The effect of cell derived microparticles in transfusion medicine and adaptive immune system
Archives of Medical Laboratory Sciences,
Vol. 2 No. 1 (2016),
9 April 2016
https://doi.org/10.22037/amls.v2i1.13796
Abstract
This article reviews will focus on the concept and formation of micro particles (MPs) in circulation and their role in transfusion medicine and immune system. MPs are cell membrane derived vesicles which express markers of their parent cells and are found in circulation at low levels. Exact functions of MPs are unclear. In here, Physiological almost all types of circulating MPs including platelets MPs (PMPs), leukocytes MPs (LMPs), red blood cells MPs (RMPs) and endothelial cells MPs (EMPs) have been discussed. Furthermore, MPs present in plasma and blood products and their levels increase during storage. Thus, it can be stated that MPs are likely to cause transfusion reactions, particularly thrombotic complications and Transfusion-Related Acute Lung Injury (TRALI). Also, it is shown that the MPs may affect the immune system. However, to prove these, more and extensive studies both in vivo and in vitro need to be done.
- Microparticles
- platelets
- transfusion medicine
- adaptive immunity
How to Cite
References
Diamant M, Tushuizen ME, Sturk A, Nieuwland R. Cellular microparticles: new players in the field of vascular disease? European journal of clinical investigation. 2004;34(6):392-401.
Simak J, Gelderman MP. Cell membrane microparticles in blood and blood products: potentially pathogenic agents and diagnostic markers. Transfusion medicine reviews. 2006;20(1):1-26.
Rubin O, Crettaz D, Tissot JD, Lion N. Microparticles in stored red blood cells: submicron clotting bombs? Blood transfusion = Trasfusione del sangue. 2010;8 Suppl 3:s31-8.
Garcia BA, Smalley DM, Cho H, Shabanowitz J, Ley K, Hunt DF. The platelet microparticle proteome. Journal of proteome research. 2005;4(5):1516-21.
Miguet L, Pacaud K, Felden C, Hugel B, Martinez MC, Freyssinet JM, et al. Proteomic analysis of malignant lymphocyte membrane microparticles using double ionization coverage optimization. Proteomics. 2006;6(1):153-71.
Choi DS, Lee JM, Park GW, Lim HW, Bang JY, Kim YK, et al. Proteomic analysis of microvesicles derived from human colorectal cancer cells. Journal of proteome research. 2007;6(12):4646-55.
Keller S, Rupp C, Stoeck A, Runz S, Fogel M, Lugert S, et al. CD24 is a marker of exosomes secreted into urine and amniotic fluid. Kidney international. 2007;72(9):1095-102.
Choi DS, Park JO, Jang SC, Yoon YJ, Jung JW, Choi DY, et al. Proteomic analysis of microvesicles derived from human colorectal cancer ascites. Proteomics. 2011;11(13):2745-51.
Admyre C, Johansson SM, Qazi KR, Filen JJ, Lahesmaa R, Norman M, et al. Exosomes with immune modulatory features are present in human breast milk. Journal of immunology (Baltimore, Md : 1950). 2007;179(3):1969-78.
Ogawa Y, Kanai-Azuma M, Akimoto Y, Kawakami H, Yanoshita R. Exosome-like vesicles with dipeptidyl peptidase IV in human saliva. Biological & pharmaceutical bulletin. 2008;31(6):1059-62.
Choi DS, Kim DK, Kim YK, Gho YS. Proteomics, transcriptomics and lipidomics of exosomes and ectosomes. Proteomics. 2013;13(10-11):1554-71.
De Maio A. Extracellular heat shock proteins, cellular export vesicles, and the Stress Observation System: a form of communication during injury, infection, and cell damage. It is never known how far a controversial finding will go! Dedicated to Ferruccio Ritossa. Cell stress & chaperones. 2011;16(3):235-49.
Gyorgy B, Szabo TG, Pasztoi M, Pal Z, Misjak P, Aradi B, et al. Membrane vesicles, current state-of-the-art: emerging role of extracellular vesicles. Cellular and molecular life sciences : CMLS. 2011;68(16):2667-88.
Diehl P, Fricke A, Sander L, Stamm J, Bassler N, Htun N, et al. Microparticles: major transport vehicles for distinct microRNAs in circulation. Cardiovascular research. 2012;93(4):633-44.
Raimondo F, Morosi L, Chinello C, Magni F, Pitto M. Advances in membranous vesicle and exosome proteomics improving biological understanding and biomarker discovery. Proteomics.
;11(4):709-20.
Jin M, Drwal G, Bourgeois T, Saltz J, Wu HM. Distinct proteome features of plasma microparticles. Proteomics. 2005;5(7):1940-52.
VanWijk MJ, VanBavel E, Sturk A, Nieuwland R. Microparticles in cardiovascular diseases. Cardiovascular research. 2003;59(2):277-87.
Simons M, Raposo G. Exosomes--vesicular carriers for intercellular communication. Current opinion in cell biology. 2009;21(4):575-81.
Thery C, Ostrowski M, Segura E. Membrane vesicles as conveyors of immune responses. Nature reviews Immunology. 2009;9(8):581-93.
Distler JH, Pisetsky DS, Huber LC, Kalden JR, Gay S, Distler O. Microparticles as regulators of inflammation: novel players of cellular crosstalk in the rheumatic diseases. Arthritis and rheumatism. 2005;52(11):3337-48.
Hristov M, Erl W, Linder S, Weber PC. Apoptotic bodies from endothelial cells enhance the number and initiate the differentiation of human endothelial progenitor cells in vitro. Blood. 2004;104(9):2761-6.
Wolf P. The nature and significance of platelet products in human plasma. British journal of haematology. 1967;13(3):269-88.
Rubin O, Canellini G, Delobel J, Lion N, Tissot JD. Red blood cell microparticles: clinical relevance. Transfusion medicine and hemotherapy : offizielles Organ der Deutschen Gesellschaft fur Transfusionsmedizin und Immunhamatologie. 2012;39(5):342-7.
Piccin A, Murphy WG, Smith OP. Circulating microparticles: pathophysiology and clinical implications. Blood reviews. 2007;21(3):157-71.
Hugel B, Martinez MC, Kunzelmann C, Freyssinet JM. Membrane microparticles: two sides of the coin. Physiology (Bethesda, Md). 2005;20:22-7.
Comfurius P, Bevers EM, Galli M, Zwaal RF. Regulation of phospholipid asymmetry and induction of antiphospholipid antibodies. Lupus. 1995;4 Suppl 1:S19-22.
Freyssinet JM, Toti F. Formation of procoagulant microparticles and properties. Thrombosis research. 2010;125 Suppl 1:S46-8.
Rubin O, Crettaz D, Canellini G, Tissot JD, Lion N. Microparticles in stored red blood cells: an approach using flow cytometry and proteomic tools. Vox sanguinis. 2008;95(4):288-97.
Rumsby MG, Trotter J, Allan D, Michell RH. Recovery of membrane micro-vesicles from human erythrocytes stored for transfusion: a mechanism for the erythrocyte discocyte-to-spherocyte shape transformation. Biochemical Society transactions. 1977;5(1):126-8.
Shukla SD, Coleman R, Finean JB, Michell RH. The use of phospholipase c to detect structural changes in the membranes of human erythrocytes aged by storage. Biochimica et biophysica acta. 1978;512(2):341-9.
Ferru E, Giger K, Pantaleo A, Campanella E, Grey J, Ritchie K, et al. Regulation of membrane-cytoskeletal interactions by tyrosine phosphorylation of erythrocyte band 3. Blood. 2011;117(22):5998-6006.
Tissot JD, Rubin O, Canellini G. Analysis and clinical relevance of microparticles from red blood cells. Current opinion in hematology. 2010;17(6):571-7.
Lawrie AS, Albanyan A, Cardigan RA, Mackie IJ, Harrison P. Microparticle sizing by dynamic light scattering in fresh-frozen plasma. Vox sanguinis. 2009;96(3):206-12.
Antonelou MH, Kriebardis AG, Stamoulis KE, Economou-Petersen E, Margaritis LH, Papassideri IS. Red blood cell aging markers during storage in citrate-phosphate-dextrose-saline-adenine-glucose-mannitol. Transfusion. 2010;50(2):376-89.
Greenwalt TJ, Zehner Sostok C, Dumaswala UJ. Studies in red blood cell preservation. 1. Effect of the other formed elements. Vox sanguinis. 1990;58(2):85-9.
Blajchman MA, Beckers EA, Dickmeiss E, Lin L, Moore G, Muylle L. Bacterial detection of platelets: current problems and possible resolutions. Transfusion medicine reviews. 2005;19(4):259-72.
Holme S, Moroff G, Murphy S. A multi-laboratory evaluation of in vitro platelet assays: the tests for extent of shape change and response to hypotonic shock. Biomedical Excellence for Safer Transfusion Working Party of the International Society of Blood Transfusion. Transfusion. 1998;38(1):31-40.
Curvers J, van Pampus EC, Feijge MA, Rombout-Sestrienkova E, Giesen PL, Heemskerk JW. Decreased responsiveness and development of activation markers of PLTs stored in plasma. Transfusion. 2004;44(1):49-58.
Fox JE, Austin CD, Reynolds CC, Steffen PK. Evidence that agonist-induced activation of calpain causes the shedding of procoagulant-containing microvesicles from the membrane of aggregating platelets. The Journal of biological chemistry. 1991;266(20):13289-95.
Seghatchian J. A new platelet storage lesion index based on paired samples, without and with EDTA and cell counting: comparison of three types of leukoreduced preparations. Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis. 2006;35(3):283-92.
Yari F, Azadpour S, Shiri R. Platelet storage media change the expression characteristics of the platelet-derived microparticles. Indian journal of hematology & blood transfusion : an official journal of Indian Society of Hematology and Blood Transfusion. 2014;30(3):169-74.
George JN, Pickett EB, Heinz R. Platelet membrane microparticles in blood bank fresh frozen plasma and cryoprecipitate. Blood. 1986;68(1):307-9.
Lawrie AS, Harrison P, Cardigan RA, Mackie IJ. The characterization and impact of microparticles on haemostasis within fresh-frozen plasma. Vox sanguinis. 2008;95(3):197-204.
Krailadsiri P, Seghatchian J, Macgregor I, Drummond O, Perrin R, Spring F, et al. The effects of leukodepletion on the generation and removal of microvesicles and prion protein in blood components. Transfusion. 2006;46(3):407-17.
Lawrie AS, Cardigan RA, Williamson LM, Machin SJ, Mackie IJ. The dynamics of clot formation in fresh-frozen plasma. Vox sanguinis. 2008;94(4):306-14.
Jy W, Horstman LL, Wang F, Duncan RC, Ahn YS. Platelet factor 3 in plasma fractions: its relation to microparticle size and thromboses. Thrombosis research. 1995;80(6):471-82.
Bidot L, Jy W, Bidot C, Jr., Jimenez JJ, Fontana V, HorstmanLL, et al. Microparticle-mediated thrombin generation assay: increased activity in patients with recurrent thrombosis. Journal of thrombosis and haemostasis : JTH. 2008;6(6):913-9.
Zwaal RF, Comfurius P, Bevers EM. Platelet procoagulant activity and microvesicle formation. Its putative role in hemostasis and thrombosis. Biochimica et biophysica acta. 1992;1180(1):1-8.
Gao Y, Lv L, Liu S, Ma G, Su Y. Elevated levels of thrombin-generating microparticles in stored red blood cells. Vox sanguinis. 2013;105(1):11-7.
Spinella PC, Carroll CL, Staff I, Gross R, Mc Quay J, Keibel L, et al. Duration of red blood cell storage is associated with increased incidence of deep vein thrombosis and in hospital mortality in patients with traumatic injuries. Critical care (London, England). 2009;13(5):R151.
Bux J, Sachs UJ. The pathogenesis of transfusion-related acute lung injury (TRALI). British journal of haematology. 2007;136(6):788-99.
Tung JP, Fung YL, Nataatmadja M, Colebourne KI, Esmaeel HM, Wilson K, et al. A novel in vivo ovine model of transfusion-related acute lung injury (TRALI). Vox sanguinis. 2011;100(2):219-30.
Kopko PM, Marshall CS, MacKenzie MR, Holland PV, Popovsky MA. Transfusion-related acute lung injury: report of a clinical look-back investigation. Jama. 2002;287(15):1968-71.
Maslanka K, Michur H, Zupanska B, Uhrynowska M, Nowak J. Leucocyte antibodies in blood donors and a look back on recipients of their blood components. Vox sanguinis. 2007;92(3):247-9.
Silliman CC, Voelkel NF, Allard JD, Elzi DJ, Tuder RM, Johnson JL, et al. Plasma and lipids from stored packed red blood cells cause acute lung injury in an animal model. The Journal of clinical investigation. 1998;101(7):1458-67.
Jy W, Mao WW, Horstman L, Tao J, Ahn YS. Platelet microparticles bind, activate and aggregate neutrophils in vitro. Blood cells, molecules & diseases. 1995;21(3):217-31; discussion 31a.
Vandendries ER, Furie BC, Furie B. Role of P-selectin and PSGL-1 in coagulation and thrombosis. Thrombosis and haemostasis. 2004;92(3):459-66.
Bosman GJ, Lasonder E, Luten M, Roerdinkholder-Stoelwinder B, Novotny VM, Bos H, et al. The proteome of red cell membranes and vesicles during storage in blood bank conditions. Transfusion. 2008;48(5):827-35.
Inwald DP, McDowall A, Peters MJ, Callard RE, Klein NJ. CD40 is constitutively expressed on platelets and provides a novel mechanism for platelet activation. Circulation research. 2003;92(9):1041-8.
Phipps RP, Kaufman J, Blumberg N. Platelet derived CD154 (CD40 ligand) and febrile responses to transfusion. Lancet (London, England). 2001;357(9273):2023-4.
Khan SY, Kelher MR, Heal JM, Blumberg N, Boshkov LK, Phipps R, et al. Soluble CD40 ligand accumulates in stored blood components, primes neutrophils through CD40, and is a potential cofactor in the development of transfusion-related acute lung injury. Blood. 2006;108(7):2455-62.
Ahn ER, Lander G, Jy W, Bidot CJ, Jimenez JJ, Horstman LL, et al. Differences of soluble CD40L in sera and plasma: implications on CD40L assay as a marker of thrombotic risk. Thrombosis research. 2004;114(2):143-8.
Xie RF, Hu P, Li W, Ren YN, Yang J, Yang YM, et al. The effect of platelet-derived microparticles in stored apheresis platelet concentrates on polymorphonuclear leucocyte respiratory burst. Vox sanguinis. 2014;106(3):234-41.
Maslanka K, Uhrynowska M, Lopacz P, Wrobel A, Smolenska-Sym G, Guz K, et al. Analysis of leucocyte antibodies, cytokines, lysophospholipids and cell microparticles in blood components implicated in post-transfusion reactions with dyspnoea. Vox sanguinis. 2015;108(1):27-36.
Sadallah S, Eken C, Schifferli JA. Ectosomes as modulators of inflammation and immunity. Clinical and experimental immunology. 2011;163(1):26-32.
Sadallah S, Eken C, Schifferli JA. Ectosomes as immunomodulators. Seminars in immunopathology. 2011;33(5):487-95.
Johnstone RM. Exosomes biological significance: A concise review. Blood cells, molecules & diseases. 2006;36(2):315-21.
Norling LV, Dalli J. Microparticles are novel effectors of immunity. Current opinion in pharmacology. 2013;13(4):570-5.
Brown GT, McIntyre TM. Lipopolysaccharide signaling without a nucleus: kinase cascades stimulate platelet shedding of proinflammatory IL-1beta-rich microparticles. Journal of immunology (Baltimore, Md : 1950). 2011;186(9):5489-96.
Cognasse F, Hamzeh-Cognasse H, Lafarge S, Chavarin P, Cogne M, Richard Y, et al. Human platelets can activate peripheral blood B cells and increase production of immunoglobulins. Experimental hematology. 2007;35(9):1376-87.
Sprague DL, Elzey BD, Crist SA, Waldschmidt TJ, Jensen RJ, Ratliff TL. Platelet-mediated modulation of adaptive immunity: unique delivery of CD154 signal by platelet-derived membrane vesicles. Blood. 2008;111(10):5028-36.
Esmaili MA, Yari F, Sharifi Z, Nikougoftar M, Fadaei R. Effects of Platelet Microparticles on the Activation of B Cells. Modares Journal of Medical Sciences: Pathobiology. 2013;15(4):1-10.
Jahromi M, Yari F, Esmaeili MA. Effect of Platelet-derived Microparticles on the Production of IgG Antibody from Human Peripheral Blood B-Lymphocytes. Journal of Mazandaran University of Medical Sciences. 2016;25(133):267-76.
Skokos D, Le Panse S, Villa I, Rousselle JC, Peronet R, David B, et al. Mast cell-dependent B and T lymphocyte activation is mediated by the secretion of immunologically active exosomes. Journal of immunology (Baltimore, Md : 1950). 2001;166(2):868-76.
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