Assessment of Risk Factors and the Effect of Drug Abuse on the Incidence of Ischemic Heart Disease in Patients Less Than 40 Years Old
International Journal of Medical Toxicology and Forensic Medicine,
Vol. 11 No. 1 (2021),
23 January 2021
Background: in this study, we examined the risk factors and the effects of substance abuse on the incidence of ischemic heart disease in patients less than 40 years old in Shahid Rajaei Hospital in Karaj from 2019-2020.
Methods: This case-control study was done on 70 patients in the cases and 70 cases in the control groups. All demographic data, including age, gender, place of residence, weight, height, body mass index, cardiovascular (CVD) risk factors, including hypertension, high levels of blood fats, diabetes, a history of smoking cigarettes, tobacco, crystal meth, and cocaine, alcohol consumption, as well as a history of taking supplements for bodybuilding, and sex-enhancing drugs were obtained. Afterward, blood levels of glucose and fats were evaluated and urine analysis for the presence of drugs, such as amphetamine, methamphetamine, buprenorphine, benzodiazepines, cannabinoids, cocaine, morphine, methadone, tramadol, and tricyclic antidepressants (TCA) was done. SPSS software v. 22 was used for data analysis.
Results: Among the studied underlying factors and drugs, family history, high blood pressure, diabetes, smoking, and low-density lipoprotein (LDL) levels above 130 mg/dL were significantly associated with a higher risk of acute myocardial infarction (MI) (P<0.05). Interestingly, alcohol consumption and the use of tobacco, opium, methadone, heroin, cocaine, cannabis, amphetamines, methamphetamine, tramadol, benzodiazepines, TCA, buprenorphine, and anabolic steroids were not significantly associated with acute MI under 40 years (P>0.05).
Conclusion: according to the results of the present study, it seems that a positive family history of MI under the age of 55, hypertension, diabetes, smoking, and LDL levels above 130 mg/dL are more significant risk factors for acute MI in patients under 40 years of age in comparison with the consumption of alcohol and the use of hookah, opium, methadone, heroin, cocaine, cannabis, amphetamine, methamphetamine, tramadol, benzodiazepines, TCA, buprenorphine, and anabolic steroids. It should be noted that further studies in this area are recommended.
- Myocardial infarction
- Cardiovascular Disease
How to Cite
Tsai WC, Wu KY, Lin GM, Chen SJ, Lin WS, Yang SP, et al. Clinical characteristics of patients less than forty years old with coronary artery disease in Taiwan: A cross-sectional study. Acta Cardiol Sin. 2017; 33(3):233-40. [DOI:10.1161/01.CIR.95.1.5]
Mohseni J, Kazemi T, Maleki MH, Beydokhti H. A systematic review on the prevalence of acute myocardial infarction in Iran. Heart Views. 2017; 18(4):125-32. [DOI:10.4103/HEARTVIEWS.HEARTVIEWS_71_17] [PMID] [PMCID]
Selwyn AP, Kinlay S, Libby P, Ganz P. Atherogenic lipids, vascular dysfunction, and clinical signs of ischemic heart disease. Circulation. 1997; 95(1):5-7. [DOI:10.1161/01.CIR.95.1.5] [PMID]
Christoffersen M, Frikke-Schmidt R, Schnohr P, Jensen GB, Nordestgaard BG, Tybjærg-Hansen A. Visible age-related signs and risk of ischemic heart disease in the general population: A prospective cohort study. Circulation. 2014; 129(9):990-8. [DOI:10.1161/CIRCULATIONAHA.113.001696] [PMID]
Egred M, Viswanathan G, Davis GK. Myocardial infarction in young adults. Postgrad Med J. 2005; 81(962):741-5. [DOI:10.1136/pgmj.2004.027532] [PMID] [PMCID]
Vedanthan R, Seligman B, Fuster V. Global perspective on acute coronary syndrome: A burden on the young and poor. Circ Res. 2014; 114(12):1959-75. [DOI:10.1161/CIRCRESAHA.114.302782] [PMID] [PMCID]
Moran AE, Forouzanfar MH, Roth GA, Mensah GA, Ezzati M, Murray CJ, et al. Temporal trends in ischemic heart disease mortality in 21 world regions, 1980 to 2010: The global burden of disease 2010 study. Circulation. 2014; 129(14):1483-92. [DOI:10.1161/CIRCULATIONAHA.113.004042] [PMID] [PMCID]
Hoo FK, Foo YL, Lim SM, Ching SM, Boo YL. Acute coronary syndrome in young adults from a Malaysian tertiary care centre. Pak J Med Sci. 2016; 32(4):841-5. [DOI:10.12669/pjms.324.9689] [PMID] [PMCID]
Magnusson BJ, Agnarsson U, Guðnason T, Þorgeirsson G. [Acute myocardial infarction among Icelanders forty years old and younger 2005-2009. Comparison with a study carried out 1980-1984 (Icelandic)]. Laeknabladid. 2017; 103(1):11-5. [DOI:10.17992/lbl.2017.01.115] [PMID]
Deora S, Kumar T, Ramalingam R, Nanjappa Manjunath C. Demographic and angiographic profile in premature cases of acute coronary syndrome: Analysis of 820 young patients from South India. Cardiovascular Diagn Ther. 2016; 6(3):193-8. [DOI:10.21037/cdt.2016.03.05] [PMID] [PMCID]
Tini G, Proietti G, Casenghi M, Colopi M, Bontempi K, Autore C, et al. Long-term outcome of acute coronary syndromes in young patients. High Blood Press Cardiovasc Prev. 2017; 24(1):77-84. [DOI:10.1007/s40292-017-0183-6] [PMID]
Vanberg P, Atar D. Androgenic anabolic steroid abuse and the cardiovascular system. Handb Exp Pharmacol. 2010; (195):411-57. [DOI:10.1007/978-3-540-79088-4_18] [PMID]
Rezkalla S, Kloner RA. Cardiovascular effects of marijuana. Trends Cardiovascular Med. 2019; 29(7):403-7. [DOI:10.1016/j.tcm.2018.11.004] [PMID]
Khodneva Y, Muntner P, Kertesz S, Kissela B, Safford MM. Prescription opioid use and risk of coronary heart disease, stroke, and cardiovascular death among adults from a prospective cohort (REGARDS Study). Pain Med. 2016; 17(3):444-55. [DOI:10.1111/pme.12916] [PMID] [PMCID]
Kadhum M, Jaffery A, Haq A, Bacon J, Madden B. Measuring the acute cardiovascular effects of shisha smoking: A cross-sectional study. JRSM Open. 2014; 5(6):2054270414531127. [DOI:10.1177/2054270414531127] [PMID] [PMCID]
Sayyah M, Shirbandi K, Javanmardi F, Rahim F. A systematic review and meta-analysis of the prevalence of methamphetamine abuse in Iranian high school students. J Med Life. 2018; 11(4):262-8. [DOI:10.1111/joim.12035] [PMID]
Kaye S, McKetin R, Duflou J, Darke S. Methamphetamine and cardiovascular pathology: A review of the evidence. Addiction. 2007; 102(8):1204-11. [DOI:10.1111/j.1360-0443.2007.01874.x] [PMID]
Piano MR. Alcohol’s effects on the cardiovascular system. Alcohol Res. 2017; 38(2):219-41. [PMID] [PMCID]
Fauci SA, Longo DA, Kasper DL, Jameson JL, Loscalzo L, Hauser SL. Harrison's Principles of Internal Medicine 20/E (Vol.1 & Vol.2) (ebook). 20th ed. New York: McGraw-Hill Education; 2018. https://www.google.com/books/edition/Harrison_s_Principles_of_Internal_Medici/ID5lDwAAQBAJ?hl=en
Li L, Setoguchi S, Cabral H, Jick S. Opioid use for noncancer pain and risk of myocardial infarction amongst adults. J Intern Med. 2013; 273(5):511-26. [DOI:10.1111/joim.12035] [PMID]
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