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Evaluation of gene expression change in eosinophilic gastroenteritis

Mohammad-Mahdi Zadeh-Esmaeel, Mostafa Rezaei –Tavirani, Nayeb Ali Ahmadi, Reza Vafaee
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Abstract

Aim: Screening differentially expressed genes (DEGs) related to Eosinophilic gastroenteritis (EG) to introduce possible biomarkers.

Background: EG as a rare gastrointestinal disorder is characterized with gastrointestinal bleeding, crampy generalized abdominal pain, diarrhea, nausea, vomiting, and weight loss. In this study gene expression profile of patients is analysis via protein-protein interaction (PPI) analysis to reveal new prospective of disease.

Methods: Top significant genes of gene expression profiles of 5 gastric antrum EG patients and 5gastric antrum control from GEO which were matched via boxplot analysis were screened via PPI network by using Cytoscape software and STRING database. Numbers of 20 top nodes of query DEGs based on degree value were introduced as central nodes which 7 critical central genes among them were identified. Gene ontology enrichment for the 20 central genes was done by using CluGO. Action map for the central genes was performed by applying CluePedia.

Results: Among 20 central nodes, TXN, PRDX2, NR3C1, GRB2, PIK3C3, AP2B1 and REPS1 were recognized as critical central genes. Nine biological terms were determined that most of them were involved in the transport processes.

Conclusion: The introduced possible biomarkers can be used in the differential diagnosis of the disease and also in treatment of disorder.

Keywords: Eosinophilic gastroenteritis, gene, protein-protein interaction network.

(Please cite as: Zadeh-Esmaeel MM, Rezaei-Tavirani M, Ahmadi NA, Vafaee R. Evaluation of gene expression change in eosinophilic gastroenteritis. Gastroenterol Hepatol Bed Bench 2019;12(3):239-245).

 


Keywords

Eosinophilic gastroenteritis, gene, protein

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DOI: https://doi.org/10.22037/ghfbb.v12i3.1635