Colchicine Overdose in a Suicidal Attempt
International Journal of Medical Toxicology and Forensic Medicine,
Vol. 9 No. 4 (2019),
11 November 2019
,
Page 265-270
https://doi.org/10.32598/ijmtfm.v9i4.26520
Abstract
Colchicine overdose is uncommon; however, it can cause serious adverse effects and even death. Colchicine inhibits microtubule polymerization, causing mitotic spindle disruption. Ingesting ˃0.5 mg of colchicine per kilogram bodyweight causes severe adverse effects and can even be fatal. Therefore, colchicine toxicity must be accurately monitored and managed.
In this case report, we described a 21-year-old woman who attempted suicide by the ingestion of an estimated 30 mg colchicine. She was admitted to the hospital due to severe abdominal and chest pain, vomiting, lethargy, and weakness. The patient was medicated with ondansetron, apotel, antibiotics, platelet transfusions, sodium phosphate, calcium gluconate, calcitriol, desmopressin acetate, Granulocyte-Colony Stimulating Factor (G-CSF), and sodium bicarbonate. Fortunately, through the appropriate medical treatment, the signs and symptoms of colchicine toxicity were relieved and the patient survived despite the high colchicine serum level.
- Colchicine
- toxicity
- Case
How to Cite
References
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