Treatment of 2, 4-Dichlorophenoxyacetic Acid (2, 4-D) Poisoning; a Case Study
International Journal of Medical Toxicology and Forensic Medicine,
Vol. 4 No. 3(Summer) (2014),
Background: 2, 4-Dichlorophenoxyacetic Acid (2, 4-D) is an herbicide in chlorophenoxy group that use as a weed killer. Acute poisoning with 2, 4-D may be fatal in large ingestion. There is no specific antidote for 2, 4-D herbicide poisoning. We report here a case of 2, 4-D toxicity with rhabdomyolysis.
Case Report: In this case study we present a case of intentional consumption of 2, 4-D herbicide with main gastrointestinal complain that became toward rhabdomyolysis and liver damage during hospital course. Successful treatment with sodium bicarbonate and other conservative therapies was performed.
Conclusion: In cases of 2, 4-dichlorophenoxyacetic acid poisoning, rhabdomyolysis should be in mind and an alkaline diuresis can increase herbicide elimination as well as treatment of rhabdomyolysis should be considered.
- 4-Dichlorophenoxyacetic Acid
How to Cite
Dinamarca VM, Hidalgo ME, Cavieres MF. Lack of effects of 2,4-dichlorophen-oxyacetic acid administration on markers of oxidative stress during early pregnancy in mice. Toxicology. 2007;237(1-3):104-10
Azazh A. Case series of 2, 4-D poisoning in Tikur Anbessa Teaching Hospital. Ethiop Med J. 2010;48(3):243-6
Keller T, Skopp G, Wu M, Aderjan R. Fatal overdose of 2, 4-dichlorophenoxyacetic acid (2, 4-D). Forensic Sci Int. 1994;65(1):13-18.
Bradberry SM, Watt BE, Proudfoot AT, Vale JA. Mechanisms of toxicity, clinical features, and management of acute chlorophenoxy herbicide poisoning: a review. J Toxicol Clin Toxicol. 2000;38(2):111-22.
Bhalla A, Suri V, Sharma N, Mahi S, Singh S. 2, 4-D (ethyl ester) poisoning: experience at a tertiary care centre in northern India.Emerg Med J. 2008;25(1):30-2.
Aromataris EC, Astill DS, Rychkov GY, Bryant SH, Bretag AH, Roberts ML, Modulation of the gating of CIC-1 by S-(-) 2-(4-chlorophenoxy) propionic acid, Br J Pharmacol. 1999;126(6):1375-82.
Beasley VR, Arnold EK, Lovell RA, Parker AJ. 2, 4-D toxicosis. I: A pilot study of 2, 4-dichlorophenoxyacetic acid- and dicamba-induced myotonia in experimental dogs, Vet Hum Toxicol 1991;33(5):435-40.
Bradberry SM, Proudfoot AT, Vale JA. Poisoning due to chlorophenoxy herbicides, Toxicol Rev. 2004;23(2):65-73.
Roberts DM, Seneviratne R, Mohammed F, et al. Intentional self-poisoning with the chlorophenoxy herbicide 4-chloro-2-methylphenoxyacetic acid (MCPA), Ann Emerg Med. 2005;46(3):275-84.
Chlorophenoxy herbicides. Recognition and management of pesticide poisonings. In: Reigart, JR.; Roberts, JR., editors. 5 ed. United States Environmental Protection Agency; Washington: 1999. p.94-9.
Friesen EG, Jones GR, Vaughan D. Clinical presentation and management of acute 2, 4-D oral ingestion. Drug Saf. 1990;5(2):155-9.
Vale A. Reducing absorption and increasing elimination. Medicine. 2012;40(2):67-68.
Proudfoot AT, Krenzelok EP, Vale JA, Position Paper on urine alkalinization, J Toxicol Clin Toxicol. 2004;42(1):1-26.
Prescott LF, Park J, Darrien I. Treatment of severe 2,4-D and mecoprop intoxication with alkaline diuresis, Br J Clin Pharmacol. 1979;7(1):111-6.
Bretag AH, Dawe SR, Kerr DI, Moskwa AG. Myotonia as a side effect of diuretic action, Br J Pharmacol. 1980;71(2):467-71.
Duraković Z1, Gasparović V. [Use of extracorporeal circulation in the treatment of 2,4-dichlorophenoxyacetic acid poisoning]. Acta Med Iugosl. 1990;44(1):65-73.
Nakbi A ,Tayeb W, Dabbou S, Chargui I, Issaoui M, et al , Olive oil protects against 2,4-dichlorophenoxyacetic acid-induced oxidative renal dysfunction in adult rats,European Journal of Lipid Science and Technology. 2012;469–478.
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