Examining Metabolic Profiles in Opioid-Dependent Patient
International Journal of Medical Toxicology and Forensic Medicine,
Vol. 10 No. 3 (2020),
27 September 2020
Background: Drug abuse is a social burden and a public health disorder. Previous evidence
suggested numerous illicit substances (e.g., opioids, amphetamines, cocaine, & cannabis)
affect immune system functions, oxidative stress mechanisms, inflammatory cytokines, and
reactive oxygen species production.
This study aimed to determine the extent of these metabolic parameters in opioid-dependent
patients. We also compared these patients with a healthy control group.
Methods: This study was conducted in Amirie Clinic, Kashan, Iran. Plasma and serum
samples from 50 illicit opioid users (study group) and 50 non-opioid users (control group)
were studied. Metabolic levels for MDA, NO, TAC, GSH, Insulin, HOMA-IR, and hs-CRP
were assessed in both research groups (N=100).
Results: There was a significant difference in the status of MDA (P=0.003), NO (P=0.01), TAC
(P=0.003), GSH (P=0.001), insulin (P=0.04), HOMA-IR (P=0.02), and hs-CRP (P=0.001)
between the study and control groups. Furthermore, there was a significant correlation among
the duration of illicit opioid use and MDA concentrations (r=-0.424, P=0.002), as well as TAC
levels (r=0.314, P=0.02).
Conclusion: The study results suggested metabolic profiles were impaired in the study group,
compared to the controls.
- Metabolic profiles, Opioid, Inflammation, Oxidative stress
How to Cite
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