Interferential Electrical Stimulation Efficacy in the Management of Lower Urinary Tract Dysfunction in Children: A Review of the Literature
Vol. 18 No. 05 (2021),
7 November 2021
Background: Lower urinary tract dysfunction (LUTD) is the most common problem of the referral children to the pediatric urology clinics. If this condition does not treat early in life, it will be a lifelong problem. During recent decades, electrical stimulation therapy has been expanded and extensively used for the treatment of LUTD in both adults and children. The aim of this review is to suggest clinicians an updated understanding of effects of interferential (IF) electrical stimulation therapy in management of LUTD in children.
Materials and methods: The search was performed in databases of Medline, PubMed, Google Scholar, ,and Scopus for information about IF electrical stimulation and its application using search words such as “ IF electrical stimulation”, “transcutaneous IF electrical stimulation” , “IF therapy ” , “ electrical stimulation”, “voiding dysfunction” , “ LUTD”, “ urinary incontinence” and “ children”. As this review focuses on the answer of this question “Does transcutaneous IF electrical stimulation has effect on management of LUTD in children?” we included the reference list of articles identified by this search strategy and selected those we judged relevant according to our keywords. Clinical trial studies that publishing in English were included. Categorical data were reported as frequencies and percentages.
Results: Eleven studies were included in this review. The success rate of IF therapy in these studies has been reported from 61% to 90% of children with LUTD and urinary incontinence.
Conclusion: IF electrical stimulation is an effective, safe and reproducible option to manage LUTD and urinary incontinence in children.
- Electrical stimulation; children; lower urinary tract dysfunction; urinary incontinence
How to Cite
2. Berry A, Rudick K, Richter M, Zderic S. Objective versus subjective outcome measures of biofeedback: what really matters? J Pediatr Urol. 2014; 10(4):620-6. doi:10.1016/j.jpurol.2014.06.003.
3. Ferrara P, D’Aleo CM, Tarquini E, Salvatore S, Salvaggio E, et al. Side effects of oral or intravesical oxybutynin chloride in children with spina bifida. BJU Int. 2001; 87(7):674–8.
4. Krzemińska K, Maternik M, Drożyńska-Duklas M, Szcześniak P, Czarniak P, et al. High efficacy of biofeedback therapy for treatment of dysfunctional voiding in children. Cent European J Urol. 2012;65(4):212-5. doi: 10.5173/ceju.2012.04.art6.
5. Tugtepe H, Thomas DT, Ergun R, Kalyoncu A, Kaynak A, et al. The effectiveness of transcutaneous electrical neural stimulation therapy in patients with urinary incontinence resistant to initial medical treatment or biofeedback. J Pediatr Urol. 2015 Jun;11(3):137.e1-5. doi: 10.1016/j.jpurol.2014.10.016.
6. Barroso UJr, Tourinho R, Lordelo P, Hoebeke P, Chase J. Electrical stimulation for lower urinary tract dysfunction in children: a systematic review of the literature. Neurourol Urodyn. 2011;30(8):1429-36. doi:10.1002/nau.21140.
7. Schreiner L, Santos TG, Souza AB, Campani Nygaard C, da Silva Filho IG. Electrical stimulation for urinary incontinence in women: a systematic review. Int Braz J Urol. 2013;39(4):454-64. doi:10.1590/s1677-5538.Ibju.2013.04.02.
8. Robinson A, Snyder-Mackler L. Clinical electrophysiology: electrotherapy and electrophysiologic testing 3rd ed. Baltimore: Lippincott Williams and Wilkins, 2008;151-196, 198-237, 239-274.
9. Bower WF, Yeung CK. A review of non-invasive electro neuromodulation as an intervention for non-neurogenic bladder dysfunction in children. Neurourol Urodyn. 2004;23(1):63-7.
10. Capitanucci ML, Camanni D, Demelas F, Mosiello G, Zaccara A, et al. Long-term efficacy of percutaneous tibial nerve stimulation for different types of lower urinary tract dysfunction in children.J Urol. 2009 Oct;182(4 Suppl):2056-61. doi: 10.1016/j.juro.2009.03.007.
11. Sillén U, Arwidsson C, Doroszkiewicz M, H Antonsson , I Jansson, et al. Effects of transcutaneous neuromodulation (TENS) on overactive bladder symptoms in children: a randomized controlled trial.J Pediatr Urol. 2014 Dec;10(6):1100-5. doi: 10.1016/j.jpurol.2014.03.017.
12. Malm-Buatsi E, Nepple KG, Boyt MA, Austin JC, Cooper CS. Efficacy of transcutaneous electrical nerve stimulation in children with overactive bladder refractory to pharmacotherapy. Urology. 2007 Nov;70(5):980-3.
13. de Oliveira LF, de Oliveira DM, da Silva de Paula LI, de Figueiredo AA, José de Bessa Jr, et al. Transcutaneous parasacral electrical neural stimulation in children with primary monosymptomatic enuresis: a prospective randomized clinical trial.J Urol. 2013 Oct;190(4):1359-63. doi: 10.1016/j.juro.2013.03.108
14. Southwell BR. Electro-Neuromodulation for Colonic Disorders-Review of Meta-Analyses, Systematic Reviews, and RCTs. Neuromodulation. 2020. doi: 10.1111/ner.13099. Online ahead of print.
15. Tan AYF, Sourial M, Hutson JM, Southwell BR. Tan AYF, et al. Short-Term Interferential Transabdominal Electrical Stimulation Did Not Change Oral-Rectal Transit Time in Piglets. Neuromodulation. 2018 Oct;21(7):669-675. doi: 10.1111/ner.12761.
16. Chase J, Robertson VJ, Southwell B, Hutson J, Gibb S. Pilot study using transcutaneous electrical stimulation (interferential current) to treat chronic treatment-resistant constipation and soilingin children. J. Gastroenterol. Hepatol. 2005; 20(7), 1054–1061
17. Goats GC. Interferential current therapy.Br J Sports Med. 1990 Jun;24(2):87-92.
18. Ariel E, Ratmansky M, Levkovitz Y, Goor-Aryeh I. Efficiency of tissue penetration by currents induced by three electrotherapeutic techniques: A comparative study using a novel deep-tissue measuring technique. Phys Ther. 2019 May 1;99(5):540-548. doi: 10.1093/ptj/pzz005.
19. Ozcan J, Ward AR, Robertson VJ. A comparison of true and premodulated interferential currents. Arch Phys Med Rehabil 2004;85:409-415
20. Ward AR. Electricity Fields and Waves in Therapy Science Press, 1980. Marrickville, NSW, Australia
21. Bounyong S, Adachi S, Yoshimoto T, Ota T, Ozawa J. Controlling interfered area in interferential current stimulation by electrode-area patterning. Conf Proc IEEE Eng Med Biol Soc. 2016 Aug;2016:1721-1724. doi: 10.1109/EMBC.2016.7591048.
22. Moore JS, Gibson PR, Burgell RE. Neuromodulation via Interferential Electrical Stimulation as a Novel Therapy in Gastrointestinal Motility Disorders. J Neurogastroenterol Motil. 2018 Jan 30;24(1):19-29. doi: 10.5056/jnm17071.
23. Palmer ST, Martin DJ, Steedman WM, Ravey J. Alteration of interferential current and transcutaneous electrical nerve stimulation frequency: effects on nerve excitation. Arch Phys Med Rehabil 1999;80:1065-1071.
24. Yamanishi T, Kamai T,Yoshida KI. Neuromodulation for the treatment of urinary incontinence. International Journal of Urology.2008; 15, 665–672. doi: 10.1111/j.1442-2042.2008.02080.
25. Dougall DS. The effects of interferential therapy on incontinence and frequency of micturition. Physiotherapy 1985, 71 (3), 135-136.
26. Caldwell KP. The electrical control of sphincter incompetence. Lancet. 1963;2:174-175.
27. Kajbafzadeh AM, Sharifi-Rad L, Baradaran N, Nejat F. Effect of pelvic floor interferential electrostimulation on urodynamic parameters and incontinency of children with myelomeningocele and detrusor overactivity. Urology. 2009 Aug;74(2):324-9. doi: 10.1016/j.
28. Ghaderi F, Oskouei AE. Physiotherapy for women with stress urinary incontinence: a review article. J Phys Ther Sci. 2014 Sep;26(9):1493-9. doi: 10.1589/jpts.26.1493.
29. Laycock, J, Green RJ. Interferential therapy in the treatment of incontinence. Physiotherapy 1988, 74 (4), 161-168.
30. Oh-Oka H. Efficacy of interferential low frequency therapy for elderly wet overactive bladder patients. Indian J Urol 2008;24:178-181
31. Andersson KE. Bladder activation: Afferent mechanism. Urology. 2002;59:43–50.
32. Sylvester KL, Keilty SEJ. A pilot study to investigate the use of interferential in the treatment of ano-rectal incontinence. Physiotherapy 1987, 73 (4), 207-208.
33. Raj P, Sarin YK, Raj P. Role of Interferential Therapy in Children with Fecal Incontinence Postanorectal Malformation Surgeries. J Indian Assoc Pediatr Surg. 2017 Apr-Jun;22(2):92-95. doi: 10.4103/0971-9261.202678.
34. MacDonagh RP, Sun WM, Smallwood R, Forster D, Read NW. Control of defecation in patients with spinal injuries by stimulation of sacral anterior nerve roots. BMJ , 1990, 300(6738), 1494–1497.
35. Koklu S, Koklu G, Ozguclu E, Kayani GU, Akbal E, et al. Clinical trial: interferential electric stimulation in functional dyspepsia patients – a prospective randomized study. Aliment. Pharmacol.Ther. 2010; 31(9), 961–968
36. Coban S, Akbal E, Koklu S, Köklü G, Ulaşlı MA, et al. Clinical trial: transcutaneous interferential electrical stimulation in individuals with irritable bowel syndrome – a prospective double-blind randomized study. Digestion 2012; 86(2), 86–93
37. Sharifi-Rad L, Ladi-Seyedian SS, Manouchehri N, Alimadadi H, Allahverdi B, et al. Effects of Interferential Electrical Stimulation Plus Pelvic Floor Muscles Exercises on Functional Constipation in Children: A Randomized Clinical Trial. Am J Gastroenterol. 2018 Feb;113(2):295-302. doi: 10.1038/ajg.2017.459.
38. Kajbafzadeh AM, Sharifi-Rad L, Nejat F, Kajbafzadeh M, Talaei HR. Transcutaneous interferential electrical stimulation for management of neurogenic bowel dysfunction in children with myelomeningocele. Int. J. Colorectal Dis. 2012; 27(4):453–458
39. Mauroy B, Devillers P, Demetriou D, Ametepe B, Biserte J. Treatment of bladder instability with interferential current. Report of 20 cases: preliminary results. Prog Urol. 1992 Aug-Sep; 2(4):664-70. [Article in French]
40. Yazdanpanah P, Mousavizadeh A , Mehrabi S. Assessment of Interferential Currents Therapy Efficacy in Management of Primary Nocturnal Enuresis in 5-15 Years Old Children: A Randomized Clinical Trial. J Nov Physiother 2012, 2:3.
41. Lee HE, Park K. Efficacy of salvage interferential electrical stimulation therapy in patients with medication-refractory enuresis: a pilot study. Int Neurourol J 2013;17:139-144.
42. Kajbafzadeh AM, Sharifi-Rad L, Mozafarpour S, Ladi-Seyedian SS. Efficacy of transcutaneous interferential electrical stimulation in treatment of children with primary nocturnal enuresis: a randomized clinical trial. Pediatr Nephrol. 2015 Jul;30(7):1139-45. doi: 10.1007/s00467-014-3039-5
43. Kajbafzadeh AM, Sharifi-Rad L, Ladi-Seyedian SS, Mozafarpour S. Transcutaneous interferential electrical stimulation for the management of non-neuropathic underactive bladder in children: a randomised clinical trial. BJU Int. 2016 May;117(5):793-800. doi: 10.1111/bju.13207.
44. Zivkovic VD, Stankovic I, Dimitrijevic L, Kocic M, Colovic H, et al. Are Interferential Electrical Stimulation and Diaphragmatic Breathing Exercises Beneficial in Children With Bladder and Bowel Dysfunction? Urology. 2017 Apr;102:207-212. doi: 10.1016/j.urology.2016.12.038.
45. Rafaqat A, Sattar MI, Hafeez M, et al. The Effectiveness of Interferential Current on Overactive Bladder Syndrome. J Nov Physiother 2017, 7:3 DOI: 10.4172/2165-7025.10003
46. Ladi-Seyedian SS, Sharifi-Rad L, Kajbafzadeh AM. Pelvic floor electrical stimulation and muscles training: a combined rehabilitative approach for management of non-neuropathic urinary incontinence in children. J Pediatr Surg. 2019 Apr;54(4):825-830. doi: 10.1016/j.jpedsurg.2018
47. Sharifi-Rad L, Ladi Seyedian SS, Fatemi-Behbahani SM, Lotfi B, Kajbafzadeh AM. Impact of transcutaneous interferential electrical stimulation for management of primary bladder neck dysfunction in children. J Pediatr Urol. 2020 Feb;16(1):36.e1-36.e6. doi: 10.1016/j.jpurol.2019.10.004.
48. Abdelhalim NM, Ibrahim MM. A comparative study of transcutaneous interferential electrical stimulation and transcutaneous electrical nerve stimulation on children with primary nocturnal enuresis: a randomized clinical trial. Int Urol Nephrol. 2020 Mar;52(3):409-415. doi: 10.1007/s11255-019-02340-w.
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