Demographic and Clinical Characteristics of Patients Who Died of Methanol Toxicity During COVID 19 Period in Loghman-e Hakim Hospital in Tehran
International Journal of Medical Toxicology and Forensic Medicine,
20 September 2021
Background: Outbreaks of methanol poisoning were observed during the Covid 19 pandemic. Acute methanol poisoning is a global crisis. Methanol can cause acute and fatal toxicity through metabolic acidosis. In the present study, we evaluate demographic, clinical, and paraclinical characteristics of patients who died in the recent outbreak of methanol poisoning in Tehran in March and April 2020.
Methods: This is a cross-sectional study that was accomplished at the Loghman-Hakim Hospital in Tehran that performed on 80 patients who died of methanol toxicity; demographic, clinical, and laboratory data were collected retrospectively from the patient’s files and analyzed with appropriate statistical tests.
Results: Men were significantly more involved than women %85 vs. %15. There were no significant differences between other characteristics of male and female patients, including time between consumption to arrive hospital, dialysis sessions, pulse rate, respiratory rate, loss of consciousness, seizure, acute kidney injury, brain C.T. and ICH (intracerebral hemorrhage). BS (blood sugar) and liver function tests and serum potassium were higher than average in most of the patients.
Discussion and conclusion: Our study shows this outbreak of methanol poisoning was due to the use of alcoholic drinks that contain methanol. Men were primarily affected that could be because of the cultural and social status of our country. The greater seizure probability in females could be because of enhancing the NMDA receptor by estrogen. Abnormality in ALT (alanine aminotransferase), AST (aspartate aminotransferase), and PT (prothrombin time) was seen in most patients, indicating liver damage. Misbeliefs about the protective effects of alcohol consumption against COVID-19 may lead many to consume poorly made alcohols that contain methanol and outbreaks of methanol intoxication.
- Methanol Toxicity
- Metabolic Acidosis
- Formic acid
How to Cite
2. Divekar, M., et al., Acute methanol poisoning: Report on a recent outbreak in Maharashtra. J Assoc Phys India, 1974. 22: p. 477-83.
3. Kumar, M., et al., Single center experience of managing methanol poisoning in the hilly state of uttarakhand: A cross sectional study. International journal of critical illness and injury science, 2019. 9(4): p. 172.
4. Poisoning, A.A.o.C.T.A.H.C.o.t.T.G.f.M., et al., American Academy of Clinical Toxicology practice guidelines on the treatment of methanol poisoning. Journal of toxicology: Clinical toxicology, 2002. 40(4): p. 415-446.
5. Doreen, B., et al., Fatal methanol poisoning caused by drinking adulterated locally distilled alcohol: Wakiso District, Uganda, June 2017. Journal of environmental and public health, 2020. 2020.
6. Kerns, W., et al., Formate kinetics in methanol poisoning. Journal of Toxicology: Clinical Toxicology, 2002. 40(2): p. 137-143.
7. McMartin, K., D. Jacobsen, and K.E. Hovda, Antidotes for poisoning by alcohols that form toxic metabolites. British journal of clinical pharmacology, 2016. 81(3): p. 505-515.
8. Sivilotti, M., et al., Reversal of severe methanol-induced visual impairment: no evidence of retinal toxicity due to fomepizole. Journal of Toxicology: Clinical Toxicology, 2001. 39(6): p. 627-631.
9. Chick, J., Alcohol and COVID-19. Alcohol and Alcoholism (Oxford, Oxfordshire), 2020.
10. Arasteh, P., M. Pakfetrat, and J. Roozbeh, A surge in methanol poisoning amid CoViD-19 pandemic: why is this occurring? The American Journal of the Medical Sciences, 2020. 360(2): p. 201.
11. Banagozar Mohammadi, A. and M. Delirrad, Problems with methanol poisoning outbreaks in Iran. Alcohol and alcoholism, 2019.
12. Chegeni, M., et al., Alcohol consumption in Iran: A systematic review and meta‐analysis of the literature. 2020.
13. Hovda, K.E., et al., Methanol outbreak in Norway 2002–2004: epidemiology, clinical features and prognostic signs. 2005. 258(2): p. 181-190.
14. Paasma, R., et al., Methanol mass poisoning in Estonia: outbreak in 154 patients. 2007. 45(2): p. 152-157.
15. Zakharov, S., et al., Czech mass methanol outbreak 2012: epidemiology, challenges and clinical features. 2014. 52(10): p. 1013-1024.
16. Mostafazadeh, B. and H.J.A.P.J.o.M.T. Eghbali, An Epidemiologic Study on Methyl Alcohol Poisoning in Tehran, Iran. 2014. 3(Supplement 1): p. 8-8.
17. Morteza Bagi, H.R., et al., Epidemiology of alcohol poisoning and its outcome in the north-west of Iran. 2015. 3(1): p. 27-32.
18. Shokoohi, M., et al., A Syndemic of COVID-19 and methanol poisoning in Iran: Time for Iran to consider alcohol use as a public health challenge? 2020.
19. Singleton, A.J.I.J.o.M.s.H., " It's Because of the Invincibility Thing": Young Men, Masculinity, and Testicular Cancer. 2008. 7(1).
20. O'Connor, S.E., M.L.J.T.J.o.P.P. Zupanc, and Therapeutics, Women and epilepsy. 2009. 14(4): p. 212-220.
21. Sanaei-Zadeh, H., et al., Hyperglycemia is a strong prognostic factor of lethality in methanol poisoning. 2011. 7(3): p. 189-194.
22. Shokoohi, M., et al., A syndemic of COVID-19 and methanol poisoning in Iran: Time for Iran to consider alcohol use as a public health challenge? 2020, Elsevier.
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