Premature Centromere Division and Spontaneous Abortion
International Journal of Medical Toxicology and Forensic Medicine,
Vol. 3 No. 2(Spring) (2013),
10 June 2013
,
Page 67-70
https://doi.org/10.22037/ijmtfm.v3i2(Spring).4012
Abstract
Premature Centromere Division (PCD) was observed in the chromosomes of metaphase spreads in a patient with the history of recurrent abortions. Short term leukocyte cultures were set up with blood sample from the woman with a history of recurrent abortions for the past four consequent years. 25 % of the metaphase spreads screened displayed premature centromere division of the chromosomes in each of the cells. This abnormal behavior of the centromeres may predispose the individual to cell division errors due to chromosome instability and the consequences of which may be a spontaneous abortion.- Cell division
- Chromosomes
- Chromatids
- Premature centromere division
- Non-disjunction
- Abortion
How to Cite
References
Margaret J, Jack L, Spurbeck BS. The AGT cytogenetic Laboratory manual 3rd edition. Peripheral blood cytogenetic method: Lymphocyte macro culture.91-93.
Vig BK. Sequence of centromere separation another mechanism for the origin of non-disjunction. Hum Genet. 1984;66:239-243.
Anuradha M. Manjunatha Premature Centromeric Division and Abortions. IJHG. 2001;1(3):191-193.
Madhan K, Lindhout K, Palan A. Premature centromere division PCD: A dominantly inherited cytoxzgenetic anomaly . Hum Gene. 1987;77:193 -196.
Bajnoczky K, Gardo S. Premature anaphase in a couple with recurrent miscarriages Hum Genet. 1993;92:388-390.
Lakshmi Kalpana V, Satyanarayana M, Prabhaker S, Sarvani R. Chromosomal Instability in Recurrent Spontaneous Aborters. Int J Hum Genet. .2004;4(1):31-36 .
Mustaqahmed S, Balachander V, Mohanadevi S. Identification of cytogenetic alterations in infertile couples experiencing repeated spontaneous abortions using Giemsa Trypsin Giemsa banding (GTG). Scientific research and essays. 2011;6(1):182-186.
Gabarrón J, Jimenez A, Glover G. Premature centromere division dominantly inherited in a sub fertile family. Cytogenet Cell Genet. 1986;43:69-71 .
Corona-Rivera A, Salamanca-Gomez F. Cell cycle and centromere FISH studies in premature centromere Division. BMC Medical Genetics. 2005;6:33-37.
Muro Y. Centromere Protein B Assembles Human Centromeric a-satellite DNA at the 17-bp Sequence, CENPB Box. The Journal of Cell Biology. 1992;116:585-596.
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