Olfactory and Gustatory Dysfunctions as Prognostic Factors in Patients with the SARS-CoV-2 Virus COVID-19 and olfactory and gustatory dysfunction
Journal of Cellular & Molecular Anesthesia,
Vol. 7 No. 4 (2022),
11 Shahrivar 2022
,
Page 213-219
https://doi.org/10.22037/jcma.v7i3.38157
Abstract
Background: COVID-19 neurologic symptoms such as anosmia and ageusia are considered the most challenging issues for patients in the first steps of viral infection. Herein, we aimed to investigate the olfactory and gustatory dysfunction and their association with prognostic factors in patients with COVID-19.
Materials and Methods: The current retrospective study was performed on patients admitted to a hospital with a definite diagnosis of COVID-19 between March and November 2020. Based on the study criteria, information of 150 eligible participants (89 males and 61 females) was completely collected. The olfactory and gustatory symptoms including anosmia, hyposmia, ageusia, and dysgeusia were assessed, and five main COVID-19 prognostic factors including level of D-dimer, C-reactive protein (CRP), lymphocyte count (LC), lactic acid dehydrogenase (LDH) and COVID-19 related lung involvement were measured.
Results: Among all patients, 102 (68%) participants were completely treated and 48 (32%) died. Compared to treated patients, all prognostic factors including CRP, LDH, LC, D-dimer, and lung involvement were significantly higher in death cases. We found that 97 (64.7%) patients experienced at least one olfactory or gustatory dysfunction. The level of CRP, LC, D-dimer, and lung involvement showed a better prognosis among patients with at least one sensory dysfunction. Moreover, a better outcome was observed in patients with sensory dysfunction.
Conclusion: It can be concluded the evaluation of CRP, LDH, D-dimer, and LC together with the HRCT scan score contributes to a better prognosis in COVID-19 patients with sensory dysfunction.
- COVID-19, Prognosis, Olfactory, gustatory dysfunction, HRCT
How to Cite
References
Rajaei S, Dabbagh A. The immunologic basis of COVID-19: a clinical approach. J Cell Mol Anesth. 2020;5(1):37-42.
Bedford J, Enria D, Giesecke J, Heymann DL, Ihekweazu C, Kobinger G, et al. COVID-19: towards controlling of a pandemic. Lancet. 2020;395(10229):1015-8.
Chary E, Carsuzaa F, Trijolet JP, Capitaine AL, Roncato-Saberan M, Fouet K, et al. Prevalence and Recovery From Olfactory and Gustatory Dysfunctions in Covid-19 Infection: A Prospective Multicenter Study. Am J Rhinol Allergy. 2020;34(5):686-93.
Zhou F, Yu T, Du R, Fan G, Liu Y, Liu Z, et al. Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study. Lancet. 2020;395(10229):1054-62.
Mehraeen E, Behnezhad F, Salehi MA, Noori T, Harandi H, SeyedAlinaghi S. Olfactory and gustatory dysfunctions due to the coronavirus disease (COVID-19): a review of current evidence. Eur Arch Otorhinolaryngol. 2021;278(2):307-12.
Nakashima T, Suzuki H, Teranishi M. Olfactory and gustatory dysfunction caused by SARS-CoV-2: Comparison with cases of infection with influenza and other viruses. Infect Control Hosp Epidemiol. 2021;42(1):113-4.
Hajikhani B, Calcagno T, Nasiri MJ, Jamshidi P, Dadashi M, Goudarzi M, et al. Olfactory and gustatory dysfunction in COVID-19 patients: A meta-analysis study. Physiol Rep. 2020;8(18):e14578.
Terpos E, Ntanasis-Stathopoulos I, Elalamy I, Kastritis E, Sergentanis TN, Politou M, et al. Hematological findings and complications of COVID-19. Am J Hematol. 2020;95(7):834-47.
Faghihi Langroudi T, Khazaei M. Common imaging patterns of COVID-19 on spiral chest CT scan: a diagnostic approach for pulmonary involvement in ICU patients. J Cell Mol Anesth. 2020;5(1):6-15.
Liu J, Tu C, Zhu M, Wang J, Yang C, Liu W, et al. The clinical course and prognostic factors of severe COVID-19 in Wuhan, China: A retrospective case-control study. Medicine (Baltimore). 2021;100(8):e23996.
Hong LZ, Shou ZX, Zheng DM, Jin X. The most important biomarker associated with coagulation and inflammation among COVID-19 patients. Mol Cell Biochem. 2021;476(7):2877-85.
Alamdari NM, Afaghi S, Rahimi FS, Tarki FE, Tavana S, Zali A, et al. Mortality Risk Factors among Hospitalized COVID-19 Patients in a Major Referral Center in Iran. Tohoku J Exp Med. 2020;252(1):73-84.
Chang CC, Yang MH, Chang SM, Hsieh YJ, Lee CH, Chen YA, et al. Clinical significance of olfactory dysfunction in patients of COVID-19. J Chin Med Assoc. 2021;84(7):682-9.
Hoang MP, Kanjanaumporn J, Aeumjaturapat S, Chusakul S, Seresirikachorn K, Snidvongs K. Olfactory and gustatory dysfunctions in COVID-19 patients: A systematic review and meta-analysis. Asian Pac J Allergy Immunol. 2020;38(3):162-9.
Luers JC, Rokohl AC, Loreck N, Wawer Matos PA, Augustin M, Dewald F, et al. Olfactory and Gustatory Dysfunction in Coronavirus Disease 2019 (COVID-19). Clin Infect Dis. 2020;71(16):2262-4.
Gane SB, Kelly C, Hopkins C. Isolated sudden onset anosmia in COVID-19 infection. A novel syndrome? Rhinology. 2020;58(3):299-301.
Moein ST, Hashemian SM, Mansourafshar B, Khorram-Tousi A, Tabarsi P, Doty RL. Smell dysfunction: a biomarker for COVID-19. Int Forum Allergy Rhinol. 2020;10(8):944-50.
Porta-Etessam J, Núñez-Gil IJ, González García N, Fernandez-Perez C, Viana-Llamas MC, Eid CM, et al. COVID-19 anosmia and gustatory symptoms as a prognosis factor: a subanalysis of the HOPE COVID-19 (Health Outcome Predictive Evaluation for COVID-19) registry. Infection. 2021;49(4):677-84.
Talavera B, García-Azorín D, Martínez-Pías E, Trigo J, Hernández-Pérez I, Valle-Peñacoba G, et al. Anosmia is associated with lower in-hospital mortality in COVID-19. J Neurol Sci. 2020;419:117163.
Sanli DET, Altundag A, Kandemirli SG, Yildirim D, Sanli AN, Saatci O, et al. Relationship between disease severity and serum IL-6 levels in COVID-19 anosmia. Am J Otolaryngol. 2021;42(1):102796.
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