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Archives of Medical Laboratory Sciences

Vol. 7 (2021)

March 2021

Deep Characterization of SARS-CoV-2: An Overview

  • Ehsan Ul Haq

Archives of Medical Laboratory Sciences, Vol. 7 (2021), 13 March 2021 , Page 1-6 (e2)
https://doi.org/10.22037/amls.v7.33616 Published: 2021-05-15

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Abstract

The coronavirus epidemic has become one of the major health concerns all over the world recently. Like other strains of coronavirus, this strain also spreads through a droplet-based transmission that is the main cause of its worldwide spread. Several trials of antiviral medicines related to the control of the virus have already begun globally but still one of the main problems is the lack of a viable treatment option. An extensive amount of research is still taking place to organize the data associated with genomics and proteomics of its original strain SARS-CoV-2 alongside other mutant strains. This review summarizes the related up-to-date research that is going on the structural organization of the genome and proteome of the virus.

*Corresponding Author: Ehsan Ul Haq; Email: ehsanulhaqsani5@gmail.com; BBTF17E116@uos.edu.pk

Please cite this article as: Ul Haq E. Deep Characterization of SARS-CoV-2: An Overview. Arch Med Lab Sci. 2021;7:1-6 (e2). https://doi.org/10.22037/amls.v7.33616

Keywords:
  • SARS-CoV-2
  • Coronavirus
  • Structural Organization
  • Replication
  • Genomics
  • Proteomics
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How to Cite

1.
Ul Haq E. Deep Characterization of SARS-CoV-2: An Overview. Arch Med Lab Sci [Internet]. 2021 May 15 [cited 2026 Jul. 8];7(1):1-6 (e2). Available from: https://journals.sbmu.ac.ir/index.php/medlab/article/view/33616
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References

Paraskevis D, Kostaki EG, Magiorkinis G, Panayiotakopoulos G, Sourvinos G, Tsiodras S. Full-genome evolutionary analysis of the novel coronavirus (2019-nCoV) rejects the hypothesis of emergence as a result of a recent recombination event. Infect Genet Evol. 2020 Apr;79:104212. doi: 10.1016/j.meegid.2020.104212. Epub 2020 Jan 29. PMID: 32004758; PMCID: PMC7106301.

Wang Y, Zhou Y, Yang Z, Xia D, Hu Y, Geng S. Clinical Characteristics of Patients with Severe Pneumonia Caused by the SARS-CoV-2 in Wuhan, China. Respiration. 2020;99(8):649-657. doi: 10.1159/000507940. Epub 2020 Aug 25. PMID: 32841948; PMCID: PMC7490495.

Walls A, Park Y, Tortorici M, Wall A, McGuire A, Veesler D. Structure, function and antigenicity of the SARS-CoV-2 spike glycoprotein. 2020;.

Corman VM, Muth D, Niemeyer D, Drosten C. Hosts and Sources of Endemic Human Coronaviruses. Adv Virus Res. 2018;100:163-188. doi: 10.1016/bs.aivir.2018.01.001. Epub 2018 Feb 16. PMID: 29551135; PMCID: PMC7112090.

Phan T. Novel coronavirus: From discovery to clinical diagnostics. Infect Genet Evol. 2020 Apr;79:104211. doi: 10.1016/j.meegid.2020.104211. Epub 2020 Jan 30. PMID: 32007627; PMCID: PMC7129799.

Chan JF, Kok KH, Zhu Z, Chu H, To KK, Yuan S, et al. Genomic characterization of the 2019 novel human-pathogenic coronavirus isolated from a patient with atypical pneumonia after visiting Wuhan. Emerg Microbes Infect. 2020 Jan 28;9(1):221-236. doi: 10.1080/22221751.2020.1719902. Erratum in: Emerg Microbes Infect. 2020 Dec;9(1):540. PMID: 31987001; PMCID: PMC7067204.

Xia S, Liu M, Wang C, Xu W, Lan Q, Feng S, et al. Inhibition of SARS-CoV-2 (previously 2019-nCoV) infection by a highly potent pan-coronavirus fusion inhibitor targeting its spike protein that harbors a high capacity to mediate membrane fusion. Cell Res. 2020 Apr;30(4):343-355. doi: 10.1038/s41422-020-0305-x. Epub 2020 Mar 30. PMID: 32231345; PMCID: PMC7104723.

Fehr AR, Perlman S. Coronaviruses: an overview of their replication and pathogenesis. Methods Mol Biol. 2015;1282:1-23. doi: 10.1007/978-1-4939-2438-7_1. PMID: 25720466; PMCID: PMC4369385.

Marra MA, Jones SJ, Astell CR, Holt RA, Brooks-Wilson A, Butterfield YS, et al. The Genome sequence of the SARS-associated coronavirus. Science. 2003 May 30;300(5624):1399-404. doi: 10.1126/science.1085953. Epub 2003 May 1. PMID: 12730501.

Thiel V, Ivanov KA, Putics Á, Hertzig T, Schelle B, Bayer S, et al. Mechanisms and enzymes involved in SARS coronavirus genome expression. J Gen Virol. 2003 Sep;84(Pt 9):2305-2315. doi: 10.1099/vir.0.19424-0. PMID: 12917450.

Xiong B, Gui CS, Xu XY, Luo C, Chen J, Luo HB, et al. A 3D model of SARS_CoV 3CL proteinase and its inhibitors design by virtual screening. Acta Pharmacol Sin. 2003 Jun;24(6):497-504. PMID: 12791174.

Anand K, Ziebuhr J, Wadhwani P, Hilgenfeld R, Mesters JR. Coronavirus Main Proteinase (3CLpro) Structure: Basis for Design of Anti-SARS Drugs. Science. 2003 Jun 13;300(5626)(5626):1763-1767. https://doi.org/10.1126/science.1085658

Ziebuhr J, Snijder EJ, Gorbalenya AE. Virus-encoded proteinases and proteolytic processing in the Nidovirales. J Gen Virol. 2000 Apr;81(Pt 4):853-79. doi: 10.1099/0022-1317-81-4-853. PMID: 10725411.

Han DP, Kim HG, Kim YB, Poon LL, Cho MW. Development of a safe neutralization assay for SARS-CoV and characterization of S-glycoprotein. Virology. 2004 Aug 15;326(1):140-9. doi: 10.1016/j.virol.2004.05.017. PMID: 15262502; PMCID: PMC7127165.

Huang Y, Yang C, Xu XF, Xu W, Liu SW. Structural and functional properties of SARS-CoV-2 spike protein: potential antivirus drug development for COVID-19. Acta Pharmacol Sin. 2020 Sep;41(9):1141-1149. doi: 10.1038/s41401-020-0485-4. Epub 2020 Aug 3. PMID: 32747721; PMCID: PMC7396720.

Li W, Moore MJ, Vasilieva N, Sui J, Wong SK, Berne MA, et al. Angiotensin-converting enzyme 2 is a functional receptor for the SARS coronavirus. Nature. 2003 Nov 27;426(6965):450-4. doi: 10.1038/nature02145. PMID: 14647384; PMCID: PMC7095016.

Rota PA, Oberste MS, Monroe SS, Nix WA, Campagnoli R, Icenogle JP, et al. Characterization of a novel coronavirus associated with severe acute respiratory syndrome. Science. 2003 May 30;300(5624):1394-9. doi: 10.1126/science.1085952. Epub 2003 May 1. PMID: 12730500.

Luo H, Ye F, Sun T, Yue L, Peng S, Chen J, et al. In vitro biochemical and thermodynamic characterization of nucleocapsid protein of SARS. Biophys Chem. 2004 Dec 1;112(1):15-25. doi: 10.1016/j.bpc.2004.06.008. PMID: 15501572; PMCID: PMC7116930.

Wang Y, Wu X, Wang Y, Li B, Zhou H, Yuan G, et al. Low stability of nucleocapsid protein in SARS virus. Biochemistry. 2004 Aug 31;43(34):11103-8. doi: 10.1021/bi049194b. PMID: 15323569.

Huang C, Wei P, Fan K, Liu Y, Lai L. 3C-like proteinase from SARS coronavirus catalyzes substrate hydrolysis by a general base mechanism. Biochemistry. 2004 Apr 20;43(15):4568-74. doi: 10.1021/bi036022q. PMID: 15078103.

Arbely E, Khattari Z, Brotons G, Akkawi M, Salditt T, Arkin IT. A highly unusual palindromic transmembrane helical hairpin formed by SARS coronavirus E protein. J Mol Biol. 2004 Aug 13;341(3):769-79. doi: 10.1016/j.jmb.2004.06.044. PMID: 15288785; PMCID: PMC7134595.

Surya W, Li Y, Verdià-Bàguena C, Aguilella VM, Torres J. MERS coronavirus envelope protein has a single transmembrane domain that forms pentameric ion channels. Virus Res. 2015 Apr 2;201:61-6. doi: 10.1016/j.virusres.2015.02.023. Epub 2015 Feb 27. PMID: 25733052; PMCID: PMC7114494.

Wilson L, McKinlay C, Gage P, Ewart G. SARS coronavirus E protein forms cation-selective ion channels. Virology. 2004 Dec 5;330(1):322-31. doi: 10.1016/j.virol.2004.09.033. PMID: 15527857; PMCID: PMC7111769.

Tan YJ, Lim SG, Hong W. Characterization of viral proteins encoded by the SARS-coronavirus genome. Antiviral Res. 2005 Feb;65(2):69-78. doi: 10.1016/j.antiviral.2004.10.001. PMID: 15708633; PMCID: PMC7114173.

Hoffmann M, Kleine-Weber H, Schroeder S, Krüger N, Herrler T, Erichsen S, et al. SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor. Cell. 2020 Apr 16;181(2):271-280.e8. doi: 10.1016/j.cell.2020.02.052. Epub 2020 Mar 5. PMID: 32142651; PMCID: PMC7102627.

Shirato K, Kawase M, Matsuyama S. Wild-type human coronaviruses prefer cell-surface TMPRSS2 to endosomal cathepsins for cell entry. Virology. 2018 Apr;517:9-15. doi: 10.1016/j.virol.2017.11.012. Epub 2017 Dec 6. PMID: 29217279; PMCID: PMC7112029.

He J, Hu L, Huang X, Wang C, Zhang Z, Wang Y, et al. Potential of coronavirus 3C-like protease inhibitors for the development of new anti-SARS-CoV-2 drugs: Insights from structures of protease and inhibitors. Int J Antimicrob Agents. 2020 Aug;56(2):106055. doi: 10.1016/j.ijantimicag.2020.106055. Epub 2020 Jun 11. PMID: 32534187; PMCID: PMC7286838.

McKimm-Breschkin JL. Influenza neuraminidase inhibitors: antiviral action and mechanisms of resistance. Influenza Other Respir Viruses. 2013 Jan;7 Suppl 1(Suppl 1):25-36. doi: 10.1111/irv.12047. PMID: 23279894; PMCID: PMC4942987.

Alanagreh L, Alzoughool F, Atoum M. The Human Coronavirus Disease COVID-19: Its Origin, Characteristics, and Insights into Potential Drugs and Its Mechanisms. Pathogens. 2020 Apr 29;9(5):331. doi: 10.3390/pathogens9050331. PMID: 32365466; PMCID: PMC7280997.

Rahman HS, Aziz MS, Hussein RH, Othman HH, Salih Omer SH, Khalid ES, Abdulrahman NA, Amin K, Abdullah R. The transmission modes and sources of COVID-19: A systematic review. International Journal of Surgery Open. 2020;26:125–36. doi: 10.1016/j.ijso.2020.08.017. Epub 2020 Sep 11. PMCID: PMC7484735.

Schoeman D, Fielding BC. Coronavirus envelope protein: current knowledge. Virol J. 2019 May 27;16(1):69. doi: 10.1186/s12985-019-1182-0. PMID: 31133031; PMCID: PMC6537279.

Katsnelson, A., 2021. What do we know about the novel coronavirus’s 29 proteins?. (online) Cen.acs.org. Available at: <https://cen.acs.org/biological-chemistry/infectious-disease/know-novel-coronaviruss-29-proteins/98/web/2020/04> (Accessed 3 January 2021).

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The journal of "Archives of Medical Laboratory Sciences" is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

                       Print ISSN: ‪2423-6241; Online ISSN: 2476-7670

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