Integrative Analysis of Androgen Receptor Interactors Aberrations and Associated Prognostic Significance in Prostate Cancer
Urology Journal,
Vol. 20 No. 05 (2023),
23 October 2023
,
Page 318-328
https://doi.org/10.22037/uj.v20i.7469
Abstract
Purpose: Much progress has been made by directing against the adrogen receptor (AR) pathway in the treatment
of prostate cancer in past decades. However, AR-interactors related metastatic castration resistant prostate cancer
eventually developed. Here, we aimed to characterize the aberrations and therapeutic implication in advanced
disease.
Materials and Methods: STRING database, UALCAN web portal and cBioPortal platform was used to analyze
the AR interaction network, gene alterations, as well as the prognostic significance. GO and KEEG analysis was
performed to characterize the functional enrichment of the identified AR-interactors.
Results: Ten first shell AR-interactors were identified, among of which FOXA1 and PELP1 was significantly
up-regulated, while CCND1, CTNNB1, NCOA4 and HSP90AA1 exhibited a significantly decreased pattern. The
median survival period of altered group (n = 227) was 70 months (95% CI, 60-105M), while that of non-altered
group (n = 545) was 141 months (95% CI, 115.13-NA, P < 0.001). GO and KEGG enrichment showed that the
identified AR-interactors were particularly enriched in prostate cancer and thyroid hormone signaling pathway, as
well as endocrine resistance.
Conclusion: The AR-interactors might be useful markers for prostate cancer diagnosis and prognosis, and provide
a new sight for revealing the molecular mechanism of CRPC progression.
- androgen receptor, prostate cancer, interactors, castration-resistance
How to Cite
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