Beyond Pain Relief: Exploring the Hidden Renal Consequences of NSAID Therapy
International Journal of Medical Toxicology and Forensic Medicine,
Vol. 16 (2026),
1 January 2026
https://doi.org/10.22037/ijmtfm.v16.53396
Abstract
Background: Older adults are especially vulnerable to peptic ulcers, gastrointestinal irritation, and fluid retention caused by non-steroidal anti-inflammatory drugs (NSAIDs). It is common to inappropriately prescribe NSAIDs for osteoarthritis before adequately addressing physical and functional interventions along with oral paracetamol. If an NSAID is necessary as a supplementary treatment, it should be administered at the lowest effective dosage. Ibuprofen is likely the preferred NSAID for reducing gastrointestinal side effects. A proton pump inhibitor should be considered to prevent upper gastrointestinal complications in individuals at higher risk.
Methods: NSAIDs can also lead to sodium and water retention, increased blood pressure, hyperkalemia, and swelling. Frequent or severe instances of kidney damage can lead to a gradual decline in kidney function, particularly in at-risk patients. Identifying risk factors and avoiding unnecessary long-term use of NSAIDs is essential.
Results: Additionally, it helps with dysmenorrhea. It is a reversible cyclooxygenase inhibitor sold over the counter in the UK and many other countries. At normal dosages, it causes less gastric irritation than aspirin and other NSAIDs. Children can use a suspension.
Conclusion: NSAID-related side effects include reversible renal impairment in elderly patients or those with cirrhosis, nephrotic syndrome, or heart failure. By preventing formation, it lessens the effectiveness of diuretics and antihypertensive drugs.
- Cyclooxygenase, Prostaglandins, NSAIDs
How to Cite
References
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