Examining Metabolic Profiles in Opioid-Dependent Patient
International Journal of Medical Toxicology and Forensic Medicine,
Vol. 10 No. 3 (2020),
27 September 2020
,
Page 28681
https://doi.org/10.32598/ijmtfm.v10i3.28681
Abstract
Background: Drug abuse is a social burden and a public health disorder. Previous evidence
suggested numerous illicit substances (e.g., opioids, amphetamines, cocaine, & cannabis)
affect immune system functions, oxidative stress mechanisms, inflammatory cytokines, and
reactive oxygen species production.
This study aimed to determine the extent of these metabolic parameters in opioid-dependent
patients. We also compared these patients with a healthy control group.
Methods: This study was conducted in Amirie Clinic, Kashan, Iran. Plasma and serum
samples from 50 illicit opioid users (study group) and 50 non-opioid users (control group)
were studied. Metabolic levels for MDA, NO, TAC, GSH, Insulin, HOMA-IR, and hs-CRP
were assessed in both research groups (N=100).
Results: There was a significant difference in the status of MDA (P=0.003), NO (P=0.01), TAC
(P=0.003), GSH (P=0.001), insulin (P=0.04), HOMA-IR (P=0.02), and hs-CRP (P=0.001)
between the study and control groups. Furthermore, there was a significant correlation among
the duration of illicit opioid use and MDA concentrations (r=-0.424, P=0.002), as well as TAC
levels (r=0.314, P=0.02).
Conclusion: The study results suggested metabolic profiles were impaired in the study group,
compared to the controls.
- Metabolic profiles, Opioid, Inflammation, Oxidative stress
How to Cite
References
Amin-Esmaeili, M., et al., Epidemiology of illicit drug use disorders in Iran: prevalence, correlates, comorbidity and service utilization results from the Iranian Mental Health Survey. Addiction, 2016. 111(10): p. 1836-47.
Mehrjerdi, Z.A., et al., Methamphetamine use among Iranian heroin kerack-dependent women: implications for treatment. International journal of high risk behaviors & addiction, 2013. 2(1): p. 15.
Amin-Esmaeili, M., et al., Alcohol use disorders in Iran: Prevalence, symptoms, correlates, and comorbidity. Drug Alcohol Depend, 2017. 176: p. 48-54.
Momtazi, S., A. Noroozi, and R.A. Rawson, An overview of Iran drug treatment and harm reduction programs. Textbook of Addiction Treatment: International Perspectives, 2015: p. 543-554.
Majdzadeh, R., et al., Opium consumption and the risk of traffic injuries in regular users: a case-crossover study in an emergency department. Traffic Inj Prev, 2009. 10(4): p. 325-9.
Tai, B., A.J. Saxon, and W. Ling, Medication-assisted therapy for opioid addiction. Journal of food and drug analysis, 2013. 21(4): p. S13-S15.
Alberti, K.G.M.M., P. Zimmet, and J. Shaw, Metabolic syndrome—a new world‐wide definition. A consensus statement from the international diabetes federation. Diabetic medicine, 2006. 23(5): p. 469-480.
Vidigal Fde, C., et al., Prevalence of metabolic syndrome and pre-metabolic syndrome in health professionals: LATINMETS Brazil study. Diabetol Metab Syndr, 2015. 7: p. 6.
Singh Balhara, Y.P., et al., Which Criteria to Use to Identify Metabolic Syndrome among Patients with Addictive Disorders?: Observations among Patients with Alcohol and Opioid Dependence Syndrome. Indian J Endocrinol Metab, 2018. 22(4): p. 565-568.
Vallecillo, G., et al., Metabolic syndrome among individuals with heroin use disorders on methadone therapy: Prevalence, characteristics, and related factors. Subst Abus, 2018. 39(1): p. 46-51.
Salarian, A., et al., Opioid use disorder induces oxidative stress and inflammation: the attenuating effect of methadone maintenance treatment. Iranian journal of psychiatry, 2018. 13(1): p. 46.
Chan, Y.Y., et al., Inflammatory response in heroin addicts undergoing methadone maintenance treatment. Psychiatry Res, 2015. 226(1): p. 230-4.
Rajagopalan, S., et al., Reactive oxygen species produced by macrophage-derived foam cells regulate the activity of vascular matrix metalloproteinases in vitro. Implications for atherosclerotic plaque stability. J Clin Invest, 1996. 98(11): p. 2572-9.
Schieber, M. and N.S. Chandel, ROS function in redox signaling and oxidative stress. Curr Biol, 2014. 24(10): p. R453-62.
Bakar, N.H.A., et al., Role of oxidative stress in opiate withdrawal and dependence: Exploring the potential use of honey. Journal of Applied Pharmaceutical Science, 2015. 5(12): p. 159-161.
Mannelli, P., et al., Opioid use affects antioxidant activity and purine metabolism: preliminary results. Hum Psychopharmacol, 2009. 24(8): p. 666-75.
Abdel-Zaher, A.O., et al., Role of oxidative stress and inducible nitric oxide synthase in morphine-induced tolerance and dependence in mice. Effect of alpha-lipoic acid. Behav Brain Res, 2013. 247: p. 17-26.
Ozmen, I., et al., Spinal morphine administration reduces the fatty acid contents in spinal cord and brain by increasing oxidative stress. Neurochem Res, 2007. 32(1): p. 19-25.
Pereska, Z., et al., Prooxidative/antioxidative homeostasis in heroin addiction and detoxification. Bratisl Lek Listy, 2007. 108(9): p. 393-8.
Ferreira, I.C., et al., Antioxidant activity of Portuguese honey samples: Different contributions of the entire honey and phenolic extract. Food Chemistry, 2009. 114(4): p. 1438-1443.
Pisprasert, V., et al., Limitations in the use of indices using glucose and insulin levels to predict insulin sensitivity: impact of race and gender and superiority of the indices derived from oral glucose tolerance test in African Americans. Diabetes Care, 2013. 36(4): p. 845-53.
Tatsch, E., et al., A simple and inexpensive automated technique for measurement of serum nitrite/nitrate. Clin Biochem, 2011. 44(4): p. 348-50.
Benzie, I.F. and J.J. Strain, The ferric reducing ability of plasma (FRAP) as a measure of "antioxidant power": the FRAP assay. Anal Biochem, 1996. 239(1): p. 70-6.
Beutler, E. and T. Gelbart, Plasma glutathione in health and in patients with malignant disease. J Lab Clin Med, 1985. 105(5): p. 581-4.
Janero, D.R., Malondialdehyde and thiobarbituric acid-reactivity as diagnostic indices of lipid peroxidation and peroxidative tissue injury. Free Radic Biol Med, 1990. 9(6): p. 515-40.
Cunha-Oliveira, T., A. Cristina Rego, and C. R Oliveira, Oxidative stress and drugs of abuse: an update. Mini-Reviews in Organic Chemistry, 2013. 10(4): p. 321-334.
Cunha-Oliveira, T., et al., Medical toxicology of drugs of abuse. Principles of Addiction-Comprehensive Addictive Behaviors and Disorders, 2013. 1: p. 159-175.
Cunha-Oliveira, T., A.C. Rego, and C.R. Oliveira, Cellular and molecular mechanisms involved in the neurotoxicity of opioid and psychostimulant drugs. Brain Res Rev, 2008. 58(1): p. 192-208.
Hurrle, S. and W.H. Hsu, The etiology of oxidative stress in insulin resistance. Biomed J, 2017. 40(5): p. 257-262.
Ceriello, A., et al., Impaired glucose metabolism in heroin and methadone users. Horm Metab Res, 1987. 19(9): p. 430-3.
Brambilla, F., et al., Glucose-insulin metabolism in herion addicts. Neuropsychobiology, 1976. 2(5-6): p. 341-9.
Cooper, O.B., T.T. Brown, and A.S. Dobs, Opiate drug use: a potential contributor to the endocrine and metabolic complications in human immunodeficiency virus disease. Clinical Infectious Diseases, 2003. 37(Supplement_2): p. S132-S136.
Passariello, N., et al., Glucose tolerance and hormonal responses in heroin addicts. A possible role for endogenous opiates in the pathogenesis of non-insulin-dependent diabetes. Metabolism, 1983. 32(12): p. 1163-5.
O'Sullivan, S.J., et al., Single-Cell Glia and Neuron Gene Expression in the Central Amygdala in Opioid Withdrawal Suggests Inflammation With Correlated Gut Dysbiosis. Front Neurosci, 2019. 13: p. 665.
Thomas Jefferson University. "The 'inflammation' of opioid use." ScienceDaily. ScienceDaily, 29 August 2019. www.sciencedaily.com/releases/2019/08/190829104621.htm. .
Dennis, B.B., et al., Evaluation of clinical and inflammatory profile in opioid addiction patients with comorbid pain: results from a multicenter investigation. Neuropsychiatr Dis Treat, 2014. 10: p. 2239-47.
Costello, E.J., et al., C-reactive protein and substance use disorders in adolescence and early adulthood: a prospective analysis. Drug Alcohol Depend, 2013. 133(2): p. 712-7.
Espinola-Klein, C., et al., Inflammatory markers and cardiovascular risk in the metabolic syndrome. Front Biosci (Landmark Ed), 2011. 16: p. 1663-74.
- Abstract Viewed: 436 times
- pdf Downloaded: 355 times