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The Efficacy of IPL in Periorbital Skin Rejuvenation: An Open-Label Study

Behrooz Barikbin, Zahra Akbari, Reza Vafaee, Zahra Razzaghi




Introduction: Intense Pulsed Light (IPL) is one of the effective methods used to treat the signs of facial aging. However, its efficacy in improving the appearance of periorbital wrinkles has always been evaluated in the context of whole-face rejuvenation and not studied in its own right. Therefore, in this study we sought to examine the effectiveness and side effects of IPL in periorbital skin rejuvenation.

Methods: In this uncontrolled, open-label clinical trial, 38 patients referred to the Behrooz professional skin clinic for signs of periorbital skin aging were recruited. Patients underwent three treatment sessions with IPL, at one-month intervals, and were evaluated for treatment side effects after each session. Six months after the final IPL session, patients were examined to assess the level of symptom improvement. Patients were photographed at each treatment session and at the six-month follow-up visit. Before and after patient images were evaluated by two dermatologists unaffiliated with the study to determine the extent of improvement in the appearance of wrinkles and skin texture.

Results: Six months post-treatment, excellent improvement was observed in 3 patients (9.1%), considerable improvement in 7 patients (21.2%), moderate improvement in 9 patients (27.3%), mild improvement in 9 patients (27.3%) and finally little or no improvement was observed in 5 patients (15.1%). Comparison of improvement scores based on Fitzpatrick skin phenotype did not show significant differences (p=0.674). 4 patients (12.1%) were dissatisfied with the treatment whilst 17 patients (51.5%) reported moderate to considerable satisfaction with IPL rejuvenation.

Conclusion: During whole face rejuvenation, IPL can be used to improve periorbital skin aging.



Intense Pulsed Light; Laser; Periorbital; Rejuvenation; Wrinkles


Li D, Lin SB, Cheng B. Intense Pulsed Light: From the Past to the Future. Photomed Laser Surg. 2016;34(10):435-447. doi: 10.1089/pho.2016.4139.

Kohl EA, Babilas P, Landthaler M. Skin rejuvenation with intense pulsed light. Acta Dermatovenerol Croat. 2010;18(3):181-4.

DiBernardo BE, Pozner JN. Intense Pulsed Light Therapy for Skin Rejuvenation. Clin Plast Surg. 2016;43(3):535-40. doi: 10.1016/j.cps.2016.03.008.

Babilas P, Schreml S, Szeimies RM. Intense pulsed light (IPL): a review. Lasers Surg Med. 2010;42(2):93-104. doi: 10.1002/lsm.20877.

Augustyniak A, Rotsztejn H. Intense pulsed light (IPL) treatment for the skin in the eye area – clinical and cutometric analysis. J Cosmet Laser Ther. 2017;19(1):18-24. doi: 10.1080/14764172.2016.1247963.

Sadick NS, Weiss R, Kilmer S, Bitter P. Photorejuvenation with intense pulsed light: results of a multi-center study. J Drugs Dermatol. 2004;3(1):41-9.

Negishi K, Tezuka Y, Kushikata N, Wakamatsu S. Photorejuvenation for Asian skin by intense pulsed light. Dermatol Surg. 2001;27(7):627-31. doi: 10.1046/j.1524-4725.2001.01002.x.

Kligman DE, Zhen Y. Intense pulsed light treatment of photoaged facial skin. Dermatol Surg. 2004;30(8):1085-90. doi: 10.1111/j.1524-4725.2004.30332.x.

Hsu TS, Zelickson B, Dover JS, Kilmer S, Burns J, Hruza G, et al. Multicenter study of the safety and efficacy of a 585 nm pulsed-dye laser for the nonablative treatment of facial rhytides. Dermatol Surg. 2005;31(1):1-9. doi: 10.1097/00042728-200501000-00001

Hardaway CA, Ross EV, Paithankar DY. Non-ablative cutaneous remodeling with a 1.45 microm mid-infrared diode laser: phase II. J Cosmet Laser Ther. 2002;4(1):9-14. doi: 10.1080/14764170260030108.

Weiss RA, McDaniel DH, Geronemus RG, Weiss MA, Beasley KL, Munavalli GM, et al. Clinical experience with light-emitting diode (LED) photomodulation. Dermatol Surg. 2005;31(9):1199-205. doi: 10.1111/j.1524-4725.2005.31926.

Hantash BM, De Coninck E, Liu H, Gladstone HB. Split-face comparison of the erbium micropeel with intense pulsed light. Dermatol Surg. 2008;34(6):763-72. doi: 10.1111/j.1524-4725.2008.34144.x.

Cuerda-Galindo E, Díaz-Gil G, Palomar-Gallego MA, Linares-GarcíaValdecasas R. Intense pulsed light induces synthesis of dermal extracellular proteins in vitro. Lasers Med Sci. 2015;30(7):1931-9. doi: 10.1007/s10103-015-1787-5.

Bedewi AE, Khalafawy GE. The use of synchrotron infrared microspectroscopy to demonstrate the effect of intense pulsed light on dermal fibroblasts. J Cosmet Laser Ther. 2013;15(6):305-9. doi: 10.3109/14764172.2013.769271.

Faucz LL, Will SE, Rodrigues CJ, Hesse H, Moraes AC, Maria DA. Quantitative evaluation of collagen and elastic fibers after intense pulsed light treatment of mouse skin. Lasers Surg Med. 2018;50(6):622-50. doi: 10.1002/lsm.22782.

Feng Y, Zhao J, Gold MH. Skin rejuvenation in Asian skin: the analysis of clinical effects and basic mechanisms of intense pulsed light. J Drugs Dermatol. 2008;7(3):273-9.

Wong WR, Shyu WL, Tsai JW, Hsu KH, Pang JH. Intense pulsed light effects on the expression of extracellular matrix proteins and transforming growth factor beta-1 in skin dermal fibroblasts cultured within contracted collagen lattices. Dermatol Surg. 2009;35(5):816-25. doi: 10.1111/j.1524-4725.2009.01138.x.

Huang J, Luo X, Lu J, Chen J, Zuo C, Xiang Y, et al. IPL irradiation rejuvenates skin collagen via the bidirectional regulation of MMP-1 and TGF-β1 mediated by MAPKs in fibroblasts. Lasers Med Sci. 2011;26(3):381-7. doi: 10.1007/s10103-010-0870-1.

DOI: https://doi.org/10.22037/jlms.v10i4.27624