Coagulation Factor XIII-A A614T gene Variation is Suggestive of Founder Effect in Iranian Patients with Severe Congenital Factor XIII Deficiency
Journal of Cellular & Molecular Anesthesia,
Vol. 1 No. 1 (2016),
21 December 2015
,
Page 19-22
https://doi.org/10.22037/jcma.v1i1.10638
Abstract
Background: Factor XIII (FXIII) is a heterotetramer consisting of two subunits, FXIII-A and FXIII-B. Several common gene variations were observed in the FXIII-A gene with an obvious ethnic difference. This study assessed the prevalence of A614T as a common FXIII-A gene variation among Iranian patients with FXIII deficiency (FXIIID). Materials and Methods: This study was conducted on eighty Iranian unrelated individuals with FXIIID. Genotype analysis for FXIII-A A614T gene variation was performed for all individuals. Results: Molecular analysis of these Iranian populations revealed that all studied patients were homozygous for the T allele at codon 204 of the FXIII-A1 subunit. Conclusion: Present of T allele at codon 204 of FXIII-A1 subunit among all study population can be suggestive of founder effect.
- Coagulation Factor
- XIII-A A614T gene
- Congenital
- Factor XIII Deficiency
- Factor XIII
- Polymorphism
- Mutation
How to Cite
References
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