Urology and Nephrology Research Center, Shahid Beheshti University of Medical Sciences
  • Register
  • Login

Urology Journal

  • Home
  • Instant Online
    • Instant 2023
    • Instant 2022
    • Instant 2021
    • Instant 2020
  • Current
  • Archives
  • Announcements
  • Submissions
  • Author Guidelines
  • About
    • About the Journal
    • Privacy Statement
    • Contact
Advanced Search
  1. Home
  2. Archives
  3. Vol. 19 No. 04 (2022): July-August 2022
  4. UNCLASSIFIED

ISSN: 1735-1308

July-August 2022
Vol. 19 No. 04 (2022)

Efficiency of Hyperbaric Oxygen Therapy Combined with Negative-Pressure Wound Therapy in the Treatment Strategy of Fournier’s Gangrene –A Retrospective Study

  • Łukasz Michalczyk
  • Agnieszka Grabińska
  • Beata Banaczyk
  • Marek Braszko
  • Aneta Andrychowicz
  • Tomasz Ząbkowski

Urology Journal, Vol. 19 No. 04 (2022), , Page 329-332
https://doi.org/10.22037/uj.v18i.6797 Published 16 August 2021

  • View Article
  • Download
  • Cite
  • References
  • Statastics
  • Share

Abstract

Purpose: Fournier’s gangrene (FG) is a serious, aggressive, and often fatal multi-organism infection that affects the soft tissues of the perineum, rectum, and external genitalia. This study aimed to analyse the treatment’s strategies of FG.


Materials and Methods: This was a retrospective study of 35 patients with a diagnosis of FG admitted between 2016 and 2021. The diagnosis of FG was established on a clinical basis. Data on patient’s age, sex, comorbidities, laboratory results (C-reactive protein (CRP), white blood cell (WBC), hematocrit (HCT), platelets (PLT), sodium, potassium, creatinine, procalcitonin, international normalized ratio (INR), and gangrene culture), extent of resection, antibiotics used, and hospitalisation time were obtained. The extent of resection was assessed on a scale of 1–5.


Results: The study group consisted of all men (n=35) aged 24–85 (mean, 58) years. In 13/35 (37%) patients, hyperbaric oxygen therapy (HBOT) combined with negative-pressure wound therapy (NPWT) was used as a treatment for wound healing in Fournier’s syndrome (group 1), and in 22/35 (63%) patients, open standard wound care was used (group 2). There were no fatalities in group 1, but four deaths (18%) were noted in group 2. The median extent of resection was 3 in group 1 and 2 in group 2. There was a correlation between the extent of resection and use of HBOT combined with NPWT. The hospitalisation time was much shorter in group 2 (mean, 23 days) than in group 1 (mean, 26 days).


Conclusion: HBOT and NPWT (group 1) showed advanced wound healing with a high efficiency rate. The longer median hospitalisation time in this group may be related to the severity of injury. 

Keywords:
  • Fournier’s gangrene, treatment, wound therapy
  • 6797/pdf

How to Cite

Michalczyk, Łukasz, Grabińska, A., Banaczyk, B., Braszko, M., Andrychowicz, A., & Ząbkowski, T. (2021). Efficiency of Hyperbaric Oxygen Therapy Combined with Negative-Pressure Wound Therapy in the Treatment Strategy of Fournier’s Gangrene –A Retrospective Study. Urology Journal, 19(04), 329-332. https://doi.org/10.22037/uj.v18i.6797
  • ACM
  • ACS
  • APA
  • ABNT
  • Chicago
  • Harvard
  • IEEE
  • MLA
  • Turabian
  • Vancouver
  • Endnote/Zotero/Mendeley (RIS)
  • BibTeX

References

1. Ming-Chan H, Chia-Lin C, Li-Chin C, Chung-Han H, Ko-Chi N, Hsien-Lin C, et al. The role of hyperbaric oxygen therapy in treating extensive Fournier's gangrene. Urological Science 2016; 27(3): 148-153.
2. Schneidewind L, Anheuser P, Schönburg S, Wagenlehner F, M, E, Kranz J: Hyperbaric Oxygenation in the Treatment of Fournier’s Gangrene: A Systematic Review. Urol Int 2020.
3. Krishna Gowtham V, Vaishnavi A, Bhargav Narendra J. Case Report on Fournier’s Gangrene. World Journal of Current Medical and Pharmaceutical Research 2020; 2(2): 191-193.
4. Wilkinson D, Doolette D. Hyperbaric oxygen treatment and survival from necrotizing soft tissue infection. Arch. Surg. 2004; 139: 1339–1345.
5. Kirby J. Hyperbaric Oxygen Therapy and Negative Pressure as Advanced Wound Management. Mo Med. 2019;116(3):192-194.
6. Hong KS, Yi HJ, Lee RA, Kim KH, Chung SS. Prognostic factors and treatment outcomes for patients with Fournier’s gangrene: a retrospective study. Int Wound J. 2017;14:1352–8.
7. Unalp HR, Kamer E, Derici H, Atahan K, Balci U, Demirdiven C, et al. Fournier’s gangrene: Evaluation of 68 patients and analysis of prognostic variables. J Postgrad Med 2008;54:102-5.
8. Li C, Zhou X, Liu LF, Qi F, Chen JB, Zu XB. Hyperbaric Oxygen Therapy as an Adjuvant Therapy for Comprehensive Treatment of Fournier's Gangrene. Urol Int 2015; 94: 453-458.
9. Tutino R, Colli F, Rizzo G, et al. Which role of hyperbaric oxygen therapy in the treatment of Fournier’s gangrene? A retrospective study. Research Square 2020: 1-15.
10. Assenza M, Cozza V, Sacco E, et al. VAC (Vacuum Assisted Closure) treatment in Fournier’s gangrene: personal experience and literature review. Clin Ter 2011;162:1-5. 13.
11. Cuccia G, Mucciardi G, Morgia G, et al. Vacuum-assisted closure for the treatment of Fournier’s gangrene. Urol Int 2009;82:426-431.
12. Bali ZU, Akdeniz CB, Müezzinoğlu T, Üçer O, Kara E. Comparison of Standard Open Wound Care and Vacuum-assisted Closure Therapy in Fournier’s Gangrene J Urol Surg 2020;7(1):42-45.
  • Abstract Viewed: 0 times
  • 6797/pdf Downloaded: 0 times

Download Statastics

  • Linkedin
  • Twitter
  • Facebook
  • Google Plus
  • Telegram

In case of persistent problems in registration, primary uploading of a submission or uploading of a revision, please send us the submission files on the journal email at:

urologyjournal@sbmu.ac.ir

and please attach the screenshot of the error or problem you encountered in uploading.

 

Make a Submission

          Journal Research in Urology

Information
  • For Readers
  • For Authors
Keywords
  • Home
  • Archives
  • Submissions
  • About the Journal
  • Editorial Team
  • Contact
The template of this website is designed by Sinaweb