Penile Enhancement Using Biodegradable Scaffolds Covered with Platelet-rich Plasma-Fibrin Glue, Mesenchymal Stem Cells for Micropenis
Urology Journal,
Vol. 21 No. 02 (2024),
24 March 2024
,
Page 126-132
https://doi.org/10.22037/uj.v20i.7915
Abstract
Purpose: Evaluation of preliminary cosmetic and functional outcomes of biodegradable scaffolds covered with
platelet-rich plasma in penile girth augmentation.
Materials and Methods: Between June 2016 and June 2018, 36 males who had a mean age of 28.91 years (range
20 - 48 years) with micropenis underwent this procedure. A mixture of platelets-fibrin glue and mesenchymal cells
obtained from dermal fat tissue were prepared. Then the mixture was seeded on the pretreated tube-shaped poly
lactic-co-glycolic acid scaffold and underwent a whole day of incubation. Following penile degloving, scaffolds
were surgically implanted within the interface region of dartos and Buck's fascia. The 5-point Likert scoring scale
was used to evaluate the patients’ satisfaction with surgery.
Results: Patients followed up for 6-12 (8 ± 2.86) months. The penile length in an erected state before surgery was
6.5 - 12.5 cm (9.08 ± 1.6) which enhanced to 7 - 14 cm (10.59 ± 1.71) after surgery (P < .0001). The penile girth
before and after surgery were 8.49 ± 1.53 and 10.91 ± 1.96 cm, respectively (P < .0001). An augment in penile
length and girth of 1.5 and 2.6 cm were achieved, respectively. Patients appraised surgical intervention on a rating
of one to five. The highest possible score (5) was assigned by 27 %, 33 % expressed a very good mark (4), and 19
% gave a good mark (3).
Conclusion: Covering the scaffold with a mixture of Platelets-Fibrin glue and mesenchymal cells seems a safe and
feasible method for penile reconstruction surgery. More studies should be done to determine the effect of platelets-
fibrin glue and mesenchymal cells for treating micropenis.
- Small penis syndrome
- Girth enhancement
- Tissue engineering
- platelet-rich plasma-fibrin glue
- Patients’ satisfaction
How to Cite
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