The effect of special training exercise on FGF21 expression and FGFR-1 among CABG patients
Researcher Bulletin of Medical Sciences,
Vol. 26 No. 1 (2021),
30 Aban 2021
Background: The aim of this study is to evalute special training exercise on the FGF21 and FGFR-1 among coronary artery bypass surgery (CABG) patients.
Materials and Methods: The study method was semi-experimental and the statistical population was patients who had heart disease, after coronary artery bypass surgery.
Results: The study results showed 8 weeks of special exercises among the experimental group had a significant increase in the expression levels of FGF21 and FGFR1 among CABG patients, compared to the control group. Physical activity may increase FGF21 levels, which is an important factor in oxidative stress and inflammation.
Conclusion: The study results showed 8 weeks of special exercises among the experimental group had a significant increase in the expression levels of FGF21 and FGFR1 among CABG patients, compared to the control group. Physical activity may increase FGF21 levels, which is an important factor in oxidative stress and inflammation.
- Special training exercise; FGF21; FGFR-1; CABG patients
How to Cite
2. Friedl, R., et al., Intimal hyperplasia and expression of transforming growth factor-β1 in saphenous veins and internal mammary arteries before coronary artery surgery. The Annals of thoracic surgery, 2004. 78(4): p. 1312-1318.
3. Schoknecht, K., Y. David, and U. Heinemann. The blood–brain barrier—gatekeeper to neuronal homeostasis: clinical implications in the setting of stroke. in Seminars in cell & developmental biology. 2015. Elsevier.
4. Zhang, J., et al., The role of FGF21 in type 1 diabetes and its complications. International Journal of Biological Sciences, 2018. 14(9): p. 1000.
5. Brewer, J.R., P. Mazot, and P. Soriano, Genetic insights into the mechanisms of Fgf signaling. Genes & development, 2016. 30(7): p. 751-771.
6. Denizot, Y., et al., Alterations in plasma angiogenic growth factor concentrations after coronary artery bypass graft surgery: relationships with post-operative complications. Cytokine, 2003. 24(1-2): p. 7-12.
7. Sellke, F.W. and M. Ruel, Vascular growth factors and angiogenesis in cardiac surgery. The Annals of thoracic surgery, 2003. 75(2): p. S685-S690.
8. Medicine, A.C.o.S., Guidelines for graded exercise testing and exercise prescription. 1980: Lea & Febiger.
9. Sumide, T., et al., Relationship between exercise tolerance and muscle strength following cardiac rehabilitation: comparison of patients after cardiac surgery and patients with myocardial infarction. Journal of Cardiology, 2009. 54(2): p. 273-281.
10. Itoh, N., et al., Roles of FGF signals in heart development, health, and disease. Frontiers in cell and developmental biology, 2016. 4: p. 110.
11. Kokkinos, J., et al., The role of fibroblast growth factor 21 in atherosclerosis. Atherosclerosis, 2017. 257: p. 259-265.
12. Itoh, N. and H. Ohta, Pathophysiological roles of FGF signaling in the heart. Frontiers in Physiology, 2013. 4: p. 247.
13. Dutchak, P.A., et al., Fibroblast growth factor-21 regulates PPARγ activity and the antidiabetic actions of thiazolidinediones. Cell, 2012. 148(3): p. 556-567.
14. Videla, L.A., et al., Upregulation of rat liver PPARα‐FGF21 signaling by a docosahexaenoic acid and thyroid hormone combined protocol. Biofactors, 2016. 42(6): p. 638-646.
15. Taniguchi, H., et al., Acute endurance exercise lowers serum fibroblast growth factor 21 levels in Japanese men. Clinical Endocrinology, 2016. 85(6): p. 861-867.
16. Cuevas-Ramos, D., et al., Exercise increases serum fibroblast growth factor 21 (FGF21) levels. PloS one, 2012. 7(5): p. e38022.
17. Scalzo, R.L., et al., Regulators of human white adipose browning: evidence for sympathetic control and sexual dimorphic responses to sprint interval training. PloS one, 2014. 9(3): p. e90696.
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