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  3. Vol. 5 No. 3 (2020): July 2020
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ISSN: 2538-2462

July 2020
Vol. 5 No. 3 (2020)

Fibrinogen and Fibrin Degradation Products’ Levels in Cardiopulmonary Bypass with Mild-Hypothermia versus Normothermia

  • Bahram Ghasemzade
  • Motahare Ghodrati
  • Naser Kachuian
  • Yadollah Banakar
  • Farhad Gorjipour
  • Ali Asghar Zarei
  • Hosein Zaree

Journal of Cellular & Molecular Anesthesia, Vol. 5 No. 3 (2020), , Page 157-163
https://doi.org/10.22037/jcma.v5i3.30324 Published 15 May 2020

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Abstract

Background: Coagulation cascades are activated during Cardiopulmonary Bypass (CPB) and their proper monitoring and maintenance determine the outcomes of operation to a big extent. Here, we assessed serum fibrinogen and Fibrin Degradation Products (FDP) in adult patients undergoing CABG with using CPB, either with hypothermia or normothermia.
Materials and Methods: In a cross-sectional study, 80 adult patients’ candidate for elective CABG were randomly assigned into two groups: hypothermia and normothermia to assess fibrinogen and FDP, perioperatively.
Results: Patients included 32 men (80%) in the hypothermia group and 26 men (60%) in the normothermia with the mean age of 61.43 ± 12.64 years. The mean temperature in the hypothermia group was 32.33 ± 1.44 and 35.33 ± 0.71 in the normothermic group. Differences in fibrinogen levels between the two groups were not significant (Fib before CPB, P=0.893, and Fib after declamping, P=0.057). The serum level of FDP before and during CPB was not significantly different in hypothermia and normothermia groups (P=0.412, P=0.778, respectively).
Conclusion: During cardiac surgery in hypothermia and normothermia conditions rate of fibrinogen decreased 25% after declamping in each group; this decrease seems to be due to hemodilution. FDP levels were similar in both groups.
Keywords:
  • fibrinogen
  • fibrin degradation products (FDPs)
  • Hypothermia
  • cardiopulmonary bypass
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How to Cite

1.
Ghasemzade B, Ghodrati M, Kachuian N, Banakar Y, Gorjipour F, Zarei AA, Zaree H. Fibrinogen and Fibrin Degradation Products’ Levels in Cardiopulmonary Bypass with Mild-Hypothermia versus Normothermia. J Cell Mol Anesth [Internet]. 2020May15 [cited 2023Jun.6];5(3):157-63. Available from: https://journals.sbmu.ac.ir/jcma/article/view/30324
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