Seroprevalence of Hepatitis B and C in Coronary Artery Disease Patients in Urmia, Northwest of Iran
Archives of Medical Laboratory Sciences,
Vol. 5 No. 1 (2019),
29 March 2020
,
Page 18-22
https://doi.org/10.22037/amls.v5i1.28473
Abstract
Background: Coronary artery disease (CAD) is one of the main causes of death all over the world. Predisposing factors comprise some infectious etiologies with systemic effects such as the hepatitis C virus and HBV-infection might be related to CAD from chronic inflammation process. The relationships between hepatitis B and C virus (HBV and HCV) infections and CAD considered a noticeable health problem. In the present study, we evaluated the seropositivity of HCV and HBV in CAD patients from the Iranian population.
Materials and Methods: We conducted a cohort study including 192 CAD subjects. To identify HCV and HBV -infected subjects, a serologic examination comprising Hepatitis B surface antigen (HBsAg) and anti-HCV antibodies (HCV-Ab) tests performed by ELISA method. Also, we examined the biochemical blood parameters such as lipid profile, glycemic parameters, and blood inflammatory factor (C-reactive protein).
Results: We identified a very low percent of HBV-infected cases (1.04%). All examined CAD patients indicate the HCV Ab-negative results. The HBV-infected subject had not, hyperlipidemia, and diabetes. HBV infection was not related to the increased risk of CAD. Also, CAD risk factors were not associated with the prevalence of HBV and HCV.
Conclusion: According to the results, HCV and HBV infections had very low prevalence in examined subjects and there was not any association between CAD and prevalence of HCV and HBV infections.
- Hepatitis B Virus
- Hepatitis C Virus
- Coronary Artery Disease
- Iran
How to Cite
References
Hatmi Z, Tahvildari S, Gafarzadeh Motlag A, Sabouri Kashani A. Prevalence of coronary artery disease risk factors in Iran: a population based survey. BMC Cardiovascular Disorders. 2007;7:32.
Wijarnpreecha K, Thongprayoon C, Panjawatanan P, Ungprasert P. Hepatitis B virus infection and risk of coronary artery disease: a meta-analysis. Annals of Translational Medicine. 2016;4(21):423. doi:10.21037/atm.2016.11.12.
Petta S, Maida M, Macaluso FS, et al. Hepatitis C Virus Infection Is Associated With Increased Cardiovascular Mortality: A Meta-Analysis of Observational Studies. Gastroenterology 2016;150:145-155.e4; quiz e15-6.
Ungprasert P, Wijarnpreecha K, Ahuja W, et al. Coronary artery disease in primary biliary cirrhosis: A systematic review and meta-analysis of observational studies. Hepatol Res 2015;45:1055-61.
Ungprasert P, Suksaranjit P, Spanuchart I, et al. Risk of coronary artery disease in patients with idiopathic inflammatory myopathies: a systematic review and meta-analysis of observational studies. Semin Arthritis Rheum 2014;44:63-7.
Ungprasert P, Srivali N, Kittanamongkolchai W, et al. Risk of coronary artery disease in patients with ankylosing spondylitis: a systematic review and meta-analysis. Ann Transl Med 2015; 3:51.
Salehi-Vaziri M, Sadeghi F, Hashiani AA, Fesharaki MG, Alavian SM. Hepatitis B virus infection in the general population of Iran: an updated systematic review and meta-analysis. Hepat mon. 2016;16:e35577.
Taherkhani R, Farshadpour F. Epidemiology of hepatitis C virus in Iran. 2015; 14; 21(38): 10790–10810.
Shoeib O, Ashmawy M, Badr S, El Amroosy M.Association between coronary artery disease and hepatitis C virus seropositivity. East Mediterr Health J. 2018 . 6;24(7):618-623.
Wen D, Du X, Dong JZ, Ma CS.Hepatitis C virus infection and risk of coronary artery disease: A meta-analysis. Eur J Intern Med. 2019 May;63:69-73.
Babiker A, Jeudy J, Kligerman S, Khambaty M, Shah A, Bagchi S. Risk of Cardiovascular
Disease Due to Chronic Hepatitis C Infection: A Review. Journal of Clinical and Translational Hepatology. 2017; 5(4):343-362.
Butt AA, Xiaoqiang W, Budoff M, Leaf D, Kuller LH, Justice AC. Hepatitis C Virus Infection and the Risk of Coronary Disease. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America. 2009;49(2):225-232.
Guiltinan AM, Kaidarova Z, Custer B, et al. Increased all-cause, liver, and cardiac mortality among hepatitis C virus-seropositive blood donors. Am J Epidemiol 2008;167:743-50.
Ghotaslou R, Aslanabadi N, Ghojazadeh M. Hepatitis B virus infection and the risk of coronary atherosclerosis. Ann Acad Med Singapore 2008;37:913-5.
Ishizaka N, Ishizaka Y, Takahashi E, Toda EE, Hashimoto H, Ohno M, et al. Increased prevalence of carotid atherosclerosis in hepatitis B virus carriers. Circulation. 2002;105(9):1028–30.
Arcari CM, Nelson KE, Netski DM, Nieto FJ, Gaydos CA. No association between hepatitis C virus seropositivity and acute myocardial infarction. Clin Infect Dis. 2006;43(6):53–e56.
Miyajima I, Kawaguchi T, Fukami A, Nagao Y, Adachi H, Sasaki S, et al. Chronic HCV infection was associated with severe insulin resistance and mild atherosclerosis: a population-based study in an HCV hyperendemic area. J Gastroenterol. 2013;48(1):93–100.
Dala AG, Hamed WA, Badr MH, Omar RM. Hepatitis C as a risk factor for coronary artery disease in silent myocardial ischemia. Menoufia Med J 2017;30:818-22.
- Abstract Viewed: 144 times
- pdf Downloaded: 82 times