Physiology and Anatomy of Hair in Drug Abusing Cases
International Journal of Medical Toxicology and Forensic Medicine,
Vol. 2 No. 4(Autumn) (2012),
21 March 2013
,
Page 153-159
https://doi.org/10.22037/ijmtfm.v2i4(Autumn).3765
Abstract
To interpret the results of hair analysis tests accurately and to understand the appropriate role of hair analysis in drug abuse testing and solve instances of poisoning, drug and substance abuse, a basic knowledge of the biology of hair is essential. In case of poising by heavy metals, the hair retains traces of poison for a considerable period. Chemical examination of hair in such cases will reveal the presence of poison in the living as well as exhumed whose biology is only partially understood. Hair grows from small organs (follicles-a skin organ which produce hair) located within the complex microenvironment of the skin which has multiple layers of tissue, three glands whose secretions bathe hair, and multiple vascular systems which are capable of transferring drugs to hair at many levels along the path of the hair shaft. The advantages and disadvantages of using pubic, scalp and beard hair as specimens for hair analysis are also considered. A more precise understanding of the mechanisms involved in the incorporation of drugs into hair is critical for forensic scientist in order to interpret the results of hair analysis properly.
- Human Hair
- Hair Follicle
- Forensic Investigation
- Drug Abuse
How to Cite
References
Montaga W, Ellis RA. The biology of hair growth, Academic Press, New York, 1958.
Volkovic V. Human hair: fundamental and methods for measurements of elemental composition, Vol.1, CRC Press, Boca Raton, FL, 1988.
Stenn KS, Messenger AG, Baden HP. The molecular and structural biology of hair. Ann. N.Y. Acad. Sci. 1991;642.
Robbins CR. Chemical and physical behavior of human hair, springer-verlag, New York; 1988.
Montagna W, Vann Scott EJ. The anatomy of hair follicle, Academic Press, New York.1958;39-64.
Hoops HC. The biologic basis for using hair and nails for the analysis of trace elements. Sci. Total Environ. 1997;7:71-89.
Caruthers C. Biochemistry of the skin and diseade, Charls C. Thomas, Springfield, IL, 1962.
Stowe CM, Plaa GL. Extra renal excreation of drugs and chemicals. Annu. Rev. Pharmacol. 1968;8:344-46.
Wojciech R, Michael W, Kaye I. Histology: a text and atlas: with cell and molecular biology. Hagerstown, Maryland: Lippincott Williams & Wilkins. 2003.
Yang EN, Lee ST. A review: the location, molecular characterization and multipotency of hair follicle epidermal stem cells. Ann. Acad. Med. Singap. 2004;33(6):784–88.
Stenn KS, Paus R. Controls of Hair Follicle Cycling. Physiological Reviews. 2001;81(1):449–94.
Lavker RM. Hair follicle stem cells. J. Invest. Dermatol. Symp. 2003;8:28-38.
Ryder ML. Nutritional factors influencing hair and wool growth. Academic Press, New York.1958;305-34.
Bern HA, Harknesss DR, Blair SM. Radiographic studies of keratin formation, proc. nat. Acad. Sci. U.S.A. 1955;41:55-60.
Muller-Rover S, Handjiski B, van der Veen C, Eichmuller S, Foitzik K, McKay IA, Stenn K, Paus R. A comprehensive guide for the accurate classification of murine hair follicles in distinct hair cycle stages. J. Invest. Dermatol. 2001;117:3-15.
Alonso L, Fuchs E. The hair cycle. Journal of Cell Science. 119:391-93.
Paus R, Cotsarelis G. The biology of hair follicles. N. Engl. J. Med. 1999;341(7):491–7.
Ralf P, Cotsarelis G. The Biology of Hair Follicles. The New England Journal of Medicine. 1999;341(7):491-97.
Giovanoli-Jkubczak T, Berg GC, measurement of mercury in human hair. Arch. Environ. Heath. 1974;24:139-44.
Meyers RJ, Hamilton JB. Regeneration and rate of growth of hairs in man. Ann. N.Y. Acad. Sci. 1951;53:562-68.
Saitoh M, Uzuka M, Sakamoto M, Kobori T. Rate of hair growth. Pergamon Press, Oxford. 1969;183-01.
Bisbing R, in Saferstein, editor, forensic science handbook, Prentice hall, 2002;2(1).
Chatt A, Katz A. Hair analysis. Application in biomedical and environment sciences, VCH Publishers, New York, 1988.
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