The effects of cholesterol lowering drugs on vitamin D status in familial hypercholesterolemia patients
Archives of Medical Laboratory Sciences,
Vol. 3 No. 4 (2017),
26 September 2018
https://doi.org/10.22037/amls.v3i4.19099
Abstract
Background: Familial high blood cholesterol (hypercholesterolemia) is a common disease that involves many complications for patients. The aim of this study is to investigate the effects of cholesterol-lowering drugs (Gemfibrozil and Atorvastatin) on the level of serum Vitamin D.
Materials and methods: In this study, the 25-hydroxy vitamin D levels were evaluated in 65 women between 30-55 years of age. After receiving drug information of patients, cholesterol-lowering medication; Gemfibrozil and Atorvastatin were prescribed by a specialist, then vitamin D and cholesterol levels were measured following 9 month treatment. Also 30 patients consumed vitamin D supplements plus medicine regularly.
Results: In the first stage, vitamin D levels in subjects are quite normal but their cholesterol levels were higher than normal. In the second stage, vitamin D levels were measured after 9 months use of Gemfibrozil and Atorvastatin. Accordingly, cholesterol levels decreased significantly due to the use of blood cholesterol-lowering drugs (p=0.021). Also, in this stage the level of vitamin D showed a severe and significant reduction (p=0.041). However, there were no significant reductions in vitamin D in 30 women who consumed vitamin D supplements plus medicine (p=0.073).
Conclusion: It seems that taking cholesterol-lowering medicines have reduced the amount of vitamin D. With long-term use of medications, bone diseases such as osteoporosis can be predicted in these individuals. Therefore, taking supplements and food rich in vitamin D during the use of these drugs is recommended.
- Hypercholesterolemia
- Vitamin D
- ELISA
How to Cite
References
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