The Successful Treatment of High Lethal Dose Paraquat Poisoning With Hemoperfusion
International Journal of Medical Toxicology and Forensic Medicine,
Vol. 10 No. 3 (2020),
27 September 2020
Paraquat (PQ), as an herbicide, is mostly used by farmers, especially in the north-west of Iran. Easy access to PQ is the reason for PQ intoxication in farmers. However, poisoning with PQ is rare. Most of the PQ-poisoned patients ingest it deliberately and following a suicidal attempt. PQ poisoning treatment has a poor outcome; only a small dose of slightly more than 10 mL PQ could be harmful and damage lungs forever. Under the conditions of no specific clinical feature, proper history, and diagnostic test, diagnosis is usually difficult. The ingestion of PQ in toxic doses could be fatal, destroying the lungs, kidney, heart, gastrointestinal tract, liver, and other organs. To remove PQ from the blood and intoxicants, one of the best recommendations is Hemoperfusion (HP), as an extracorporeal method. In this case report, according to our treatments, early management of high lethal dose PQ poisoning, especially with HP could reduce the morbidity and mortality rates.
- Paraquat, Herbicide, Outcome, Hemoperfusion, Poisoning
How to Cite
Zaare Nahandi M, Banagozar Mohammadi A. Ban the Sale of Paraquat: General Health Promotion. Hakim Health Sys Res 2016; 19(2): 69- 71.
Saravu K, Sekhar S, Pai A, Barkur AS, Rajesh V, Earla JR. Paraquat – A deadly poison: Report of a case and review. Indian J Crit Care Med. 2013;17(3):182–184.
Kondle Raghu, Vidavalur Mahesh, Parri Sasidhar, Polam R. Reddy, Vajja Venkataramaniah, and Amit Agrawal. Paraquat Poisoning: A Case Report and Review of Literature. 2013; 20(3): 198–200.
Jagadeesan M. , Nithyananthan P. , Banupriya M. , Mahendrakumar K. , Prasanna Karthik S. , Kannan R. A study on clinical profile of paraquat poisoning in a tertiary care hospital. International Journal of Advances in Medicine. 2017; 4(4):1088-1091.
Li H, Song L, Jian X. Efficacy of hemoperfusion therapy in patients with paraquat poisoning: A meta-analysis. Inter¬national Journal of Clinical Experimental Medicine. 2017; 10(8):11371-81.
Ostadi A, Paeezi M. Hemoperfusion Efficiency in Paraquat Toxicity. International Journal of Medical Toxicology and Forensic Medicine. 2018; 8(4):151-156.
Yunying Shi., Yangjuan Bai., Yuangao Zou, Bei Cai, Fei Liu, Ping Fu, Lanlan Wang: The Value of Plasma Paraquat Concentration in Predicting Therapeutic Effects of Haemoperfusion in Patients with Acute Paraquat Poisoning. plosone.org 2012; 7(7): e40911
Wunnapuk K, Mohammed F, Gawarammana I, Liu X, Verbeeck RK, Buckley NA, Roberts MS, Musuamba FT: Prediction of paraquat exposure and toxicity in clinically ill poisoned patients: a model based approach. Br J Clin Pharmacol 2014; 78(4): 855–866.
Suntres ZE. Role of antioxidants in paraquat toxicity. Toxicology. 2002;180(1):65-77.
Li LR, Sydenham E, Chaudhary B, Beecher D, You C. Glucocorticoid with cyclophosphamide for paraquat-induced lung fibrosis. Cochrane Database of Systematic Reviews. 2014:CD008084. https://doi.org/10.1002/14651858.CD008084.pub4
Gawarammana, I., Buckley, N.A., Mohamed, F., Naser, K., Jeganathan, K., Ariyananada, P.L., Wunnapuk, K., Dobbins, T.A., Tomenson, J.A., Wilks, M.F. and Eddleston, M., 2018. High-dose immunosuppression to prevent death after paraquat self-poisoning–a randomised controlled trial. Clinical toxicology. 2018;56(7):633-639.
An Li, Wenxiong Li, Fengtong Hao, Haishi Wang : Early Stage Blood Purification for Paraquat Poisoning: A Multicenter Retrospective Study : Blood Purif 2016;42(2):93–99.
Liu, Xiao Wei, et al. Predictive values of urine paraquat concentration, dose of poison, arterial blood lactate and APACHE II score in the prognosis of patients with acute paraquat poisoning. Experimental and therapeutic medicine. 2017; 14(1): 79-86.
- Abstract Viewed: 168 times
- pdf Downloaded: 116 times