Reduction of plasma levels of E-selectin and P-selectin induced-intensity training in obese boys
Journal of Clinical Physiotherapy Research,
Vol. 10 No. 1 (2025),
15 Aban 2025
Abstract
Background : Obesity is an epidemic problem that cause of atherosclerosis development and increase risk of cardiovascular diseases. Increase of adhesion molecule such as the P-selectin and E-selectin in obese people have key role in atherosclerosis phenomena. The purpose of this study was to investigate of high-intensity and moderate- intensity aerobic training on plasma levels of P-selectin and E-selectin in obese boys. Methods: In the semi-experimental study 36 obese student boys )age 13.4 ± 0.69 years old, height 163.06 ± 7.88 cm and weight 85.72 ± 8.42 kg) were randomly assigned to three groups: high-intensity aerobic training (n= 12), moderate-intensity aerobic training (n= 12) and control (n=12). The training was performed at 50-65% maximal heart rate (moderate-intensity) and 70-85% maximal heart rate (high-intensity), 3 day per week for 10- weeks. The blood sample was collected 48-h before and 48-h after last sessions of exercise training. The P-selectin and E-selectin were measured by ELISA. Data were analyzed using two-way repeated ANOVA with SPPS version 18.Results: The results of tow-way ANOVA analysis indicated that body percent fat (P = 0.028) and body weight (P = 0.042) were significantly decreased after 10- weeks training intervention. There is a significantly decrese of body fat percent and body weight in high-intensity training compared with moderate-intensity training (P= 0.027). The results of tow-way ANOVA analysis indicated that VO2max value significantly increased (P = 0.018). The plasma levels of P-selectin (P=0.001) and E-selectin (P=0.016) were significantly decreased after training intervention. Additionally, there is a significantly decrease of P-selectin in high-intensity training compared with moderate-intensity training (P= 0.034), but there is no significantly different between high-intensity training and moderate-intensity training in plasma levels of E-selectin in obese boys (P> 0.05). Conclusion: It seems that high-intensity aerobic training compared with moderate-intensity training has greater reduction in plasma levels of E-selectin, P-selectin, body weight and BMI, and increase of VO2max.
- aerobic training
- obesity
- atherosclerosis
- adhesion molecule
- inflammation
How to Cite
References
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