The Potential effects of sodium bromide, calcium carbonate, and potassium nitrate against aluminum phosphide poisoning in the heart and lung tissues of rats: focus on oxidative stress
International Journal of Medical Toxicology and Forensic Medicine,
Vol. 15 No. 03 (2025),
22 Shahrivar 2025
,
Page 1-11
https://doi.org/10.22037/ijmtfm.v15i03.47458
Abstract
Background: Aluminum phosphide (AlP) exposure can cause fatal poisoning due to severe oxidative damage. The current study evaluated the effects of sodium bromide (NaBr), calcium carbonate (CaCO3), and potassium nitrate (KNO3) on ALP-induced cardiac and lung injuries and determined the oxidative stress markers.
Methods: Sixty-six male Wistar rats were allocated into 11 groups: Normal control, ALP group (40 mg/kg body weight AlP was administered by oral gavage), ALP + Low dose of CaCo3, ALP + High dose of CaCo3, ALP + Low dose of KNO3, ALP + High dose of KNO3, ALP + Low dose of NaBr, ALP + High dose of NaBr, High dose of CaCO3, High dose of KNO3, and high dose of NaBr.
Results: Administration of CaCO3 and NaBr reduced ALT, MDA, and SOD levels and increased TAC levels in the serum and lung tissue.
Conclusion: CaCO3 and NaBr may be promising and potential options for managing and treating AlP toxicity.
How to Cite
References
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