Social factors influencing treatment interruption in Tuberculosis Patients: A qualitative stud

Mustafa Jiba, Fereshteh Zamani-Alavije, Marzieh Araban, Arash Salahshoori, Mobarak Jiba, Javad Haroni



Background and Aims: Positive smear pulmonary Tuberculosis (TB) patients sometimes interrupt their treatment. They may consequently result in the prevalence of antibiotic resistant strains (MDR-TB) in the community. This study was aimed to explore social factors influencing the treatment interruption in these
Materials and Methods: Purposeful sampling method with maximum variance was employed in this qualitative research. Data gathering process were included unstructured in-depth interviews with totally 37 persons (26 patients, 5 their family members and 6 concerning therapy supervisors), patients’ medical records, as well as recorded information in both Tuberculosis register program and Tuberculosis registration office kept in health care centers. Concurrently with data gathering, they were analyzed through ongoing comparisons. Also the participants in the study informed consent was obtained.
Results: Based on the findings of this study, social factors influencing treatment interruption in Tuberculosis patients were included six sub-categories: lack of social support, TB-related stigma, work issues, poverty, as well as imprisonment and drug abuse during the course of treatment.
Conclusion: Results from this study demonstrated that family members and therapy supervisors need appropriate interventions in order to decrease social factors influencing treatment interruption in Tuberculosis
Key words: Social Factors, Tuberculosis Treatment Interruption, Qualitative Study

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Venkatapraveen A, Rampure M, Patil N, Shivanand S. Assessment of clinical pharmacist intervention to improve compliance and health care outcomes of tuberculosis patients. Der Pharmacia Lettre 2012;4(3):931-7.

Mahshid N, Myrhqany L. Guidelines national TB . Tehran: Andishmand; 2010;p: 9.(in persian).

Haasnoot PJ, Boeting TE, Kuney MO, Roosmalen JV. Knowledge, Attitudes, and Practice of Tuberculosis among Maasai in Simanjiro District, Tanzania.Am J Trop Med Hyg 2010;83(4):902-5

Mphothulo N, Pengpid S, Peltzer K. Factors Associated with Tuberculosis Reinfection and Treatment Failure in Taung Sub-District, South Africa. kamla-raj 2012;6(1):23-30.

Franke MF, Appleton SC, Bayona J, Arteaga F,Palacios E,Liaro K, et al. Risk Factors and Mortality Associated with Default from Multidrug-Resistant Tuberculosis Treatmen. Clin Infect Dis 2008;46(12):1844-51.

Royce s, Khann S, Yadav R, Mao E, Cattamanchi A, Sam S, et al. Identification of multidrug resistance

in previously treated tuberculosis patients: a mixed methods study in Cambodia. int J Tuberc Lung Dis 2014 ;18(11):1299-306.

Gebremariam M, Bjune G, Frich J. Barriers and facilitators of adherence to TB treatment in patients on concomitant TB and HIV treatment: a qualitative study. BMC public health 2010;10(1):651.

Kizub D, Ghali I, Sabouni R, Bourkadi J, Bennani K, El Aouad R, et al. Qualitative study of perceived causes of tuberculosis treatment default among health care workers in Morocco. The International Journal of Tuberculosis and Lung Disease 2012;16(9):1214-20.

Tadesse T, Demissie M, Berhane Y, Kebede Y, Abebe M. Long distance travelling and financial burdens discourage tuberculosis DOTs treatment initiation and compliance in Ethiopia: a qualitative study. BMC public health. 2013;13(1):424.

Organization WH. consolidated action plan to prevent and combat multidrug and extensively drugresistant tuberculosis in the WHO European Pegion 2011-2015. Regional Committee for Europe, Baku,Azerbaijan. 2011 September; p:2-3.

Abbasi A, Arabi M. The efficacy of DOTS strategy in treatment or failure of treatment in respiratory Tuberculosis J Gorgan Uni Med Sci 2004;6(1):78-82.

Alavi S, Salami N. The causes and Risk factors of tuberculosis Deaths in Khusestan. Acta Medica Iranica 2009;47(2):89-92.(in persian)

Hargreaves J, Boccia D, Evans C, Adato M, Petticrew M, Porter J. The social determinants of tuberculosis: from evidence to action. Journal of Public Health 2011;101(4):654-62.

Lonnroth K, Castro K, Chakaya J, Chauhan L, Floyd K, Glaziou P, et al. Tuberculosis control and elimination 2010–50: cure, care,and social development. Thelancet 2010;375:1814-29.

Dinwall R, Murphy E, Watson P, Greatbatch D, Parker S. catching goldfish:quality in qualitative research. J Health Serv Res Policy 199;3(3):167-72.

Zamani A, Niknami S, Mohammadi I, Montazeri A. Design and evaluation of an educational model to prevent risky behaviors leading to injury in motorcycle riders. PhD Thesis, School of Medical Sciences, Tarbiat Modarres University. 2009; p: 27-45./34

Polit D, Beck C. Nursing Research: Principle and Methods. Lippincott Williams & Wilkins. Philadelphia. PA USA 2003;7:305-8.

poorasl M, Rostami F, Ivanbagha R, Torabi S. Prevalence of unwanted pregnancy and multivariate analysis of its correlates in Tabriz city 2004. Med Sci J Islam Azad Uni Tehran Med Branch 2005;15(4):201-6.

Streubert Speziale H, Carpenter Dona R. Qualitative Research in nursing:advancing the humanistic imperative, 4th ed. Lippincott Williams & Wilkins 2006; p:133-51.

Story A, Murad S, Roberts W, Verheyen M, Hayward A. Tuberculosis in London: the importance of homelessness,problem drug use and prison. Thorax 2007;62(8):667-71.

Munir M, Iqbal R, Shabbir I, Chaudhry K. Factors Responsible for Failure to Initiate Tuberculosis Treatment among Smear Positive Tuberculosis Patients. Pakistan Journal of Medical Research 2012;51(2):34-7.

Kaona F, Tuba M, Siziya S, Sikaona L. An assessment of factors contributing to treatment adherence and knowledge of TB transmission among patients on TB treatment. BMC Public Health 2004;4(68):2-8.

Finlay A, Lancaster J, Holtz T, Weyer K, Miranda A, van der Walt M. Patient- and provider-level risk factors associated with default from tuberculosis treatment, SouthAfrica, 2002: a case-control study. BMC Public Health 2012; p: 1-12.

Mishra P, Hansen E, Sabroe S, Kafle K. Socio-economic status and adherence to tuberculosis treatment: a case-control study in a district of Nepal. The International Journal of Tuberculosis and Lung Disease 2005;9(10):1134-9.

Munro S, Lewin S, Smith H, Engel M, Fretheim A, Volmink J. Patient adherence to tuberculosis treatment: a systematic review of qualitative research. PLoS medicine 2007;4(7):238.

Fry R, Khoshnood K, Vdovichenko E, Granskaya J, Sazhin V, Shpakovskaya L, et al. Barriers to completion of tuberculosis treatment among prisoners and former prisoners in St Petersburg, Russia. The International Journal of Tuberculosis and Lung Disease 2005;9(9):1027-33.

Sengupta S, Pungrassami P, Balthip Q, Strauss R, Kasetjaroen Y, Chongsuvivatwong V, et al. Social impact of tuberculosis in southern Thailand: views from patients, care providers and the community. The International Journal of Tuberculosis and Lung Disease 2006;10(9):1008-12.


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