The Issue of Embryo Implantation in Women during the Coronavirus Outbreak: An Overview Embryo Implantation and Coronavirus
Novelty in Biomedicine,
Vol. 9 No. 3 (2021),
13 August 2021
,
Page 138-144
https://doi.org/10.22037/nbm.v9i3.33988
Abstract
Abstract
The Coronavirus is a major health problem nowadays, which affects people's lifestyle. This pandemic virus shared a variety of phenomena in case of symptoms and side effects. One of the major issues regarding novel coronavirus is the effect of infection on pregnancy which accounts for an essential process of human life. Considering the pathogenesis of Coronavirus, overexpression of inflammatory cells and cytokines accounts a pivotal step in the development of symptoms. The over-expressed cytokines in response to covid-19 infection would render the inflammation and disruption of the immune system and tissue damage. Like coronavirus infection, implantation the main step of a successful pregnancy, activates the inflammatory cells and cytokines. The association of infection with pregnancy raises the concern about the effect of covid-19 on embryos and giving normal birth, especially in women who decide to get pregnant or are in the pregnancy period. The current review focused on immune system responses to the Coronavirus and comparison with immune system activation during implantation. It concluded that further laboratory research and studies are needed to better understand and draw general conclusions about the role of the virus in embryo implantation.
- Coronavirus, Implantation, Embryo, Immune response
How to Cite
References
Abrahams VM, Kim YM, Straszewski SL, et al. Macrophages and Apoptotic Cell Clearance During Pregnancy. Am J Reprod Immunol. 2004;51:275-82.
Adhikari SP, Meng S, Wu Y-J, et al. Epidemiology, Causes, Clinical Manifestation and Diagnosis, Prevention and Control of Coronavirus Disease (Covid-19) During the Early Outbreak Period: A Scoping Review. Infect Dis Poverty. 2020;9:1-12.
Akira S, Yoshida K, Tanaka T, et al. Targeted Disruption of the Il‐6 Related Genes: Gp130 and Nf‐Il‐6. Immunol Rev. 1995;148: 221-53.
Ank N, West H, Bartholdy C, et al. Lambda Interferon (Ifn-Λ), a Type Iii Ifn, Is Induced by Viruses and Ifns and Displays Potent Antiviral Activity against Select Virus Infections in Vivo. J virol. 2006;80:4501-09.
Carson DD, Bagchi I, Dey SK, et al. Embryo Implantation. Dev biol. 2000;223:217-37.
Cha J, Sun X, Dey SK. Mechanisms of Implantation: Strategies for Successful Pregnancy. Nat med. 2012;18:1754-67.
Chan YK, Gack MU. Rig-I-Like Receptor Regulation in Virus Infection and Immunity. Curr Opin. 2015;12:7-14.
Chappel SC, Howles C. Reevaluation of the Roles of Luteinizing Hormone and Follicle-Stimulating Hormone in the Ovulatory Process. Hum Reprod. 1991;6:1206-12.
Cheng J-G, Rodriguez CI, Stewart CL. Control of Uterine Receptivity and Embryo Implantation by Steroid Hormone Regulation of Lif Production and Lif Receptor Activity: Towards a Molecular Understanding of "the Window of Implantation". Rev Endocr Metab Disord. 2002;3:119-26.
Conti P, Ronconi G, Caraffa A, et al. Induction of Pro-Inflammatory Cytokines (Il-1 and Il-6) and Lung Inflammation by Coronavirus-19 (Covi-19 or Sars-Cov-2): Anti-Inflammatory Strategies. J Biol Regul Homeost. 2020;34, 1.
Cook DN, Beck MA, Coffman TM, et al. Requirement of Mip-1 Alpha for an Inflammatory Response to Viral Infection. Science. 1995;269:1583-85.
Costela-Ruiz VJ, Illescas-Montes R, Puerta-Puerta JM, et al. Sars-Cov-2 Infection: The Role of Cytokines in Covid-19 Disease. Cytokine Growth Factor Rev. 2020;54:62–75.
Dostert C, Jouanguy E, Irving P, et al. The Jak-Stat Signaling Pathway Is Required but Not Sufficient for the Antiviral Response of Drosophila. Nat Immunol. 2005;6:946-53.
Edelmann KH, Richardson-Burns S, Alexopoulou L, et al. Does Toll-Like Receptor 3 Play a Biological Role in Virus Infections?. Virol J. 2004;322:231-38.
Everett H, Mcfadden G. Apoptosis: An Innate Immune Response to Virus Infection. Trends Microbiol. 1999;7:160-65.
Faas MM, Spaans F, De Vos P. Monocytes and Macrophages in Pregnancy and Pre-Eclampsia. Front Immunol. 2014;5:298.
Haga S, Yamamoto N, Nakai-Murakami C, et al. Modulation of Tnf-Α-Converting Enzyme by the Spike Protein of Sars-Cov and Ace2 Induces Tnf-Α Production and Facilitates Viral Entry. Proc Natl Acad Sci U S A. 2008;105:7809-14.
Hernandez ER. Embryo Implantation and Gnrh Antagonists: Embryo Implantation: The Rubicon for Gnrh Antagonists. Hum Reprod. 2000;15:1211-16.
Hilton D. Negative Regulators of Cytokine Signal Transduction. Cell Mol Life Sci. 1999;55:1568-77.
Jensen S, Thomsen AR. Sensing of Rna Viruses: A Review of Innate Immune Receptors Involved in Recognizing Rna Virus Invasion. J virol. 2012;86:2900-10.
Koga K, Mor G. Expression and Function of Toll-Like Receptors at the Maternal—Fetal Interface. Reprod Sci. 2008;15:231-42.
Large MJ, Demayo FJ. The Regulation of Embryo Implantation and Endometrial Decidualization by Progesterone Receptor Signaling. Mol Cell Endocrinol. 2012;358:155-65.
Laskarin G, Kämmerer U, Rukavina D, et al. Antigen‐Presenting Cells and Materno‐Fetal Tolerance: An Emerging Role for Dendritic Cells. Am J Reprod Immunol. 2007;58:255-67.
Lauxmann MA, Santucci NE, Autrán-Gómez AM. The Sars-Cov-2 Coronavirus and the Covid-19 Outbreak. Int Braz J Urol. 2020;46:6-18.
Le Bouteiller P, Piccinni MP. Human Nk Cells in Pregnant Uterus: Why There?. Am J Reprod Immunol. 2008;59:401-06.
Li G, Fan Y, Lai Y, et al. Coronavirus Infections and Immune Responses. J Med Virol. 2020;92:424-32.
Liu H, Wang L-L, Zhao S-J, et al. Why Are Pregnant Women Susceptible to Covid-19? An Immunological Viewpoint. J of reprod Immunol. 2020;139:103122.
Lupfer C, Kanneganti TD. The Expanding Role of Nlr S in Antiviral Immunity. Immunol Rev. 2013;255:13-24.
Luster AD, Alon R, Von Andrian UH. Immune Cell Migration in Inflammation: Present and Future Therapeutic Targets. Nat Immunol. 2005;6:1182-90.
Mccarty MF, Dinicolantonio JJ. Nutraceuticals Have Potential for Boosting the Type 1 Interferon Response to Rna Viruses Including Influenza and Coronavirus. Prog Cardiovasc Dis. 2020.
Miller S, Krijnse-Locker J. Modification of Intracellular Membrane Structures for Virus Replication. Nature Reviews Microbiology. 2008;6:363-74.
Mohammadi MT, Shahyad S. Health Anxiety During Viral Contagious Diseases and Covid-19 Outbreak: Narrative Review. J Mil Med. 2020;22:623-31.
Mor G. Inflammation and Pregnancy: The Role of Toll‐Like Receptors in Trophoblast–Immune Interaction. Ann N Y Acad Sci. 2008;1127:121-28.
Mor G, Cardenas I, Abrahams V, et al. Inflammation and Pregnancy: The Role of the Immune System at the Implantation Site. Ann N Y Acad Sci. 2011;1221:80.
Naka T, Narazaki M, Hirata M, et al. Structure and Function of a New Stat-Induced Stat Inhibitor. Nature. 1997;387: 924-29.
Nelemans T, Kikkert M. Viral Innate Immune Evasion and the Pathogenesis of Emerging Rna Virus Infections. Viruses. 2019;11:961.
Nicola NA, Babon JJ. Leukemia Inhibitory Factor (Lif). Cytokine Growth Factor Rev. 2015;26:533-44.
Payne S. Introduction to Rna Viruses. Viruses 2017, 97.
Plaks V, Birnberg T, Berkutzki T, et al. Uterine Dcs Are Crucial for Decidua Formation During Embryo Implantation in Mice. J Clin Invest. 2008;118:3954-65.
Rabbani M, Rogers P. Role of Vascular Endothelial Growth Factor in Endometrial Vascular Events before Implantation in Rats. Reproduction. 2001;122:85.
Racicot K, Mor G. Risks Associated with Viral Infections During Pregnancy. J clin invest. 2017;127:1591-99.
Rezaee D, Bandehpour M, Kazemi B, et al. Role of Intrauterine Administration of Transfected Peripheral Blood Mononuclear Cells by Gm-Csf on Embryo Implantation and Pregnancy Rate in Mice. Mol Hum Reprod. 2020;26:101-10.
Romero-Brey I, Bartenschlager R. Membranous Replication Factories Induced by Plus-Strand Rna Viruses. Viruses. 2014;6:2826-57.
Roussev RG, Acacio B, Ng SC, et al. Duration of Intralipid's Suppressive Effect on Nk Cell's Functional Activity. Am J Reprod Immunol. 2008;60:258-63.
Salleh N, Giribabu N. Leukemia Inhibitory Factor: Roles in Embryo Implantation and in Nonhormonal Contraception. Sci World J. 2014;2014.
Schoggins JW. Interferon-Stimulated Genes: Roles in Viral Pathogenesis. Curr Opin Virol. 2014;6:40-6.
Scutigliani EM, Kikkert M. Interaction of the Innate Immune System with Positive-Strand Rna Virus Replication Organelles. Cytokine Growth Factor Rev. 2017;37:17-27.
Silverman RH, Weiss SR. Viral Phosphodiesterases That Antagonize Double-Stranded Rna Signaling to Rnase L by Degrading 2-5a. J Interferon Cytokine Res. 2014;34:455-63.
Suman P, Malhotra SS, Gupta SK. Lif-Stat Signaling and Trophoblast Biology. Jak-stat. 2013;2:e25155.
Thompson AJ, Locarnini SA. Toll‐Like Receptors, Rig‐I‐Like Rna Helicases and the Antiviral Innate Immune Response. Immunol Cell Biol. 2007;85:435-45.
Von Andrian UH, Mempel TR. Homing and Cellular Traffic in Lymph Nodes. Nat Rev Immunol. 2003;3:867-78.
Wang W, Ye L, Ye L, et al. Up-Regulation of Il-6 and Tnf-Α Induced by Sars-Coronavirus Spike Protein in Murine Macrophages Via Nf-Κb Pathway. Virus Res. 2007;128:1-8.
Wang Y, Shi H, Rigolet P, et al. Nsp1 Proteins of Group I and Sars Coronaviruses Share Structural and Functional Similarities. Infect Genet Evol. 2010;10:919-24.
Ware CB, Horowitz MC, Renshaw BR, et al. Targeted Disruption of the Low-Affinity Leukemia Inhibitory Factor Receptor Gene Causes Placental, Skeletal, Neural and Metabolic Defects and Results in Perinatal Death. Development. 1995;121:1283-99.
Weatherbee BA, Glover DM, Zernicka-Goetz M. Expression of Sars-Cov-2 Receptor Ace2 and the Protease Tmprss2 Suggests Susceptibility of the Human Embryo in the First Trimester. Open Biol. 2020;10:200162.
Wilczyński JR. Th1/Th2 Cytokines Balance—Yin and Yang of Reproductive Immunology. Eur J Obstet Gynecol Reprod Biol. 2005;122:136-43.
Wong SF, Chow KM, Leung TN, et al. Pregnancy and Perinatal Outcomes of Women with Severe Acute Respiratory Syndrome. Am J Obstet Gynecol. 2004;191:292-97.
Yoshinaga K, 'Review of Factors Essential for Blastocyst Implantation for Their Modulating Effects on the Maternal Immune System'. Semin Cell Dev Biol. 2008;19(2):161-9.
Zhang J, Wang L, Cai L, et al. The Expression and Function of Vegf at Embryo Implantation "Window" in the Mouse. Sci Bull. 2001;46:409-11.
Zhang Y, Guo Y, Lv K, et al. Molecular Cloning and Functional Characterization of Porcine Toll-Like Receptor 7 Involved in Recognition of Single-Stranded Rna Virus/Ssrna. Mol Immunol. 2008;45:1184-90.
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