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  3. Vol. 9 No. 3 (2012): Summer
  4. ORIGINAL PAPER(UROLOGICAL ONCOLOGY)

ISSN: 1735-1308

Summer
Vol. 9 No. 3 (2012)

A Plausible Anti-Apoptotic Role of Up-Regulated OCT4B1 in Bladder Tumors

  • Jamshid Asadzadeh
  • Malek Hossein Asadi
  • Nasser Shakhssalim
  • Mahmoud-Reza Rafiee
  • Hamid Reza Kalhor
  • Mahmoud Tavallaei
  • Seyed Javad Mowla

Urology Journal, Vol. 9 No. 3 (2012), , Page 574-580
https://doi.org/10.22037/uj.v9i3.1595 Published 11 August 2012

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Abstract

PURPOSE: To investigate and compare the expression of OCT4B1 between tumor and non-tumor bladder tissues. MATERIALS AND METHODS: We investigated the expression of OCT4B1 in 30 tumor and non-tumor surgical specimens of the bladder, using the TaqMan real-time polymerase chain reaction approach and by carefully designing primers and probes specific for the amplification of the variant. RESULTS: Most tumor and non-tumor samples of the bladder showed OCT4B1 expression, but its expression level was significantly higher in the tumors (P < .002). Moreover, the up-regulation of OCT4B1 was more significant in high-grade tumors compared to the low-grade ones (P < .05). We have also employed the RNA interference strategy to evaluate the functional role of OCT4B1 in a bladder cancer cell line, 5637. Suppression of OCT4B1 caused some changes in cell cycle distribution, and significantly elevated the rate of apoptosis in the cells. CONCLUSION: Our findings suggest that OCT4B1 plays a potential role in tumor initiation and/or progression of the bladder cancer. Additionally, OCT4B1 can be regarded as a new tumor marker for detection, classification, and treatment of the bladder cancer. However, more experimental studies are needed to replicate our findings.

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How to Cite

Asadzadeh, J., Asadi, M. H., Shakhssalim, N., Rafiee, M.-R., Kalhor, H. R., Tavallaei, M., & Mowla, S. J. (2012). A Plausible Anti-Apoptotic Role of Up-Regulated OCT4B1 in Bladder Tumors. Urology Journal, 9(3), 574-580. https://doi.org/10.22037/uj.v9i3.1595
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