Neurological Wilson’s Disease in Adolescents: A Case Series from South India Neurological Wilson’s Disease in Adolescents
International Clinical Neuroscience Journal,
Vol. 12 No. Continuous (2025),
25 January 2026
,
Page e6
https://doi.org/10.22037/icnj.v12iContinuous.50779
Abstract
Wilson’s disease is an autosomal recessive disorder that disrupts copper metabolism, leading to serious consequences in the liver and brain, including cirrhosis and the characteristic Kayser-Fleischer (KF) ring in the cornea. Our study focuses on children who presented with neurological symptoms, with or without hepatic involvement. While there have been a few reports from northern India, data on pediatric cases in southern India are sparse, highlighting the need for more comprehensive research in this region. In this series, we report on nine adolescent children diagnosed with neurological manifestations of Wilson’s disease who presented to a tertiary care center. We collected relevant clinical histories, along with details from physical and neurological examinations, from the medical record system. This comprehensive data collection aimed to provide a clearer understanding of the clinical presentation and progression of neurological Wilson's disease in our patient cohort. Wilson’s disease should be considered as one of the initial differential diagnoses even when there is only one neurological manifestation and without hepatic involvement in adolescents as well.
- Wilson's disease, Neurological manifestations, Kayser - Fleischer ring, adolescents, hepatomegaly
How to Cite
References
1. Marsden CD. Wilson's disease. Quart J Med. 1987;65:959–56. doi: 10.1093/qjmed/65.4.959
2. William F, Ratistrorl. Wilson Disease. In: Behrman J. Danks IJM. Copper and liver disease. Eur J Pediatr. 1991;150:142–8. doi: 10.1007/bf01957261
3. Czlonkowska A, Litwin T, Chabik G. Wilson disease: neurologic features. Handb Clin Neurol. 2017;142:101–19. doi: 10.1016/b978-0-444-63622-5.00009-8
4. Shribman S, Poujois A, Bandmann O, Czlonkowska A, Warner TT. Wilson’s disease: update on pathogenesis, biomarkers and treatments. J Neurol Neurosurg Psychiatry. 2021;92(10):1053–61. doi: 10.1136/jnnp-2020-325222
5. Socha P, Janczyk W, Dhawan A, Baumann U, D'Antiga L, Tanner S, et al. Wilson's disease in children: a position paper. J Pediatr Gastroenterol Nutr. 2018;66:334–44. doi: 10.1097/mpg.0000000000001880
6. Fernando M, van Mourik I, Wassmer E, Kelly D. Wilson disease in children and adolescents. Arch Dis Child. 2020;105:499–505. doi: 10.1136/archdischild-2018-316538
7. Prashanth LK, Taly AB, Sinha S, Arunodaya GR, Swamy HS. Wilson's disease: clinical and laboratory manifestations in 282 patients. J Neurol Sci. 2005;232:13–7. doi: 10.1016/j.jns.2004.12.012
8. Aggarwal A, Chandhok G, Todorov T, et al. Wilson Disease Mutation Update. PLoS One. 2019;14:e0215779. doi: 10.1371/journal.pone.0215779
9. Członkowska A, Litwin T, Dusek P, Ferenci P, Lutsenko S, Medici V, et al. Wilson disease. Nat Rev Dis Primers. 2018;4:21. doi: 10.1038/s41572-018-0018-9
10. Taly AB, Meenakshi-Sundaram S, Sinha S, Swamy HS, Arunodaya GR. Wilson disease: description of 282 patients evaluated over 3 decades. Medicine (Baltimore). 2007;86:112–21. doi: 10.1097/md.0b013e31804245af
11. Walshe JM, Yealland M. Wilson’s disease: the problem of delayed diagnosis. QJM. 1992;85:85–92. doi: 10.1093/qjmed/85.1.85
12. Bhattacharya K, Thankappan B. Wilson's Disease Update: An Indian Perspective. Ann Indian Acad Neurol. 2022;25:43–53. doi: 10.4103/aian.aian_173_22
13. Panagariya A, Sureka RK, Sharma AK, Dev A, Agarwal N. Wilson's disease: A study of 21 cases from north-west India. Ann Indian Acad Neurol. 2007;10:255–8. doi: 10.4103/0972-2327.35974
- Abstract Viewed: 40 times
- PDF Downloaded: 23 times