report: Advice about mammography for a young woman with a family history of breast cancer. BMJ 2001; 322(7293):1040-2.

Hylton N. Magnetic resonance imaging of the breast: Opportunities to improve breast cancer management. J Clin Oncol 2005; 23(8):1678-84.

Wang X, Pang Y, Ku G, Xie X, Stoica G Wang LV. Noninvasive laser-induced photoacoustic tomography for structural and functional imaging of the brain in vivo. Nat Biotechnol 2003; 21(7): 803-6.

Su Y, Zhang F, Xu1 K, Yao J, Wang RK. A photoacoustic tomography system for imaging of biological tissues. J Phys D: Appl Phys 2005; 38 (15): 2640-4.

Tokuno H, Hatanaka N, Takada M, Nambu A. B-mode and color Doppler ultrasound imaging for localization of microelectrode in monkey brain. Neurosci Res 2000; 36(4):335-8.

Cutler M. Transillumination of the breast. Surg Gynaecol Obstet 1929; 48:721-7.

V.V Tuchin(ed), Handbook of photonics for biomedical science. CRC Press. Boca Raton. 2010.

Ansari MA, Alikhani S, Mohajerani E, Massudi R, The numerical and experimental study of photon diffusion inside biological tissue using boundary integral method, Opt Commun 2012; 285(5):851-855.

Salomatina E, Jiang B, Novak J, Yaroslavsky AN. Optical properties of normal and cancerous human skin in the visible and near infrared spectral range. J Biomed Opt 2006;11(6): 064026.

Iftimia N, Gu X, Xu Y, Jiang H. A compact paralleldetection optical mammography system. Rev Sci Instrum 2003; 74:2836-42.

Choe R. Diffuse optical tomography and spectroscopy of breast cancer and fetal brain, p. 83. Thesis of doctor of philosophy, Department of Physics and Astronomy University of Pennsylvania, 2005.

Yang J, Zhang T, Yang H, Jiang H, Fast multispectral diffuse optical tomography system for in vivo threedimensional imaging of seizure dynamics, Appl Optics 2012; 51(6): 3461-3469.




DOI: https://doi.org/10.22037/jlms.v3i3.2852