Naltrexone Induced Serotonin Syndrome
International Journal of Medical Toxicology and Forensic Medicine,
Vol. 3 No. 2(Spring) (2013),
Background: Serotonin syndrome resulted from hyperactivity of serotonin in nervous system and is potentially life threatening. Tramadol is known as one it's causing factors. Administration of Naltrexone is associated with a significant increase in the ratio of 5-HIAA/5-HT and DOPAC/DA in the frontal cortex and dorsal hippocampus respectively. We present a rare case with some signs of serotonin syndrome and withdrawal syndrome which simultaneously use naltrexone, tramadol and benzodiazepine in the realm of opium addiction.
Case Report: A 41 years old man who was admitted due to loss of consciousness and seizure.
In simultaneous usage of naltrexone, tramadol and benzodiazepine in an addicted person, and in the case of sever agitation which was resistance to routine treatments, serotonin syndrome beside withdrawal syndrome should be considered and its treatment should be done as soon as possible.
Conclusion: In simultaneous usage of naltrexone, tramadol and benzodiazepine in an addicted person, and in the case of sever agitation which was resistance to routine treatments, serotonin syndrome beside withdrawal syndrome should be considered and its treatment should be done as soon as possible.
- Serotonin Syndrome
How to Cite
Takeshita J. Serotonin syndrome associated with tramadol. prim care companion J clin psychiatry. 2009;11(5):173.
Frank CH. Recognition and treatment of serotonin syndrome. MFC J. 2008;54(7):988-992.
Sanson R. Tramadol. Psychiatry (Edgmont) j. 2009;6(4):17-21.
Ables A. Prevention diagnosis and management of serotonin syndrome. American family physician j. 2010;81(9):1139-1141.
Dimatelis J, Russell VA. The effects of lobe line and naltrexone on methamphetamine-induced place preference and striatal dopamine and serotonin levels in adolescent rats with a history of maternal separation. Springer for Research & Development. 27(3): 351-361.
Sharma TR, Chan WC, Gintzler AR. Effect of chronic naltrexone administration and its withdrawal on the regional activity of neurons that contain norepinephrine, dopamine and serotonin. Brain Res. 1988;442(2):379-86.
Isenberg D, Wong SC, Curtis JA. Serotonin syndrome triggered by a single dose of suboxone. Am J Emerg Med. 2008;26(7):840:3-5.
eHealthMe-Real World Drug Outcomes. http://www.ehealthme.com
Hoffman R, Nelson L, Howland M, et all. Goldfranks manual of Toxicologic Emergencies. New York: McGraw-Hill companies. 2007;607-559.
- Abstract Viewed: 4640 times
- PDF Downloaded: 1225 times