International Clinical Neuroscience Journal

Vol. 11 No. 1 (2024)

The Relationship between Antiseizure Medications and Sleep Quality Among Epilepsy Patients: A Cross-Sectional Study

International Clinical Neuroscience Journal, Vol. 11 No. 1 (2024), 4 November 2025 , Page e5
https://doi.org/10.22037/icnj.v11i1.43521

Abstract

Background: Poor sleep quality and sleep deprivation provoke epileptic seizures, and sleep-related epilepsy and antiseizure medications (ASMs) affect sleep quality. There is still a limited study exploring the relationship between ASM consumption and the sleep quality of epilepsy patients in developing countries, and this study will be the first one conducted in Indonesia.

Methods: This cross-sectional study was conducted from April to June 2023. Subjects were patients aged 18-65 years old, electro-clinically diagnosed with any epilepsy, who had taken at least one ASM. They were seizure-free for at least three months, without a history of anxiety, depression, poor sleep hygiene, or medication adherence. Sleep quality is measured using the Pittsburgh Sleep Quality Index (PSQI). The Fisher-exact test is used to analyze the association. A p-value of <0.05 is considered statistically significant.

Results: A total of 64 subjects were included, consisting of 33 males (51.6%), with a median age of 37.8 ± 13.8 years. Poor sleep quality was found in 24 subjects (37.5%) with a median PSQI score of 4.8. Older-generation ASMs (p = 0.023), polytherapy (p = 0.02), and ASM use for less than 1 year (p = 0.003) were significantly associated with poor sleep quality.

Conclusions: ASM type, consumption duration, and the number of ASMs are significantly associated with sleep quality. Therefore, routine evaluation of sleep quality and appropriate ASM is recommended for epilepsy patients.

Conclusion: The study will be useful while performing surgical procedures around the axis vertebrae to prevent injury to vital structures.

Keywords:
  • sleep quality
  • PSQI
  • ASM
  • epilepsy
  • Indonesia

How to Cite

1.
Hermawan AKS, Khosama H, Jehosua SY, Pertiwi JM, Karema W, Wariki WMV. The Relationship between Antiseizure Medications and Sleep Quality Among Epilepsy Patients: A Cross-Sectional Study. Int Clin Neurosci J [Internet]. 2025 Nov. 4 [cited 2026 Jul. 5];11(1):e5. Available from: https://journals.sbmu.ac.ir/neuroscience/article/view/43521

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