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  3. Vol. 3 No. 2(Spring) (2013): International Journal of Medical Toxicology and Forensic Medicine
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ISSN: 2251-8762

International Journal of Medical Toxicology and Forensic Medicine
Vol. 3 No. 2(Spring) (2013)

Naltrexone Induced Serotonin Syndrome

  • B Behnoush
  • A Memarian
  • M Teimoory

International Journal of Medical Toxicology and Forensic Medicine, Vol. 3 No. 2(Spring) (2013), , Page 64-66
https://doi.org/10.22037/ijmtfm.v3i2(Spring).3991 Published 3 April 2013

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Abstract

Background: Serotonin syndrome resulted from hyperactivity of serotonin in nervous system and is potentially life threatening. Tramadol is known as one it's causing factors. Administration of Naltrexone is associated with a significant increase in the ratio of 5-HIAA/5-HT and DOPAC/DA in the frontal cortex and dorsal hippocampus respectively. We present a rare case with some signs of serotonin syndrome and withdrawal syndrome which simultaneously use naltrexone, tramadol and benzodiazepine in the realm of opium addiction.

Case Report: A 41 years old man who was admitted due to loss of consciousness and seizure.

In simultaneous usage of naltrexone, tramadol and benzodiazepine in an addicted person, and in the case of sever agitation which was resistance to routine treatments, serotonin syndrome beside withdrawal syndrome should be considered and its treatment should be done as soon as possible.

Conclusion: In simultaneous usage of naltrexone, tramadol and benzodiazepine in an addicted person, and in the case of sever agitation which was resistance to routine treatments, serotonin syndrome beside withdrawal syndrome should be considered and its treatment should be done as soon as possible.

Keywords:
  • Naltrexone
  • Serotonin Syndrome
  • Tramadol
  • Seizure
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How to Cite

Behnoush, B., Memarian, A., & Teimoory, M. (2013). Naltrexone Induced Serotonin Syndrome. International Journal of Medical Toxicology and Forensic Medicine, 3(2(Spring), 64-66. https://doi.org/10.22037/ijmtfm.v3i2(Spring).3991
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References

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Ables A. Prevention diagnosis and management of serotonin syndrome. American family physician j. 2010;81(9):1139-1141.

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Isenberg D, Wong SC, Curtis JA. Serotonin syndrome triggered by a single dose of suboxone. Am J Emerg Med. 2008;26(7):840:3-5.

eHealthMe-Real World Drug Outcomes. http://www.ehealthme.com

Hoffman R, Nelson L, Howland M, et all. Goldfranks manual of Toxicologic Emergencies. New York: McGraw-Hill companies. 2007;607-559.

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   International Journal of Medical Toxicology and Forensic Medicine (IJMTFM)

                                                  Print ISSN: 2251-8762

                                                     Online ISSN: 2251-8770

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