International Journal of Medical Toxicology and Forensic Medicine

Abstract

Background: Bronchial asthma (BA) is a chronic airway disease. Its prevalence has been increased in a few past decades. The role of trace elements of zinc, magnesium and calcium have evaluated on the pathophysiology of asthma in the early decades. The purpose of present study was to assess status of zinc, magnesium and calcium in serum of patients with chronic bronchial asthma in Tehran. Material and methods: Patients with chronic persistent asthma enrolled sequentially based on the GINA guideline. Zinc, magnesium and calcium in serum measured with the recommendation's manufacturer protocols. Results: A total of 137 subjects participated in the present study. Of them, females were 58.4%and males 41.6%. The mean age was 33.77 ± 8.33 SD years. The frequency of zinc, magnesium and calcium deficiency detected 10.2%, 8%, 5.8%, respectively. Conclusion: Hypozincemia hypomagnesemia and hypocalcemia found in selected patients with stable chronic persistent asthma. Noticeable of entire current trace elements deficiency observed in the female sex.  However, significant differences of Ca deficiency between genders revealed effects of sex on the calcium homeostasis. Detection and improvement of trace elements, and electrolyte abnormalities should be beneficial in the outcome of asthma management.