Comparison of Ibuprofen with Ketorolac on the Control of Renal Colic Pain: A Meta-Analysis of Randomized Controlled Studies
Urology Journal,
Vol. 20 No. 06 (2023),
26 December 2023
,
Page 379-384
https://doi.org/10.22037/uj.v20i.7572
Abstract
Purpose: The comparison of ibuprofen with ketorolac remains controversial for the pain control of renal colic. We
therefore conduct this meta-analysis to compare the analgesic efficacy of ibuprofen with ketorolac for renal colic.
Methods: We have searched PubMed, EMbase, Web of science, EBSCO, and Cochrane library databases through
December 2022 for randomized controlled trials (RCTs) assessing the analgesic efficacy of ibuprofen in comparison
with ketorolac for renal colic. This meta-analysis was performed using the random-effect or fixed-effect model
based on the heterogeneity.
Results: Four RCTs were included in the meta-analysis. In patients with renal colic pain, intravenous ibuprofen
and ketorolac produced comparable pain scores at 15 min (MD = -0.46; 95% CI = -1.24 to 0.31; P = 0.24), 30 min
(MD = -0.81; 95% CI = -1.75 to 0.31; P = 0.09), 60 min (MD=-0.63; 95% CI = -1.40 to 0.13; P = 0.10) and 120
min (MD = -0.74; 95% CI = -2.18 to 0.70; P = 0.31), as well as adverse events (OR = 0.95; 95% CI = 0.61 to 1.49;
P = 0.83).
Conclusion: Ibuprofen can obtain comparable analgesic efficacy to ketorolac for renal colic pain.
- renal colic pain, ibuprofen, ketorolac, pain control, randomized controlled trials
How to Cite
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