Comparison of Activated Charcoal and Industrial Charcoal in Prevention of GI Absorption of Diazepam
International Journal of Medical Toxicology and Forensic Medicine,
Vol. 2 No. 4(Autumn) (2012),
21 March 2013
,
Page 124-127
https://doi.org/10.22037/ijmtfm.v2i4(Autumn).3865
Abstract
B
Background: GI decontamination is required frequently in management of intoxicated patients. Activated charcoal is used for this purpose normally. Is it possible that powdered industrial charcoal is used as a substitute? Present study was conducted to determine efficiency of industrial charcoal in prevention of absorption of diazepam, compared to activated charcoal.
Method: 30 Sprague–dawley rats were randomly divided into 3 equal groups. 20 mg/kg diazepam was given orally to all 3 groups. No GI decontamination was performed for the control group. Activated and industrial charcoal (1 g/kg dissolved in 10 ml of water) was administered for other two groups. The urinary concentration of diazepam was used for evaluation of level of the drug absorption in the animals.
Results: The mean urine concentration of diazepam was considerably lower in groups taking charcoal, compared control group. However the concentration in the group taking activated charcoal was lower than the concentration in the group taking industrial charcoal.
Conclusion: Results of present study suggest that industrial charcoal can be used as a substitute for activated charcoal, though with a little lower efficacy for absorption of drugs and toxins.
- Activated Charcoal
- Antidote
- Animal Model
- Poisoning
- Therapy
How to Cite
References
Moghadam M, Abdollahi M. Acute poisoning in Babol during 1994-1996. JBUMS. 1998;1(1):19-26.
Ghoreishi SA, Mousavinasab N. Systematic review of researches on suicide and suicide attempt in Iran. Iranian Journal of Psychiatry and Clinical Psychology. 2008;14:115-121.
Mousavi A, Khosravi A, Hasani MH, Jahani Z. The epidemiologic study of deliberate self-harm (poisoning) in Shahroud. Knowledge and health Journal. 2007;2(2):39-45.
Karami M, Ebrahimzadeh MA, Yousefi P, Khani K. Investigation of Drug poisoning effects in Boo-Ali and Nileh-Shaban Hospitals during 2000-2002. Razi journal of Medical sciences. 2005;11(42):629-636.
Yasemi MT, Saneie N, Malekpur Afshar R, Honarmand AR, Mirshekari R. Epidemiological evaluation of suicide in Kerman. Andeesheh va Raftar. 1998;3(12):15-27.
Diazepam. PubChem. National Institute of Health: National Library of Medicine. 2006.
Using charcoal efficiently". http://www.fao.org/docrep/X5328E /x5328e0b.htm. Retrieved 2010-02-01.
Lapatto O, Kivisto K.T, Neavonen J. Effect of activated charcoal alone or given after gastric lavage in reducing the absorption of diazepam, ibuprofen and citalopram. 1999;48:148-153.
Katona BG, Siegel EG, Cluxton RJ Jr. The new black magic: activated charcoal and new therapeutic uses. J Emerg Med. 1987;5(1):9-18.
Barbeque – History of Barbecue". Inventors.about.com. 2010-06-15.
Isbister GK, Kumar VV. Indications for single-dose activated charcoal administration in acute overdose. Curr Opin Crit Care. 2011;17(4):351-7.
Bond GR. The role of activated charcoal and gastric emptying in gastrointestinal decontamination: a state-of-the-art review. Ann Emerg Med. 2002;39(3):273-86.
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