Aldosterone and renin-early and easy to measure prognostic biomarkers in serum and urine in posterior urethral valve. Prognostic marker in PUV
Iranian Journal of Pediatric Surgery,
Vol. 10 No. 2 (2024),
30 October 2024
,
Page 169-178
https://doi.org/10.22037/irjps.v10i2.44954
Abstract
Introduction: Posterior urethral valve (PUV) is one of the most common causes of obstructive uropathy in the children. Approximately one -third of such children end in chronic kidney disease (CKD) in future despite good management. There are some clinical parameters that are assumed poor renal outcome indicators.Many novel biomarkers are coming in limelight for early detection of chronic kidney disease. Increase of renin and aldosterone values in serum and urine as a result of tubulointerstitial damage can be marked as an early biomarker for prognosis.Therefore, this study focuses to assess the role of urinary and serum aldosterone and renin values in PUV patients before and after valve ablation.
Materials and Methods: This is a prospective observational study. It was conducted from September 2020 to August 2022 in the Department of pediatric surgery. The study group included 20 male babies with confirmed diagnosis of PUV. Clinical and radiological parameters were assessed. Plasma renin and aldosterone were measured using sandwich enzyme-linked Immunosorbent assay (ELISA) (ELK Biotechnology Co. LTD., Hubei, P.R.C.). Briefly, plasma samples or standard concentrations of the biomarker of interest were incubated in different 96-well ELISA plates coated with the appropriate antibodies. Statistical analyses were performed in Microsoft (MS) Excel using two-tailed Student’s t-test. The Pearson test was used for correlation.
Results: Mean age of PUV patients was 2.72 years, whilst in the control group it was 2.58 years. Deranged renal function like raised urea and creatinine were significantly higher in the patient group than the control group. Median renin (82.89pg/ml) and aldosterone (71.76 pg./ml) in the patients with cases were significantly higher than the age-matched control group. In each age group, all levels of renin and aldosterone in urine and serum level were higher among patients than control. Levels of aldosterone level and renin correlated positively with serum and urea creatinine at presentation and follow-up.
Conclusion: Prognostic biomarkers are needed for PUV patients. Aldosterone and renin can be considered as early prognostic marker which are easy to measure in serum and urine.
- Posterior urethral valve
- Chronic Kidney disease
- Creatinine
- Biomarkers
- Aldosterone
- Renin
How to Cite
References
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