Neurocognitive Dysfunction in Head Injured Patients, Does It Reveal Various Outcomes in Both Sexes and Age-Groups?
International Clinical Neuroscience Journal,
Vol. 5 No. 4 (2018),
20 December 2018
,
Page 121-125
Abstract
Background: Traumatic brain injury (TBI) is one of the main causes of death and disability in both sex, young and old age group population in different countries. This study aimed to estimate effects of sex, age group and intensity level of TBI in neurocognitive dysfunction.
Methods: The study was done using the mini-mental state examination (MMSE) to estimate cognitive dysfunction that directed presence to the emergency department center with medical cares in the Zahedan city. Individuals were deliberated eligible if they were 18 years of age or older. This investigation covered 6-months.
Results: The sample study estimated 85 patients, 73% males with 27% females. The mean age patients reported 32.5 years (range 18-66 year) and SD (12.924) with 95% CI. Two-way between groups analysis of variance test was used to assess the impacts of sex, age and level of TBI as measured by neurocognitive dysfunction. The interaction effect between sex, age group and level of TBI was statistically significant F (0, 85) = 3.96, P = 0.01 however, the effect size was medium (partial eta squared = 0.54).
Conclusion: This study supported research hypothesis that sex, age group and severity level of TBI show greater effect in neurocognitive dysfunction. In addition, the greatest amount of improvement in disability was observed among the male youngest group of survivors. These results advocate TBI survivors, especially older patients, may be candidates for neuroprotective therapies after TBI.
- Neurocognitive dysfunction
- Traumatic brain injury (TBI)
- Sex
- Age-group.
How to Cite
References
Barlow KM. Traumatic brain injury. Handb Clin Neurol. 2013;112:891-904. doi: 10.1016/B978-0-444-52910-7.00011-8.PubMed PMID:23622299.
Giza C. Traumatic brain injury. In book: International Neurology. 2016;pp.698-701.
Abou El Fadl M.H, O'Phelan K.H. Management of Traumatic Brain Injury. Neurol Clin. 2017;35(4):641-653. doi: 10.1016/j.ncl.2017.06.003. PubMed PMID: 28962805.
Turkstra L, Politis A.M. Traumatic Brain Injury. In book: Research in Clinical Pragmatics, 2017;pp.291-322.
Birkhead S. Post‐traumatic Brain Injury. In book: Occupational Therapy in Psychiatry and Mental Health, Fifth Edition. 2014;pp.356-367.
Wortzel HS, Arciniegas DB. Treatment of Post-Traumatic Cognitive Impairments. Curr Treat Options Neurol. 2012;14(5):493–508.PMCID: PMC3437653
Alemam AI, Mohamad HA, Alhadad AA. Memory and attention impairment after traumatic brain injury. Egyptian Journal of Neurology, Psychiatry and Neurosurgery. 2013;50(2):143-148.
Miotto EC, Cinalli FZ, Serrao VT, Benute GG, Lucia MC, Scaff M. Cognitive deficits in patients with mild to moderate traumatic brain injury. Arq Neuropsiquiatr. 2010;68(6):862-8.PubMed PMID: 21243242.
Gardner RC, Langa KM, Yaffe K. Subjective and objective cognitive function among older adults with a history of traumatic brain injury: A population-based cohort study. PLoS Medicine. 2017;14(3):e1002246.PubMed PMID: 28267747;PubMed Central PMCID: PMC5340352
Porter S, Torres IJ, Panenka W, Rajwani Z, Fawcett D, Hyder A, et al. Changes in brain-behavior relationships following a 3-month pilot cognitive intervention program for adults with traumatic brain injury. Heliyon. 2017; 3(8): e00373. doi: 10.1016/j.heliyon.2017.e00373. PubMed Central PMCID: PMC5545767.
Kinnunen KM, Greenwood R, Powell JH, Leech R, Hawkins PC, Bonnelle V, et al. White matter damage and cognitive impairment after traumatic brain injury. Brain. 2011;134(Pt 2):449-63. doi: 10.1093/brain/awq347. PubMed PMID: 21193486; PubMed Central PMCID: PMC3030764.
Stenberg M, Godbolt AK, Nygren De Boussard C, Levi R, Stålnacke BM. Cognitive Impairment after Severe Traumatic Brain Injury, Clinical Course and Impact on Outcome: A Swedish-Icelandic Study. Behavioural neurology 2015;(3):1-12.doi.org/10.1155/2015/680308.
Olsen A, Brunner JF, Indredavik Evensen KN, Finnanger TG, Vik A, Skandsen T, et al.Altered Cognitive Control Activations after Moderate-to-Severe Traumatic Brain Injury and Their Relationship to Injury Severity and Everyday-Life Function.Cereb Cortex. 2015; 25(8): 2170–2180.doi:10.1093/cercor/bhu023. PubMed PMID: 24557637; PubMed Central PMCID: PMC4494028.
Li W, Risacher SL, McAllister TW, Saykin AJ. Traumatic brain injury and age at onset of cognitive impairment in older adults. J Neurol. 2016 Jul;263(7):1280-5. doi: 10.1007/s00415-016-8093-4. PubMed PMID: 27007484; PubMed Central PMCID: PMC5029270
Bloom BM, Kinsella K, Pott J, Patel HC, Harris T, Lecky F, et al. Short-term neurocognitive and symptomatic outcomes following mild traumatic brain injury: A prospective multi-centre observational cohort study. Brain Inj. 2017;31(3):304-311. doi: 10.1080/02699052.2016.1256501. PubMed PMID: 28156140.
Traumatic brain injury [internet]. Arizona; Mayo Clinic. 2018- [cited 2018 January 17]. Available from: https://www.mayoclinic.org.
Vadikolias K, Tsiakiri-Vatamidis A, Tripsianis G, Tsivgoulis G, Ioannidis P, Serdari A, et al. Mild cognitive impairment: effect of education on the verbal and nonverbal tasks performance decline. Brain Behav. 2012; 2(5): 620–627.doi:10.1002/brb3.88. PubMed PMID: 23139907; PubMed Central PMCID:PMC3489814.
Miotto EC, Cinalli FZ, Serrao VT, Benute GG, Lucia MC, Scaff M. Cognitive deficits in patients with mild to moderate traumatic brain injury. Arq. Neuro-Psiquiatr. 2010;68(6). PubMed PMID: 21243242.
Wang ML, Li WB. Cognitive impairment after traumatic brain injury: The role of MRI and possible pathological basis. J Neurol Sci. 2016;15(370):244-250. doi: 10.1016/j.jns.2016.09.049. PubMed PMID: 27772768.
de Guise E, Leblanc J, Champoux MC, Couturier C, Alturki AY, Lamoureux J, et al. The mini-mental state examination and the Montreal Cognitive Assessment after traumatic brain injury: an early predictive study. Brain Inj. 2013;27(12):1428-34. doi: 10.3109/02699052.2013.835867. PubMed PMID: 24102622
Ansari NN, Naghdi S, Hasson S, Valizadeh L, Jalaie S. Validation of a Mini-Mental State Examination (MMSE) for the Persian Population: A Pilot Study. APPLIED NEUROPSYCHOLOGY. 2010;17:190–195.doi: 10.1080/09084282.2010.499773.PubMedPMID: 20799110.
de Guise E, Leblanc J, Champoux MC, Couturier C, Alturki AY, Lamoureux J, et al. The mini-mental state examination and the Montreal Cognitive Assessment after traumatic brain injury: an early predictive study. Brain Inj. 2013;27(12):1428-34. doi: 10.3109/02699052.2013.835867. PubMed PMID: 24102622
Willacy H. Mini Mental State Examination [Internet]. Lancaster: Lancaster University, Department: Lancaster Medical School;[updated 2017 febreuary 6]. Avalible from: https://patient.info/doctor/mini-mental-state-examination-mmse.
McInnes K, Friesen CL, MacKenzie DE, Westwood DA, Boe SG. Mild Traumatic Brain Injury (mTBI) and chronic cognitive impairment: A scoping review. PLoS One. 2017;12(4):e0174847. doi: 10.1371/journal.pone.0174847. PubMed PMID: 28399158; PubMed Central PMCID: PMC5388340.
Grossman EJ, Jensen JH, Babb JS, Chen Q, Tabesh A, Fieremans E, et al. Cognitive impairment in mild traumatic brain injury: a longitudinal diffusional kurtosis and perfusion imaging study. AJNR Am J Neuroradiol. 2013;34(5):951-7, S1-3. doi: 10.3174/ajnr.A3358. PubMed PMID: 23179649; PubMed Central PMCID: PMC3908903.
Finnanger TG, Skandsen T, Andersson S, Lydersen S, Vik A, Indredavik M. Differentiated patterns of cognitive impairment 12 months after severe and moderate traumatic brain injury. Brain Inj. 2013;27(13-14):1606-16. doi: 10.3109/02699052.2013.831127. PubMed PMID: 24102501.
Skandsen T, Finnanger TG, Andersson S, Lydersen S, Brunner JF, Vik A. Cognitive impairment 3 months after moderate and severe traumatic brain injury: a prospective follow-up study. Arch Phys Med Rehabil. 2010;91(12):1904-13. doi: 10.1016/j.apmr.2010.08.021. PubMed PMID: 21112433.
lawsuitlegal.com [Internet]. Florida: Soft Tissue Injuries Sustained In a Crash; c2015 [cited 2018 April 10]. Available from: http://lawsuitlegal.com/.
Ganti L, Daneshvar Y, Ayala S, Bodhit AN, Peters KR. The value of neurocognitive testing for acute outcomes after mild traumatic brain injury. Mil Med Res. 2016; 3: 23.doi: 10.1186/s40779-016-0091-4. PubMed Central PMCID: PMC4957408.
Muir SW, Gopaul K, Montero Odasso MM.The role of cognitive impairment in fall risk among older adults: a systematic review and meta-analysis.Age Ageing. 2012;41(3):299-308. doi: 10.1093/ageing/afs012. PubMed PMID: 22374645.
Wilson RS, Hebert LE, Scherr PA, Barnes LL, Mendes de Leon CF, Evans DA. Educational attainment and cognitive decline in old age. Neurology. 2009;72(5): 460–465.doi: 10.1212/01.wnl.0000341782.71418.6c. PubMed Central PMCID: PMC2677531.
Parisi JM, Rebok GW, Xue QL, Fried LP, Seeman TE, Tanner EK, et al. The Role of Education and Intellectual Activity on Cognition. Journal of Aging Research. 2012(1):416132. doi.org/10.1155/2012/416132.
Cadar D, Robitaille A, Clouston S, Hofer SM, Piccinin AM, Muniz-Terrera G. An International Evaluation of Cognitive Reserve and Memory Changes in Early Old Age in 10 European Countries. Neuroepidemiology. 2017;48(1-2):9-20. doi: 10.1159/000452276. PubMed PMID: 28219074; PubMed Central PMCID: PMC5472442.
Sumowski JF, Chiaravalloti N, Krch D, Paxton J, Deluca J. Education attenuates the negative impact of traumatic brain injury on cognitive status. Arch Phys Med Rehabil. 2013 Dec;94(12):2562-4. doi: 10.1016/j.apmr.2013.07.023. PubMed PMID: 23932968.
Schneider EB, Sur S, Raymont V, Duckworth J, Kowalski RG, Efron DT, et al. Functional recovery after moderate/severe traumatic brain injury. Neurology. 2014;82(18):1636-42. doi: 10.1212/WNL.0000000000000379. PubMed PMID: 24759845; PubMed Central PMCID: PMC4211893.
Cassels C. High Education Level May Reduce Memory Impairment, Delay Onset of Alzheimer's Symptoms. Neurology. 2008;71:1342-1349.
Olsen A. Cognitive Control Function and Moderate-to-Severe Traumatic Brain Injury: Functional and Structural Brain Correlates. [dissertation]. Circulation and Medical Imaging: Norwegian University; 2014.
sciencedaily.com [Internet]. Maryland: Higher education associated with better recovery from traumatic brain injury; c2014 [cited 2018April10]. Available from: http://www.sciencedaily.com/.
Garcia J, Sellers DM, Hilgendorf A, Burnett DL. Evaluation of a health education programme about traumatic brain injury. Health Education Journal 2014;73(5):588-599.
Barman A, Chatterjee A, Bhide R. Cognitive Impairment and Rehabilitation Strategies After Traumatic Brain Injury. Indian J Psychol Med. 2016;38(3): 172–181.doi: 10.4103/0253-7176.183086. PubMed Central PMCID: PMC4904751.
- Abstract Viewed: 398 times
- PDF Downloaded: 303 times