International Clinical Neuroscience Journal

Vol. 3 No. 3 (2016)

MRI Findings of Primary CNS Lymphoma in 20 Patients of Stereotaxic Ward

International Clinical Neuroscience Journal, Vol. 3 No. 3 (2016), 7 December 2016 , Page 158-163
https://doi.org/10.22037/icnj.v3i3.14422

Abstract

PURPOSE: To record the MRI features of primary central nervous system lymphoma (PCNSL) and compare these properties in monofocal and multifocal disease.

METHODS: Eleven cases of monofocal disease were compared to 9 cases of multifocal disease. All patients were examined by non-enhanced and contrast-enhanced MRI. Tumor location, signal intensity, enhancement characteristics, age distribution, peritumoral edema, cystic changes, and the presence of calcifications were assessed. The MRI features were compared between the monofocal and multifocal patients.

RESULTS: There were 20 cases including both the monofocal and multifocal cases. Contrast-enhanced images showed variable enhancement patterns: homogeneous enhancement (14 patients), and hetrogenous enhancement (6 patients). One case of hemorrhage and two cases of cystic formation were observed. Intra-tumoral calcification was not detected. The frontal lobe, the corpus callosum and the basal ganglia were commonly involved in both the monofocal and multifocal lesion.

CONCLUSION: Our data showed that PCNSL has a variable enhancement and edema pattern on MRI. Monofocal PCNSL cases typically have larger size tumors with mild or marked enhancement.

Keywords:
  • Brain neoplasm
  • Lymphoma
  • Magnetic resonance (MR)
  • Computed tomography (CT)

How to Cite

1.
Fazeli MA, Janamiri Z, Zali A, Seddighi A, Seddighi A, Ashrafi F, Asadi N. MRI Findings of Primary CNS Lymphoma in 20 Patients of Stereotaxic Ward. Int Clin Neurosci J [Internet]. 2016 Dec. 7 [cited 2023 Nov. 29];3(3):158-63. Available from: https://journals.sbmu.ac.ir/neuroscience/article/view/14422

References

Gutmann J, Kendall B. Unusual appearances of primary central nervous system non-Hodgkin's lymphoma. ClinRadiol. 1994;49:696–702.

Watanabe M, Tanaka R, Takeda N, Wakabayashi K, Takahashi H. Correlation of computed tomography with the histopathology of primary malignant lymphoma of the brain. Neuroradiology. 1992;34:36–42.

Coulon A, Lafitte F, Hoang-Xuan K, Martin-Duverneuil N, Mokhtari K, Blustajn J, et al. Radiographic findings in 37 cases of primary CNS lymphoma in immunocompetent patients. EurRadiol. 2002;12:329–340.

Miller DC, Hochberg FH, Harris NL, Gruber ML, Louis DN, Cohen H. Pathology with clinical correlations of primary central nervous system non-Hodgkin's lymphoma. The Massachusetts General Hospital experience 1958-1989. Cancer. 1994;74:1383–1397.

Nitta T, Uda K, Ebato M, Ikezaki K, Fukui M, Sato K. Primary peripheral-postthymic T-cell lymphoma in the central nervous system: immunological and molecular approaches to diagnosis. J Neurosurg. 1995;82:77–82.

Slone HW, Blake JJ, Shah R, Guttikonda S, Bourekas EC. CT and MRI findings of intracranial lymphoma. AJR Am J Roentgenol. 2005;184:1679–1685. 7. Jack CR, Jr, Reese DF, Scheithauer BW. Radiographic findings in 32 cases of primary CNS lymphoma. AJR Am J Roentgenol. 1986;146:271–276.

Jack CR, Jr, O'Neill BP, Banks PM, Reese DF. Central nervous system lymphoma: histologic types and CT appearance. Radiology. 1988;167:211–215.

Johnson BA, Fram EK, Johnson PC, Jacobowitz R. The variable MR appearance of primary lymphoma of the central nervous system: comparison with histopathologic features. AJNR Am J Neuroradiol. 1997;18:563–572.

Küker W, Nägele T, Korfel A, Heckl S, Thiel E, Bamberg M, et al. Primary central nervous system lymphomas (PCNSL): MRI features at presentation in 100 patients. J Neurooncol. 2005;72:169–177.

Jenkins CN, Colquhoun IR. Characterization of primary intracranial lymphoma by computed tomography: an analysis of 36 cases and a review of the literature with particular reference to calcification haemorrhage and cyst formation. ClinRadiol. 1998;53:428–434.

Onda K, Wakabayashi K, Tanaka R, Takahashi H. Intracranial malignant lymphomas: clinicopathological study of 26 autopsy cases. Brain Tumor Pathol. 1999;16:29–35.

Bataille B, Page P. Prognostic factors and primary cerebral lymphoma. Neurochirurgie. 1997;43:385–387. [French]

Dubuisson A, Kaschten B, Lénelle J, Martin D, Robe P, Fassotte MF, et al. Primary central nervous system lymphoma report of 32 cases and review of the literature. ClinNeurolNeurosurg. 2004;107:55–63.

Herrlinger U, Schabet M, Bitzer M, Petersen D, Krauseneck P. Primary central nervous system lymphoma: from clinical presentation to diagnosis. J Neurooncol. 1999;43:219–226.

Erdag N, Bhorade RM, Alberico RA, Yousuf N, Patel MR. Primary lymphoma of the central nervous system: typical and atypical CT and MR imaging appearances. AJR Am J Roentgenol. 2001;176:1319–1326.

Gliemroth J, Kehler U, Gaebel C, Arnold H, Missler U. Neuroradiological findings in primary cerebral lymphomas of non-AIDS patients. ClinNeurolNeurosurg. 2003;105:78–86.

Cellerier P, Chiras J, Gray F, Metzger J, Bories J. Computed tomography in primary lymphoma of the brain. Neuroradiology. 1984;26:485–492.

Hochberg FH, Miller DC. Primary central nervous system lymphoma. J Neurosurg. 1988;68:835–853.

Holodny AI, Nusbaum AO, Festa S, Pronin IN, Lee HJ, Kalnin AJ. Correlation between the degree of contrast enhancement and the volume of peritumoral edema in meningiomas and malignant gliomas. Neuroradiology. 1999;41:820–825.

Koeller KK, Smirniotopoulos JG, Jones RV. Primary central nervous system lymphoma: radiologic-pathologic correlation. Radiographics. 1997;17:1497–1526.

Brown JH, Stallmeyer MJ, Lustrin ES, Chew FS. Primary cerebral lymphoma. AJR Am J Roentgenol. 1995;165:626.

Reni M, Ferreri AJ, Garancini MP, Villa E. Therapeutic management of primary central nervous system lymphoma in immunocompetent patients: results of a critical review of the literature. Ann Oncol. 1997;8:227–234.

Schabet M. Epidemiology of primary CNS lymphoma. J Neurooncol. 1999;43:199–201.

Jiddane M, Nicoli F, Diaz P, Bergvall U, Vincentelli F, Hassoun J, et al. Intracranial malignant lymphoma. Report of 30 cases and review of the literature. J Neurosurg. 1986;65:592–599.

Thomas M, MacPherson P. Computed tomography of intracranial lymphoma. ClinRadiol. 1982;33:331–336.

DeAngelis LM. Cerebral lymphoma presenting as a nonenhancing lesion on computed tomographic/magnetic resonance scan. Ann Neurol. 1993;33:308–311.

Terae S, Ogata A. Nonenhancing primary central nervous system lymphoma. Neuroradiology. 1996;38:34–37.

Braks E, Urbach H, Pels H, Träber F, Block W, Schild HH. Primary central nervous system immunocytoma: MRI and spectroscopy. Neuroradiology. 2000;42:738–741.

Masdeu JC, Quinto C, Olivera C, Tenner M, Leslie D, Visintainer P. Open-ring imaging sign: highly specific for atypical brain demyelination. Neurology. 2000;54:1427–1433.

Bizzi A, Movsas B, Tedeschi G, Phillips CL, Okunieff P, Alger JR, et al. Response of non-Hodgkin lymphoma to radiation therapy: early and long-term assessment with H-1 MR spectroscopic imaging. Radiology. 1995;194:271–276.

  • Abstract Viewed: 330 times
  • PDF Downloaded: 272 times

Download Statastics