Advances in Nursing & Midwifery

Abstract

Abstract
Background
Pemphigus is a rare and potentially life-threatening disease. It produces blisters in the skin and
mucous membranes. In more than 81% of cases, pemphigus involves oral mucosa. This study
assessed the efficacy of mouthwash with honey compared with hydrogen peroxide on oral lesions
healing in Pemphigus patients.
Materials and methods
A randomized design clinical trial was carried on 49 patients with oral pemphigus lesions. Patients
randomly divided into experimental and control groups. Patients were assessed for 10 days. Data
were collected by questionnaire, Oral Mucositis Visual Assessment Guide of WHO, visual analog
scale of pain intensity and time Diaries.
Results
Age, sex, educational level, marital status, history of crisis in the past 6 months, history of
autoimmune disease and history of pemphigus disease in their family, were not statistically
significant differente in experimental (honey mouthwash) and control (hydrogen peroxide
mouthwash) groups. Degree of oral lesions faster was improved in experimental (honey mouthwash)
group compared with control (hydrogen peroxide mouthwash) group. Reducing pain intensity in the
experimental group was significant from the third day(P = 0.001), while it was not statistically
significant in the control group until the tenth day of assessment.
Conclusion
Honey mouthwash compared with hydrogen peroxide has had faster effect on oral lesions healing
and more effective on reducing pain in pemphigus patients. Honey mouthwash has no complication
in this group of patients.
Key words: pemphigus, oral lesions, honey, Hydrogen peroxide