Neurological Manifestation of COVID-19: A Literature Review
International Clinical Neuroscience Journal,
Vol. 7 No. 4 (2020),
28 September 2020
,
Page 164-170
Abstract
In December 2019, the coronavirus ((COVID-19) outbreak related to severe acute respiratory syndrome (SARS-CoV2) originated in China and expanded exponentially as a public health pandemic to over 200 countries. Over 8 million validated cases and approximately 800 000 deaths. The main type is cardiac and respiratory but neurological symptoms are further mentioned as case series and case records in the research. The most frequent manifestations have been reported to include dizziness and headache followed by delirium and encephalopathy. Gillian barre syndrome, acute transversal myelitis, cerebrovascular accident, and encephalitis are among the complications noted. The most prominent occurrence at the periphery was hyposmia. This is also known that neurological demonstrations will also lead to regular features such as cough and fever, which evolve in these cases later on normal manifestations. For the timely diagnosis and separation of cases, therefore, a great suspicion guide is needed to arrest spread in neurology departments. This research provides a narrative study of COVID-19’s neurological symptoms and complexities. Our goal is to inform the neurologists and clinicians who work amidst potential COVID-19 patients regarding potential neurological symptoms, and likely neurological problems arising from the aforementioned new virus.
Keywords:
- COVID-19
- Neurology
- Nervous system
- SARS-CoV-2
- Stroke
How to Cite
1.
Azhideh A, Menbari-Oskouie I, Yousefi-Asl M. Neurological Manifestation of COVID-19: A Literature Review. Int Clin Neurosci J [Internet]. 2020 Sep. 28 [cited 2024 Dec. 9];7(4):164-70. Available from: https://journals.sbmu.ac.ir/neuroscience/article/view/31811
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13- Lou J, Tian SJ, Niu SM, Kang XQ, Lian HX, Zhang LX, et al. Coronavirus disease 2019: a bibliometric analysis and review. Eur Rev Med Pharmacol Sci 2020;24 (6):3411–21.
14- Wu Yeshun, Xu Xiaolin, Chen Zijun, Duan Jiahao, Hashimoto Kenji, Yang Ling, Liu Cunming, Yang Chun. Nervous system involvement after infection with COVID-19 and other coronaviruses. Brain Behav Immun 2020. https://doi.org/ 10.1016/j.bbi.2020.03.031.
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16- Baig AM, Khaleeq A, Ali U, Syeda H. Evidence of the COVID-19 virus targeting the CNS: tissue distribution, host virus interaction, and proposed neurotropic mechanisms. ACS Chem Neurosci 2020 Apr 1;11(7):995–8.
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19- Filatov A, Sharma P, Hindi F, et al. Neurological complications of coronavirus disease (COVID-19): encephalopathy. Cureus 2020;12(3):e7352. https://doi. org/10.7759/cureus.7352.
20- Chen T, Wu D, Chen H, Yan W, Yang D, Chen G, et al. Clinical characteristics of 113 deceased patients with coronavirus disease 2019: retrospective study. BMJ 2020;368:m1091. https://doi.org/10.1136/bmj.m1091. Erratum in: BMJ. 2020 Mar 31;368:m1295.
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22- Zhao K, Huang J, Dai D, Feng Y, Liu L, Nie S. Acute myelitis after SARS-CoV-2 infection: a case report. medRxiv 2020.
23- Sharifi-Razavi A, Karimi N, Rouhani N. COVID 19 and intra cerebral hemorrhage: causative or coincidental. New Microbes New Infect 2020 Mar;27:100669.
24- Moriguchi Takeshi, Harii Norikazu, Goto Junko, Harada Daiki, Sugawara Hisanori, Takamino Junichi, Ueno Masateru, Sakata Hiroki, Kondo Kengo, Myose Natsuhiko, Nakao Atsuhito, Takeda Masayuki, Haro Hirotaka, Inoue Osamu, Suzuki-Inoue Katsue, Kubokawa Kayo, Ogihara Shinji, Sasaki Tomoyuki, Kinouchi Hiroyuki, Kojin Hiroyuki, Ito Masami, Onishi Hiroshi, Shimizu Tatsuya, Sasaki Yu, Enomoto Nobuyuki, Ishihara Hiroshi, Furuya Shiomi, Yamamoto Tomoko, Shimada Shinji. A first case of meningitis/ encephalitis associated with SARS-Coronavirus-2. Int. J. Infectious Dis. 2020;94:55–8. https://doi.org/10.1016/j.ijid.2020.03.062.
25- Huang Chaolin, Wang Yeming, Li Xingwang, Ren Lili, Zhao Jianping, Hu Yi, Zhang Li, Fan Guohui, Xu Jiuyang, Gu Xiaoying, Cheng Zhenshun, Yu Ting, Xia Jiaan, Wei Yuan, Wu Wenjuan, Xie Xuelei, Yin Wen, Li Hui, Liu Min, Xiao Yan, Gao Hong, Guo Li, Xie Jungang, Wang Guangfa, Jiang Rongmeng, Gao Zhancheng, Jin Qi, Wang Jianwei, Cao Bin. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Lancet 2020;395 (10223):497–506. https://doi.org/10.1016/S0140-6736(20)30183-5.
26- Deng Yan, Liu Wei, Liu Kui, Fang Yuan-Yuan, Shang Jin, zhou Ling, Wang Ke, Leng Fan, Wei Shuang, Chen Lei, Liu Hui-Guo. Clinical characteristics of fatal and recovered cases of coronavirus disease 2019 (COVID-19) in Wuhan, China: a retrospective study. Chin Med J 2020:1. https://doi.org/10.1097/ CM9.0000000000000824.
27- Li Long-quan, Huang Tian, Wang Yong-qing, Wang Zheng-ping, Liang Yuan, Huang Tao-bi, Zhang Hui-yun, Sun Weiming, Wang Yuping. COVID-19 patients’ clinical characteristics, discharge rate, and fatality rate of meta- analysis. J Med Virol 2020;92(6):577–83. https://doi.org/10.1002/jmv.v92.6.
28- Yan CH, Faraji F, Prajapati DP, Boone CE, DeConde AS. Association of chemosensory dysfunction and Covid-19 in patients presenting with influenza-like symptoms. Int Forum Allergy Rhinol 2020. https://doi.org/ 10.1002/alr.22579.
29- Bagheri SH, Asghari AM, Farhadi M, Shamshiri AR, Kabir A, Kamrava SK, et al. Coincidence of COVID-19 epidemic and olfactory dysfunction outbreak. medRxiv 2020.
30- Zhao Hua, Shen Dingding, Zhou Haiyan, Liu Jun, Chen Sheng. Guillain-Barré syndrome associated with SARS-CoV-2 infection: causality or coincidence?. Lancet Neurol 2020;19(5):383–4. https://doi.org/10.1016/S1474-4422(20) 30109-5.
31- Sedaghat Zahra, Karimi Narges. Guillain Barre syndrome associated with COVID-19 infection: a case report. J. Clin. Neurosci. 2020. https://doi.org/ 10.1016/j.jocn.2020.04.062.
32- Virani Ahmed, Rabold Erica, Hanson Taylor, Haag Aaron, Elrufay Rawiya, Cheema Tariq, Balaan Marvin, Bhanot Nitin. Guillain-Barré Syndrome associated with SARS-CoV-2 infection. IDCases 2020;20:e00771. https://doi. org/10.1016/j.idcr.2020.e00771.
33- Toscano G, Palmerini F, Ravaglia S, Ruiz L, Invernizzi P, Cuzzoni MG, Franciotta D, Baldanti F, Daturi R, Postorino P, Cavallini A, Micieli G. Guillain-Barré Syndrome Associated with SARS-CoV-2. N Engl J Med 2020. https://doi.org/ 10.1056/NEJMc2009191.
34- Radpour A, Bahrami-Motlagh H, Taaghi MT, Sedaghat A, Karimi MA, Hekmatnia A, Haghighatkhah HR, Sanei-Taheri M, Arab-Ahmadi M, Azhideh A. COVID-19 evaluation by low-dose High Resolution CT scans protocol. Academic radiology. 2020 Jun 1;27(6):901.
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36- Azhideh A. COVID-19 Neurological Manifestations. International Clinical Neuroscience Journal. 2020 Apr 1;7(2):54.
37- Firouzabadi MD, Firouzabadi FD, Goudarzi S, Jahandideh H, Roomiani M. Has the chief complaint of patients with COVID-19 disease changed over time?. Medical Hypotheses. 2020 Jun 7.
38- Firouzabadi FD, Firouzabadi MD, Ghalehbaghi B, Jahandideh H, Roomiani M, Goudarzi S. Have the symptoms of patients with COVID-19 changed over time during hospitalization?. Medical hypotheses. 2020 Jul 1.
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