Hypoglycemia in Patients With Pure Benzodiazepine Poisoning Hypoglycemia in patients with pure benzodiazepine poisoning
International Journal of Medical Toxicology and Forensic Medicine,
Vol. 11 No. 2 (2021),
15 June 2021
,
Page 32702
https://doi.org/10.32598/ijmtfm.v11i2.32702
Abstract
Background: Various studies investigated the effects of benzodiazepines on insulin and blood glucose levels and provided contradictory results. The present study aimed to evaluate the clinical effects of benzodiazepine poisoning on hypoglycemia.
Methods: This retrospective cross-sectional study (from 22/June/2018 to 22/December/2018) was conducted on all medical records of adult patients with benzodiazepine poisoning who were referred to Ali-Asghar Hospital. The required data were collected using a data-gathering form and then analyzed.
Results: In total, 61 patients were enrolled in this study. Furthermore, 19 (31.2%) patients developed hypoglycemia. Besides, 50 (82%) patients used benzodiazepine for a suicide attempt, i.e. higher in patients with hypoglycemia (P<0.0001). Multivariate logistic regression test data indicated that benzodiazepine consumption for suicide attempt (OR=47.978, P=0.001, 95%CI, 5.313-433.277), and the respiratory rate at the time of suicide (OR=0.549, P=0.023, 95%CI, 0.328-0.920) were predictive factors for hypoglycemia in patients with benzodiazepine poisoning.
Conclusion: Our study data suggested that 31% of patients who were poisoned with benzodiazepines developed hypoglycemia. The suicidal use of drugs and respiratory rates were predictive factors for hypoglycemia in these patients.
- Benzodiazepines, Hypoglycemia, Toxicity
How to Cite
References
2. Kang M, Galuska MA, Ghassemzadeh S. Benzodiazepine Toxicity. [Updated 2020 Jul 1]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2020 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK482238/
3. Gramaglia E, Ramella Gigliardi V, Olivetti I, Tomelini M, Belcastro S, Calvi E, et al. Impact of short-term treatment with benzodiazepines and imidazopyridines on glucose metabolism in healthy subjects. J Endocrinol Invest. 2014;37(2):203-6. doi: 10.1007/s40618-013-0016-y.
4. Geulayov G, Ferrey A, Casey D, Wells C, Fuller A, Bankhead C, et al. Relative toxicity of benzodiazepines and hypnotics commonly used for self-poisoning: An epidemiological study of fatal toxicity and case fatality. J Psychopharmacol. 2018;32(6):654-62. doi: 10.1177/0269881118754734.
5. Mohseni G, Ranjbar A, Rezaei M. Oral diazepam effect on surgical patient’s postoperative blood sugar. Ann Biol Res. 2012;3(2):382-.5
6. Schaira VR, Ranali J, Saad MJ, de Oliveira PC, Ambrosano GM, Volpato MC. Influence of diazepam on blood glucose levels in nondiabetic and non-insulin-dependent diabetic subjects under dental treatment with local anesthesia. Anesth Prog. 2004;51(1):14-8. PMID: 15106685.
7. Nzor JN, Uwakwe AA, Onuoha SC. Impact of benzodiazepines administration on selected biochemical parameters of albino Wistar rats (Rattus rattus). Egyptian Pharmaceutical Journal. 2018;17(1):40. doi: 10.4103/epj.epj_26_17.
8. Afkhami Ardekani M, Shojaoddini Ardekani A, Soltani V, Molanoori E. Comparing the effects of Fluoxetine and Alprazolam on blood glucose in patients with type 2 diabetes. J Qazvin Univ Med Sci. 2008; 12 (1):21-9.
9. Perlmuter LC, Flanagan BP, Shah PH, Singh SP. Glycemic control and hypoglycemia: is the loser the winner? Diabetes Care. 2008;31(10):2072-6. doi: 10.2337/dc08-1441.
10. Lin CL, Yeh MC, Harnod T, Lin CL, Kao CH. Risk of Type 2 Diabetes in Patients With Nonapnea Sleep Disorders in Using Different Types of Hypnotics: A Population-Based Retrospective Cohort Study. Medicine (Baltimore). 2015;94(38):e1621. doi: 10.1097/MD.0000000000001621.
11. Moghadamnia AA, Moudi S, Tamaskani N, Saleki M, Hamidia A, Mouodi M, Bijani A. Effects of Alprazolam and Clonazepam on Blood Sugar in Patients with Panic Disorder. Cyprus J of Med Sci. 2019;4 (3):195-200. doi: 10.5152/cjms.2019.716.
12. Giordano R, Grottoli S, Brossa P, Pellegrino M, Destefanis S, Lanfranco F, et al. Alprazolam (a benzodiazepine activating GABA receptor) reduces the neuroendocrine responses to insulin-induced hypoglycaemia in humans. Clin Endocrinol (Oxf). 2003;59(3):314-20. doi: 10.1046/j.1365-2265.2003.01847.x.
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